Fundamental Toxicological Sciences

Paper Details

Fundamental Toxicological Sciences
Vol. 3 No. 3 May 11, 2016 p.127-135
Acute hepatotoxicity induced by quetiapine fumarate in larval zebrafish
  • Li Zhou (Institute of Orthopaedics and Traumatology, Zhejiang Chinese Medical University, China /
Jinfeng Liang 1) , Wangdong Jin 2) , Haibin Wei 3) , Hongwen Li 4) , Fei Jia 1) , Jing Qian 1) , Hongcui Liu 5) , Yanfeng Huang 6) , Chunqi Li 5) 6) , Li Zhou 2) , Thomas Efferth 7)
1) Zhejiang Center for Drugs and Cosmetics Evaluation, Zhejiang Province Food and Drug Administration, China , 2) Institute of Orthopaedics and Traumatology, Zhejiang Chinese Medical University, China , 3) The Biospecimen Repository, Zhejiang Cancer Hospital, China , 4) Zhejiang Pharmaceutical College, China , 5) Hunter Biotechnology, Inc., China , 6) Wenzhou Medical University, China , 7) Department of Pharmaceutical Biology, Institute of Pharmacy and Biochemistry, Johannes Gutenberg University, Germany
Keywords: Quetiapine fumarate, Larval zebrafish, Hepatotoxicity, Liver, Yolk sac

Quetiapine fumarate (QF) is a widely used antipsychotic agent for the first-line treatment of schizophrenia, with good tolerability and compliance in humans and no observed adverse effects against liver. Taking advantages of zebrafish, which can be utilized in rapid drug screening and acute toxicity assessment, our study determined a certain hepatotoxicity of QF for the first time, indicating a potential safety hazard of this commonly used drug to humans.