Paper Details
Fundamental Toxicological Sciences
Vol. 1
No. 3
November 10, 2014
p.113-114
Toxicomics Report
Identification of growth-dependent genes involved in paraquat toxicity in Saccharomyces cerevisiae
- Akira Naganuma (Laboratory of Molecular and Biochemical Toxicology, Graduate School of Pharmaceutical Sciences, Tohoku University / naganuma@m.tohoku.ac.jp)
Tsutomu Takahashi
1)
,
JunXuan Zhu
1)
,
Naoya Sonoda
1)
,
Shusuke Kuge
1)
2)
,
Gi-Wook Hwang
1)
,
Akira Naganuma
1)
1) Laboratory of Molecular and Biochemical Toxicology, Graduate School of Pharmaceutical Sciences, Tohoku University , 2) Department of Microbiology, Tohoku Pharmaceutical University
1) Laboratory of Molecular and Biochemical Toxicology, Graduate School of Pharmaceutical Sciences, Tohoku University , 2) Department of Microbiology, Tohoku Pharmaceutical University
Keywords: Paraquat, Resistance, Yeast, UTP4, UTP25
Abstracts
Using the yeast strain library we established by overexpressing each gene essential for yeast growth, we comprehensively searched for genes affecting the sensitivity of yeast to paraquat. As a result, seven novel genes, UTP4, UTP25, SEC65, NDD1, TFB2, TIM23, and CCT6, were identified as conferring paraquat resistance in yeast via overexpression.