Fundamental Toxicological Sciences

Paper Details

Fundamental Toxicological Sciences
Vol. 6 No. 7 October 11, 2019 p.253-258
Letter
Impact of dietary calcium and phosphorus levels on an ovariectomized Sprague-Dawley rat model of osteoporosis
  • Atsushi Watanabe (Department of Food and Nutritional Science, Graduate School of Agriculture, Tokyo University of Agriculture / watanabe.ab@om.asahi-kasei.co.jp)
  • Dai Nakae (Department of Food and Nutritional Science, Graduate School of Agriculture, Tokyo University of Agriculture / Department of Nutritional Science and Food Safety, Faculty of Applied Biosciences and Graduate School of Agriculture, Tokyo University of Agriculture / agalennde.dai@nifty.com)
Atsushi Watanabe 1) , Katsuhiro Miyajima 1) 2) , Noriko Kemuriyama 2) , Hisashi Uchiyama 3) , Takayuki Anzai 4) , Hijiri Iwata 5) , Reo Anzai 6) , Dai Nakae 1) 2)
1) Department of Food and Nutritional Science, Graduate School of Agriculture, Tokyo University of Agriculture , 2) Department of Nutritional Science and Food Safety, Faculty of Applied Biosciences and Graduate School of Agriculture, Tokyo University of Agriculture , 3) Japan SLC, Inc. , 4) Showa University School of Medicine , 5) Luna Path LLC Laboratory of Toxicologic Pathology , 6) Faculty of Environment and Information Studies, Keio University
Keywords: Osteoporosis, Calcium, Sprague-Dawley Rat, Bone biomarker, Parathyroid hormone, Postmenopausal
Abstracts

Ovariectomized rats were used as an animal model of osteoporosis in this study. They were given ad libitum access to a diet with high or low calcium to phosphorus ratio, or a normal diet, for a period of 10 weeks and effects on osteoporosis were assessed. Our results showed that the experimental diets affect urine levels of calcium and phosphorus, but do not affect the levels of biochemical, histopathological, or bone-related biomarkers. These results indicate that the administration of feed with different ratios of calcium to phosphorus (the phosphorus content was kept constant and the calcium content varied from 0.2× to 5× relative to the phosphorus content) over a period of 10 weeks does not accelerate the development of osteoporosis in ovariectomized rats with normal renal function to maintain homeostasis.