Paper Details
Fundamental Toxicological Sciences
Vol. 5
No. 2
April 18, 2018
p.71-73
Toxicomics Report
Putrescine selectively alleviates methylmercury toxicity in C17.2 mouse neural stem cells
- Gi-Wook Hwang (Laboratory of Molecular and Biochemical Toxicology, Graduate School of Pharmaceutical Sciences, Tohoku University / gwhwang@m.tohoku.ac.jp)
Masayuki Sato
1)
,
Jin-Yong Lee
1)
2)
,
Min-Seok Kim
1)
3)
,
Tsutomu Takahashi
1)
4)
,
Akira Naganuma
1)
,
Gi-Wook Hwang
1)
1) Laboratory of Molecular and Biochemical Toxicology, Graduate School of Pharmaceutical Sciences, Tohoku University , 2) Laboratory of Pharmaceutical Health Sciences, School of Pharmacy, Aichi Gakuin University , 3) Department of Inhalation Toxicology Research, Korea Institute of Toxicology, Republic of Korea , 4) Department of Environmental Health, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences
1) Laboratory of Molecular and Biochemical Toxicology, Graduate School of Pharmaceutical Sciences, Tohoku University , 2) Laboratory of Pharmaceutical Health Sciences, School of Pharmacy, Aichi Gakuin University , 3) Department of Inhalation Toxicology Research, Korea Institute of Toxicology, Republic of Korea , 4) Department of Environmental Health, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences
Keywords: Methylmercury, Toxicity, Putrescine
Abstracts
We previously reported fluctuating levels of many metabolites in the brain of mice administered methylmercury. In this study, addition of putrescine, a polyamine, to the medium was found to confer methylmercury resistance to C17.2 mouse neural stem cells with regard to metabolites increased by methylmercury in the mouse brain. However, putrescine had little effect on the cytotoxicity of heavy metals such as cadmium and inorganic mercury. These results suggest that putrescine may selectively alleviate methylmercury toxicity.