- Akira Naganuma (Laboratory of Molecular and Biochemical Toxicology, Graduate School of Pharmaceutical Sciences, Tohoku University / email@example.com)
1) Laboratory of Molecular and Biochemical Toxicology, Graduate School of Pharmaceutical Sciences, Tohoku University , 2) Department of Inhalation Toxicology Research, Korea Institute of Toxicology , 3) Department of Environmental Health, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences , 4) Laboratory of Pharmaceutical Health Sciences, School of Pharmacy, Aichi Gakuin University , 5) Division of Health Effects Research, Japan National Institute of Occupational Safety and Health , 6) Department of Medical Neurobiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
Methylmercury is a harmful heavy metal that selectively disrupts the central nervous system. To clarify the transcription induction mechanism that operates in the brain in response to methylmercury exposure, we used a protein/DNA binding assay to identify transcription factors activated in the cerebella of mice administered methylmercury. We identified PAX4, PAX6, TCF3 and HMGA1 as transcription factors activated by methylmercury.