Paper Details
Fundamental Toxicological Sciences
Vol. 3
No. 2
March 04, 2016
p.63-65
Toxicomics Report
Transcription factor activation in rat primary astrocytes exposed to methylmercury
- Yasuhiro Ishihara (Laboratory of Molecular Brain Science, Graduate School of Integrated Arts and Sciences, Hiroshima University / ishiyasu@hiroshima-u.ac.jp)
Takuya Takemoto
1)
,
Yasuhiro Ishihara
1)
,
Mayumi Tsuji
2)
,
Toshihiro Kawamoto
2)
,
Takeshi Yamazaki
1)
1) Laboratory of Molecular Brain Science, Graduate School of Integrated Arts and Sciences, Hiroshima University , 2) Department of Environmental Health, University of Occupational and Environmental Health
1) Laboratory of Molecular Brain Science, Graduate School of Integrated Arts and Sciences, Hiroshima University , 2) Department of Environmental Health, University of Occupational and Environmental Health
Keywords: Methylmercury, Astrocytes, Transcription factor network
Abstracts
To investigate the adaptive response of astrocytes to an environmental chemical, methylmercury (MeHg), we herein examined transcription factors activated in rat primary astrocytes treated with 10 μM MeHg for 6 hr using the Combo Protein/DNA Array. The activities of 38 transcription factors increased by 5-fold or greater in response to MeHg. The paired box family of transcription factors were strongly activated by MeHg exposure, which are considered to be activated downstream of NGF and BDNF upregulation induced by MeHg. Nrf-2 (an antioxidant response element) was also activated, which has been reported to act on MeHg detoxification.