- Gi-Wook Hwang (Laboratory of Molecular and Biochemical Toxicology, Graduate School of Pharmaceutical Sciences, Tohoku University / email@example.com)
1) Laboratory of Molecular and Biochemical Toxicology, Graduate School of Pharmaceutical Sciences, Tohoku University , 2) Laboratory of Pharmaceutical Health Sciences, School of Pharmacy, Aichi Gakuin University , 3) Department of Inhalation Toxicology Research, Korea Institute of Toxicology, Republic of Korea , 4) Department of Environmental Health, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences
We previously reported fluctuating levels of many metabolites in the brain of mice administered methylmercury. In this study, addition of putrescine, a polyamine, to the medium was found to confer methylmercury resistance to C17.2 mouse neural stem cells with regard to metabolites increased by methylmercury in the mouse brain. However, putrescine had little effect on the cytotoxicity of heavy metals such as cadmium and inorganic mercury. These results suggest that putrescine may selectively alleviate methylmercury toxicity.