Fundamental Toxicological Sciences

Paper Details

Fundamental Toxicological Sciences
Vol. 1 No. 3 November 10, 2014 p.109-111
Toxicomics Report
Overexpression of RPN8, SKP1, MIA40 or MES1 increases resistance to cadmium in Saccharomyces cerevisiae
  • Akira Naganuma (Laboratory of Molecular and Biochemical Toxicology, Graduate School of Pharmaceutical Sciences, Tohoku University / naganuma@m.tohoku.ac.jp)
Tsutomu Takahashi 1) , JunXuan Zhu 1) , Shusuke Kuge 1) 2) , Gi-Wook Hwang 1) , Akira Naganuma 1)
1) Laboratory of Molecular and Biochemical Toxicology, Graduate School of Pharmaceutical Sciences, Tohoku University , 2) Department of Microbiology, Tohoku Pharmaceutical University
Keywords: Cadmium, Yeast, RPN8, SKP1, MIA40, MES1
Abstracts

We screened for genes associated with cadmium resistance among genes essential for cell growth in yeast. Four novel genes, RPN8, SKP1, MIA40 and MES1, were identified as genes providing cadmium resistance to yeast via overexpression.