Fundamental Toxicological Sciences

Paper Details

Back
Fundamental Toxicological Sciences
Vol. 1 No. 3 November 10, 2014 p.113-114
Toxicomics Report
Identification of growth-dependent genes involved in paraquat toxicity in Saccharomyces cerevisiae
  • Akira Naganuma (Laboratory of Molecular and Biochemical Toxicology, Graduate School of Pharmaceutical Sciences, Tohoku University / naganuma@m.tohoku.ac.jp)
Tsutomu Takahashi 1) , JunXuan Zhu 1) , Naoya Sonoda 1) , Shusuke Kuge 1) 2) , Gi-Wook Hwang 1) , Akira Naganuma 1)
1) Laboratory of Molecular and Biochemical Toxicology, Graduate School of Pharmaceutical Sciences, Tohoku University , 2) Department of Microbiology, Tohoku Pharmaceutical University
Keywords: Paraquat, Resistance, Yeast, UTP4, UTP25
Full Text PDF[379K]
Abstracts

Using the yeast strain library we established by overexpressing each gene essential for yeast growth, we comprehensively searched for genes affecting the sensitivity of yeast to paraquat. As a result, seven novel genes, UTP4, UTP25, SEC65, NDD1, TFB2, TIM23, and CCT6, were identified as conferring paraquat resistance in yeast via overexpression.

Full Text PDF[379K]
Back
(C) 2014 Fundamental Toxicological Sciences.