Fundamental Toxicological Sciences

Paper Details

Fundamental Toxicological Sciences
Vol. 2 No. 1 January 16, 2015 p.37-39
Letter
Effects of prenatal exposure to low doses of diethylstilbestrol on motor activity in newborn mice
  • Tetsuji Nagao (Laboratory of Developmental Biology, Department of Life Science, Kinki University / tnagao@life.kindai.ac.jp)
Kaho Ozaki 1) , Nao Kagawa 1) , Munekazu Komada 2) , Tetsuji Nagao 1)
1) Laboratory of Developmental Biology, Department of Life Science, Kinki University , 2) Department of Anatomy, Aichi Gakuin University
Keywords: Diethylstilbestrol, Motor activity, Neurobehavior, Newborn mouse
Abstracts

We developed a newborn mouse behavioral testing method to evaluate the risk of neurotoxicity of environmental toxicants, based on determining a newborn’s motor activity by applying the tare function of an analytical balance. Motor activities of newborn ICR mice exposed prenatally to diethylstilbestrol (DES) at 0.005-0.5 μg/kg/day on days 5 through 18 of gestation were evaluated on postnatal day 1. The activities of male newborns in the 0.05 μg/kg/day group were significantly increased compared to those of the controls, and the increasing tendencies were observed in both sexes of the highest group. The findings indicate that prenatal exposure to low doses of DES causes hyperactivity in newborn mice.