Ryuma MATSUMOTO, Ryuichi AJISAKA, Yasuro SUGISHITA, Mitsuo MATSUDA, Keiji IIDA, Kaname IIDA, Takanori FUJITA, Iwao ITO

Cardiovascular Division, Department of Internal Medicine, Institute of Clinical Medicine, University of Tsukuba

キーワード : Dilated cardiomyopathy, Isometric exercise, Diastolic function, Nifedipine

　Seventeen patients with dilated cardiomyopathy (DCM) and 11 normal subjects were studied by digitized M-mode echocardiography during isometric exercise to assess the effect of nifedipine on left ventricular systolic and diastolic functions. Following sublingual nifedipine (10 mg), blood pressure and left ventricular end-systolic dimension (Ds) were decreased in patients with DCM. Although peak-dD/dt/D did not change, peak+dD/dt/D, one of the left ventricular filling indices, improved during exercise after nifedipine. In conclusion, sublingual nifedipine showed a favorable effect on diastolic function but not on systolic function during isometric exercise in patients with DCM.