Fundamental Toxicological Sciences

Paper Details

Fundamental Toxicological Sciences
Vol. 3 No. 1 January 13, 2016 p.9-12
Single dose oral toxicity study of Picrorhiza kurroa rhizome extract in Wistar rats
  • Niti Sharma (Patanjali Natural Coloroma Pvt Ltd, India /
Acharya Bal Krishna 1) 2) , Hemanth Kumar Manikyam 2) , Vinay K Sharma 2) , Niti Sharma 2)
1) University of Patanjali, India , 2) Patanjali Natural Coloroma Pvt Ltd, India
Keywords: Picrorhiza kurroa, Hydroalcoholic extract, Wistar rats

Picrorhiza kurroa is a well-known ayurvedic or herbal medicine which is used very commonly in the treatment of various diseases. Therefore, we studied the oral toxicity of Picrorhiza kurroa rhizome extract in rats. A single high dose of the extract at 2000 mg/kg body weight was tested on Wistar rats. Mortality/viability and clinical signs were recorded on test day 0 (prior to administration), 7, 14 and at death. All animals appeared normal from day one to throughout the experimental procedure. Picrorhiza kurroa rhizome extract is non-toxic to rats and helped in weight gain with LD50 > 2000 mg/kg body weight. Oral administration of Picrorhiza kurroa is not connected with any toxicologically significant effects and the data could provide satisfactory preclinical evidence of safety to launch a clinical trial on a standardized formulation of the plant extracts.