Fundamental Toxicological Sciences

Paper Details

Fundamental Toxicological Sciences
Vol. 4 No. 1 February 17, 2017 p.15-21
Original Article
Normal ovarian aging, but modified T-cell differentiation, in female mice following neonatal exposure to bisphenol A
  • Ryo Ohta (Hatano Research Institute, Food and Drug Safety Center /
Ryo Ohta , Hideo Ohmukai , Tsukasa Negura , Yoshiyuki Tazura , Omoko Shindo
Hatano Research Institute, Food and Drug Safety Center
Keywords: Bisphenol A, Ovarian aging, Immunotoxicology, Mouse, Endocrine disruptor

In a previous study, we found that early life exposure to low-dose diethylstilbestrol accelerated onset of abnormal estrous cycles in female C57BL/6J mice. In order to observe the ovarian aging of mice exposed to substances on the candidate list for endocrine-disrupting properties, neonates of C57BL/6J mice were orally administered bisphenol A (BPA) at doses of 5 and 50 μg/kg/day. As a result, normal ovarian aging was observed in females treated with BPA. However, females treated with 5 and 50 μg/kg/day of BPA showed modified T-cell differentiation in the thymus. These results suggested that early life exposure to low-dose BPA did not induce premature ovarian failure but modified T-cell differentiation in female mice.