Fundamental Toxicological Sciences

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2023 - Vol. 10

Original Article
Differential expression of Cytochrome P450 1A2 in simple fatty liver and steatohepatitis Vol.10, No.6, p.265-277
Azusa Kawashima , Naoto Uramaru , Toshiyasu Mikuma , Makoto Osabe , Toshiyuki Higuchi
Released: November 22, 2023
Abstract Full Text PDF[2M]
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Original Article
Titanium dioxide and silica nanoparticles inhibit the efflux of adriamycin in multi-drug resistant L1210/ADM cells Vol.10, No.6, p.259-264
Daisaku Miura , Teppei Koreeda , Naohiko Anzai , Ken-ichi Kiyomiya
Released: October 26, 2023
Abstract Full Text PDF[1M]
Supplemental Data
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Letter
Survey of toxicity study packages and designs of intravitreal drugs approved in Japan Vol.10, No.6, p.249-258
Kotaro Yamada , Yoshinori Yamagiwa , Yu Haranosono
Released: October 26, 2023
Abstract Full Text PDF[747K]
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Letter
Effects of expression of the 10-formyltetrahydrofolate metabolizing enzyme ALDH1L1 on pyrimidine nucleotide synthesis and the salvage pathway Vol.10, No.6, p.241-247
Masato Sasaki , Fumie Itoh , Nobuyuki Shibata
Released: October 26, 2023
Abstract Full Text PDF[4M]
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Original Article
Coffee diterpenes, cafestol and kahweol, display cytotoxicity and all-trans retinoic acid-induced superoxide generating activity-enhancing ability in U937 cells Vol.10, No.6, p.233-240
Hidehiko Kikuchi , Kaori Harata , Sumiko Akiyoshi , Takefumi Sagara , Harishkumar Madhyastha , Hitomi Mimuro , Futoshi Kuribayashi
Released: October 26, 2023
Abstract Full Text PDF[1M]
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Original Article
Effect of Anakinra (Kineret®) treatment on acrylamide-induced neurotoxicity in mice Vol.10, No.5, p.221-231
Alzahraa Fergany , Frederick Adams Ekuban , Cai Zong , Gaku Ichihara
Released: October 06, 2023
Abstract Full Text PDF[2M]
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Original Article
Subchronic oral toxicity study of Monascus Color in beagle dogs Vol.10, No.5, p.209-219
Akihiro Hagiwara , Yunagi Murase , Shuuhei Kubo , Haruko Koizumi , Mikio Nakamura , Shoji Fukushima
Released: September 25, 2023
Abstract Full Text PDF[836K]
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Original Article
Investigation of the maximum feasible volume of subretinal injections into rat and cynomolgus monkey eyes Vol.10, No.5, p.199-208
Megumi Sakata , Tomoaki Araki , Masayuki Tomohiro
Released: August 10, 2023
Abstract Full Text PDF[3M]
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Original Article
An application of the magnetometer detection system to Crl:CD1 (ICR) mice for head twitch response induced by hallucinogenic 5-HT2A agonists Vol.10, No.5, p.189-197
Mari Nakamura , Motoki Hojo , Ayaka Kawai , Kiyomi Ikushima , Akemichi Nagasawa , Hideyo Takahashi , Kosho Makino , Toshinari Suzuki , Jin Suzuki , Akiko Inomata
Released: August 10, 2023
Abstract Full Text PDF[4M]
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Letter
Effect of blood collection tubes containing separation gels on the measurement of drug concentrations in clinical toxicology Vol.10, No.5, p.179-187
Mayuu Tokudome , Asuka Kaizaki-Mitsumoto , Satoshi Numazawa
Released: August 04, 2023
Abstract Full Text PDF[1M]
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Original Article
Toxicological effects of repeated subcutaneous administration of corn oil for 4 weeks in rats Vol.10, No.4, p.169-178
Takayasu Moroki , Fumika Akizawa , Satoshi Kondo , Sakura Fujiwara , Tsuyoshi Yoshikawa , Yuki Inoue
Released: July 11, 2023
Abstract Full Text PDF[2M]
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Original Article
Evaluation of maximal dosing volume for intravitreal injections in cynomolgus monkeys Vol.10, No.4, p.157-167
Megumi Sakata , Tomoaki Araki , Masayuki Tomohiro
Released: July 04, 2023
Abstract Full Text PDF[4M]
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Data Report
Safety studies of LAURESH® a standardized Laurus nobilis leaf extract Vol.10, No.4, p.143-156
Chin Piow Wong , Yukiko Kobayashi , Jinwei Yang
Released: June 23, 2023
Abstract Full Text PDF[3M]
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Original Article
mRNA expression levels of CCL4, IL6, and CXCL2 in multiwalled carbon nanotube induced lung tumors in rats Vol.10, No.4, p.137-141
Nahida Sultana , Katsumi Fukamachi , Dipankar Chandra Roy , Jiegou Xu , Hiroyuki Tsuda , Masumi Suzui
Released: June 14, 2023
Abstract Full Text PDF[2M]
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Toxicomics Report
Effect of cadmium on expression of BIRC family genes in HeLa cells Vol.10, No.3, p.133-136
Jin-Yong Lee , Maki Tokumoto , Gi-Wook Hwang , Masahiko Satoh
Released: May 30, 2023
Abstract Full Text PDF[1M]
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Letter
K16ApoE inhibits the activity of acetylcholinesterase but is not the primary toxicological mechanism in mice Vol.10, No.3, p.125-131
Linlin Shao , Toby M. Michelena
Released: May 30, 2023
Abstract Full Text PDF[1M]
Supplemental Data
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Original Article
A trial to predict skin irritancy of cosmetic products using cytotoxicity tests Vol.10, No.3, p.113-123
Minori Mezaki , Chika Manabe , Junichiro Nagumo , Tomohisa Yoshimura , Tohru Nagahama , Hiroshi Itagaki , Akiko Takaoka
Released: May 12, 2023
Abstract Full Text PDF[1M]
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Minireview
A survey of on the use of genotoxicity and carcinogenicity testing packages for ophthalmic drug development Vol.10, No.3, p.105-112
Haruna Tahara , Yu Haranosono
Released: May 12, 2023
Abstract Full Text PDF[726K]
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Original Article
Derivation of human health hazard assessment values of 1,2-dichloroethane under the Japan Chemical Substances Control Law Vol.10, No.3, p.91-103
Akira Kawashima , Kaoru Inoue , Kazuo Ushida , Kaoru Kai , Hiroshi Suzuki , Lucia Satiko Yoshida-Yamashita , Akihiko Hirose , Kenichi Masumura
Released: April 14, 2023
Abstract Full Text PDF[706K]
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Retraction
Retraction: Quantitative morphometric analysis of vimentin filaments in Sertoli cells of rats after in utero DBP exposure
[Notice] The Original Article was published on May 13, 2017		 Vol.10, No.3, p.1-1
Eisuke Kume , Yuya Okayama , Mituru Sugiyama , Hiroyuki Takahashi , Tomoko Muto , Michael F. Wempe , Hiroshi Ikegami , Shin Wakui
Released: June 06, 2023
Abstract Full Text PDF[588K]
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Original Article
Effects of continuous thiamine intake on onset and progression of type 2 diabetes in leptin-receptor deficient mice Vol.10, No.2, p.83-90
Yuka Kohda
Released: March 27, 2023
Abstract Full Text PDF[2M]
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Data Report
A 90-day repeated oral dose toxicity study of 2-Butylbenzo[d]isothiazol-3(2H)-one in rats Vol.10, No.2, p.69-82
Makiko Kuwagata , Masaru Tsuboi , Toshime Igarashi , Mariko Tsurumoto , Takuya Nishimura , Yuhji Taquahashi , Satoshi Kitajima
Released: March 02, 2023
Abstract Full Text PDF[2M]
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Data Report
A 90-day dose toxicity study of 2-(2H-benzotriazol-2-yl)-6-dodecyl-4-methylphenol in rats Vol.10, No.2, p.59-68
Makiko Kuwagata , Masaru Tsuboi , Toshime Igarashi , Mariko Tsurumoto , Takuya Nishimura , Yuhji Taquahashi , Satoshi Kitajima
Released: March 02, 2023
Abstract Full Text PDF[1M]
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Original Article
Chlorella modulation of gut microbiota dysbiosis in patients with type-2 diabetes Vol.10, No.2, p.45-58
Fernanda Martins , Tamara C. Lopes de Castro , Andrey Santos , Dioze Guadagnini , Rose C. G. Trevisane , Ricardo P. Moreira , Edite Taninaga , Mario J. A. Saad , Mary L. S. Queiroz , Cristiane Okuda Torello
Released: February 24, 2023
Abstract Full Text PDF[2M]
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Original Article
Chlorella improves inflammatory profiles and quality of life of prediabetes and diabetes patients Vol.10, No.2, p.31-44
Fernanda Martins , Tamara C. Lopes de Castro , Sara T. Olalla Saad , Rose C. G. Trevisane , Ricardo P. Moreira , Edite Taninaga , Mary L. S. Queiroz , Cristiane Okuda Torello
Released: February 24, 2023
Abstract Full Text PDF[1M]
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Letter
mRNA expression profile of cytokines in rat primary alveolar macrophages treated with multiwalled carbon nanotube (MWCNT) Vol.10, No.1, p.27-30
Nahida Sultana , Katsumi Fukamachi , Jiegou Xu , Hiroyuki Tsuda , Masumi Suzui
Released: February 17, 2023
Abstract Full Text PDF[698K]
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Letter
DNA damage mediated by 4,4'-methylenebis(2-chloroaniline) cannot be detected via the DNA damage marker γH2AX: A case study Vol.10, No.1, p.21-25
Saho Kobayashi , Hiroki Kashiwagi
Released: February 15, 2023
Abstract Full Text PDF[1M]
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Original Article
Paternal exposure to methylphenidate induces ADHD-like behavioral phenotypes and altered gene expressions in mouse offspring Vol.10, No.1, p.7-20
Ryota Nakano , Asuka Kaizaki-Mitsumoto , Satoshi Numazawa
Released: February 01, 2023
Abstract Full Text PDF[2M]
Supplemental Data
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Toxicomics Report
PPAR gamma negatively regulates the expression of TRPM8 in normal epidermal cells but mutually regulate their expressions with TRPM8 by feed-back loop regulation in squamous carcinoma cells Vol.10, No.1, p.1-6
Tomofumi Fujino , Mizuki Nakamura , Saki Ohkawa
Released: January 13, 2023
Abstract Full Text PDF[1M]
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2022 - Vol. 9

Original Article
An in vitro microfluidic culture device for peripheral neurotoxicity prediction at low concentrations based on deep learning Vol.9, No.7, p.203-209
Xiaobo Han , Naoki Matsuda , Kazuki Matsuda , Makoto Yamanaka , Ikuro Suzuki
Released: December 23, 2022
Abstract Full Text PDF[3M]
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Letter
Transient increase in plasma urate induced by a single oral dose of fructose in rats Vol.9, No.7, p.197-202
Wataru Yoshioka , Mayuko Nagamura , Ryosuke Tanino , Akinari Shimada , Kimiyoshi Ichida
Released: December 02, 2022
Abstract Full Text PDF[747K]
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Original Article
Pharmaceutical concentrations and antimicrobial activity using hypersusceptible Escherichia coli lacking TolC component of multidrug efflux system in the Ayase River in Japan Vol.9, No.6, p.187-196
Tsuyoshi Murahashi , Jun-ichi Yamagishi , Kunihiko Nishino , Reika Takada , Takumi Sekine , Yoshikazu Matsuda , Toshiyuki Higuchi
Released: November 30, 2022
Abstract Full Text PDF[1M]
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Original Article
Role of cytoplasmic acetyltransferases, NAA60 and HAT1, in cellular protection against genotoxic agents Vol.9, No.6, p.179-186
Pasjan Satrimafitrah , Hideki Nishitoh , Yasunari Takami
Released: November 09, 2022
Abstract Full Text PDF[3M]
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Letter
Assessment of genotoxicity of 2-[2-(acetylamino)-4-[bis(2-hydroxyethyl)amino]-5-methoxyphenyl]-5-amino-7-bromo-4-chloro-2H-benzotriazole (PBTA-6) in zebrafish (Danio rerio) using the comet assay and micronucleus test Vol.9, No.6, p.173-178
Yuya Deguchi , Tomoyasu Toyoizumi , Hiroaki Nagaoka , Shuichi Masuda
Released: November 09, 2022
Abstract Full Text PDF[1M]
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Letter
Induction of CYP3A4 mRNA by cooked food-derived carcinogenic heterocyclic aromatic amines in human HPL-A3 cells Vol.9, No.6, p.167-172
Masashi Sekimoto , Natsuki Yamashita , Seiichiro Maeda , Masakuni Degawa
Released: October 28, 2022
Abstract Full Text PDF[1021K]
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Data Report
Comet assay of thyroid gland in rats treated with ethyl methanesulfonate Vol.9, No.5, p.163-166
Naho Tsuji , Soichiro Hagio , Kazuya Takeuchi , Satoshi Furukawa
Released: October 12, 2022
Abstract Full Text PDF[700K]
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Toxicomics Report
Deubiquitinase USP54 attenuates methylmercury toxicity in human embryonic kidney 293 cells Vol.9, No.5, p.159-162
Jin-Yong Lee , Jong-Mu Kim , Takuya Noguchi , Atsushi Matsuzawa , Akira Naganuma , Gi-Wook Hwang
Released: October 07, 2022
Abstract Full Text PDF[885K]
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Original Article
Bifunctional activity of tangeretin (5,6,7,8,4'-pentamethoxyflavone) in suppression of cell growth and gene expression of the superoxide-generating system-related proteins in U937 cells Vol.9, No.5, p.151-157
Hidehiko Kikuchi , Kaori Harata , Sumiko Akiyoshi , Takefumi Sagara , Harishkumar Madhyastha , Hitomi Mimuro , Futoshi Kuribayashi
Released: October 07, 2022
Abstract Full Text PDF[949K]
Supplemental Data
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Original Article
The effects on growth and reproductive function by parabens in C. elegans Vol.9, No.5, p.145-150
Yuko Sakaguchi , Nana Hirota , Satoshi Fukushima , Nobuhiro Ichikawa , Koji Arizono
Released: September 13, 2022
Abstract Full Text PDF[1M]
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Original Article
Cryopreserved human hepatocytes culture optimization on polymethylpentene oxygen permeable membranes for drug screening purposes Vol.9, No.4, p.135-144
Mathieu Anoy , Benedikt Scheidecker , Hiroshi Arakawa , Katsuhiro Esashika , Naoki Ishida , Hiroyasu Ito , Hisaaki Yanai , Jun Takahashi , Masaki Nishikawa , Yukio Kato , Yasuyuki Sakai
Released: September 07, 2022
Abstract Full Text PDF[2M]
Supplemental Data
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Original Article
Derivation of human health hazard assessment values for toluene under the Japanese Chemical Substances Control Law Vol.9, No.4, p.123-133
Akira Kawashima , Kaoru Inoue , Kazuo Ushida , Kaoru Kai , Hiroshi Suzuki , Mariko Matsumoto , Kenichi Masumura , Akihiko Hirose
Released: September 07, 2022
Abstract Full Text PDF[985K]
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Letter
Leaf extracts from Camellia sinensis and Argania spinosa suppress oxidative stress and chemokine release in human 3-dimensional cultured epidermis exposed to PM2.5 collected with cyclonic separation Vol.9, No.4, p.117-122
Maori Kono , Tomoaki Okuda , Masayuki Takaishi , Hidefumi Ikeda , Nami Ishihara , Yasuhiro Ishihara
Released: September 07, 2022
Abstract Full Text PDF[959K]
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Letter
De novo transgenerational inheritance of male rat hyperactivity by rotenone Vol.9, No.4, p.111-115
Masami Ishido
Released: September 07, 2022
Abstract Full Text PDF[1M]
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Original Article
Fecal microRNA223 as an indicator of recovery in chronic DSS colitis model in rats Vol.9, No.3, p.103-110
Terutaka Kodama , Yuko Togashi , Naomi Matsutani , Seiichiro Kurashige , Toyohiko Aoki , Yasuteru Otagiri
Released: July 06, 2022
Abstract Full Text PDF[1M]
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Original Article
Multigenerational effects of neonicotinoids (acetamiprid, clothianidin) on growth, fertility and motility of nematode C. elegans Vol.9, No.3, p.95-102
Yuko Sakaguchi , Saki Mikami , Naoko Ikoma , Sadahiro Kawazoe , Masaya Uchida , Nobuaki Tominaga , Koji Arizono , Nobuhiro Ichikawa
Released: July 06, 2022
Abstract Full Text PDF[2M]
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Original Article
Occupational exposure of pharmacists to drugs during tablet crushing and its countermeasures Vol.9, No.3, p.85-93
Tsuyoshi Murahashi , Miho Arai , Kengo Ogata , Manami Matsumoto , Toshiyuki Higuchi
Released: May 24, 2022
Abstract Full Text PDF[1M]
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Original Article
Genotoxicity and subchronic toxicity of a kaempferol aglycone-rich product produced from horseradish leaves Vol.9, No.3, p.71-83
Hiroki Kimoto , Sakura Fujiwara , Noriyuki Koyama , Tohru Uesugi
Released: May 19, 2022
Abstract Full Text PDF[933K]
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Original Article
Potential human health risks of mercury-contaminated cassavas – Preliminary studies Vol.9, No.2, p.61-69
Sylvester Addai-Arhin , Randy Novirsa , Hui Ho Jeong , Quang Dinh Phan , Nana Hirota , Yasuhiro Ishibashi , Hideki Shiratsuchi , Koji Arizono
Released: April 27, 2022
Abstract Full Text PDF[1M]
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Letter
Relationship between micronucleus formation and oxidative stress in human vascular endothelial cells under low dose rate irradiation Vol.9, No.2, p.47-59
Qingmei Meng , Ikue Hayashi , Kumiko Anno , Junya Kobayashi
Released: April 05, 2022
Abstract Full Text PDF[2M]
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Letter
Molecular network analysis of RNA viral infection pathway in diffuse- and intestinal-type gastric cancer Vol.9, No.2, p.37-46
Shihori Tanabe , Sabina Quader , Ryuichi Ono , Horacio Cabral , Kazuhiko Aoyagi , Akihiko Hirose , Hiroshi Yokozaki , Hiroki Sasaki
Released: April 05, 2022
Abstract Full Text PDF[4M]
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Letter
Absence of in vivo mutagenicity of 4,4'-oxybis(benzenesulfonohydrazide) in liver and glandular stomach of MutaTM Mouse Vol.9, No.2, p.31-36
Takako Iso , Masakatsu Natsume , Yasumasa Murata , Yoshiyuki Shigeta , Nozomu Hirose , Takaaki Umano , Katsuyoshi Horibata , Kenichi Masumura , Kei-ichi Sugiyama , Mariko Matsumoto , Akihiko Hirose
Released: April 05, 2022
Abstract Full Text PDF[860K]
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Erratum
Erratum: Utility of murine dendritic cell line DC2.4 for in vitro assay of skin-sensitization potential Vol.9, No.1, p.25-30
Erina Shiraishi , Akiko Ido , Youhei Hiromori , Kento Tanaka , Tomoki Kimura , Hisamitsu Nagase , Tsuyoshi Nakanishi
Released: March 16, 2022
Abstract Full Text PDF[1M]
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Erratum
Erratum: Safety assessment of a soluble dietary fiber, isomaltodextrin, enzymatically produced from starch Vol.9, No.1, p.23-23
Tsuyoshi SadakiyoSadakiyo , Shin-ichiro Inoue , Yuki Ishida , Hikaru Watanabe , Hitoshi Mitsuzumi , Shimpei Ushio
Released: February 28, 2022
Abstract Full Text PDF[509K]
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Letter
A novel high-purity carbon-nanotube yarn electrode used to obtain biopotential measurements in small animals: flexible, wearable, less invasive, and gel-free operation Vol.9, No.1, p.17-21
Yuhji Taquahashi , Shuji Tsuruoka , Koichi Morita , Masaki Tsuji , Kousuke Suga , Ken-ich Aisaki , Satoshi Kitajima
Released: January 18, 2022
Abstract Full Text PDF[1M]
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Letter
Dietary rapeseed (canola) oil suppresses testosterone production and increases plasma aldosterone level in stroke-prone spontaneously hypertensive rats (SHRSP) Vol.9, No.1, p.7-16
Mai Nishikawa , Naoki Ohara , Yukiko Naito , Chihiro Amma , Yoshiaki Saito , Kenjiro Tatematsu , Jinhua Baoyindugurong , Daisuke Miyazawa , Yoko Hashimoto , Harumi Okuyama
Released: January 15, 2022
Abstract Full Text PDF[2M]
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Letter
Glyceraldehyde 3-phosphate dehydrogenase converts methylmercury to its sulfur adduct with lowered toxicity through sulfane sulfur atoms on Cys247 Vol.9, No.1, p.1-5
Yumi Abiko , Eiko Yoshida , Yoshito Kumagai
Released: January 15, 2022
Abstract Full Text PDF[2M]
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2021 - Vol. 8

Original Article
Low-dose ionizing radiation suppresses the apoptosis-induced by serum-removal culture Vol.8, No.7, p.249-260
Yuki Nakamura , Shinsuke Katoh , Junya Kobayashi , Tomonobu Umeda , Yoshiko Kobayashi , Satoshi Numazawa
Released: December 31, 2021
Abstract Full Text PDF[3M]
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Original Article
Intake of wheat bran after administration of methylmercury reduces mercury accumulation in mice Vol.8, No.7, p.243-248
Masaaki Nagano , Masatake Fujimura
Released: December 31, 2021
Abstract Full Text PDF[795K]
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Original Article
Focus on orexin-A in obese diabetes rats: upregulation of orexin-A receptor in the diabetic brain Vol.8, No.7, p.235-241
Yuka Kohda
Released: December 25, 2021
Abstract Full Text PDF[846K]
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Letter
Time-dependent changes in serum concentrations of acyclovir and its metabolite, 9-carboxymethoxymethylguanine, in a patient with suspected acyclovir encephalopathy Vol.8, No.7, p.229-233
Kazumasa Abe , Asuka Kaizaki-Mitsumoto , Tomohiro Saito , Motonori Sugiyama , Hirokazu Honda , Satoshi Numazawa
Released: December 22, 2021
Abstract Full Text PDF[888K]
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Letter
Influence of trans-fatty acids on non-alcoholic steatohepatitis with hepatic fibrosis induced by a choline-deficient, methionine-lowered, L-amino acid-defined diet in male Harlan Sprague Dawley rats Vol.8, No.7, p.221-228
Kinuko Uno , Katsuhiro Miyajima , Marika Matsumoto , Marika Toma , Noriko Suzuki-Kemuriyama , Dai Nakae
Released: December 10, 2021
Abstract Full Text PDF[5M]
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Letter
Effects of intranasal administration of multi-walled carbon nanotube (MWCNT) suspension on respiratory syncytial virus (RSV) infection in mice Vol.8, No.7, p.215-220
Seiko Hashiguchi , Aki Miyauchi , Keiji Komemoto , Tomoyuki Ueda , Kenji Tokuda , Akihiko Hirose , Hiroki Yoshida , Toshi Akashi , Masahiko Kurokawa , Wataru Watanabe
Released: November 25, 2021
Abstract Full Text PDF[2M]
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Letter
Potency shift in immunomodulatory activities of zinc oxide (ZnO) nanoparticles in THP-1 cells is associated with cytotoxicity Vol.8, No.7, p.205-213
Atsuko Miyajima , Tsuyoshi Kawakami , Kaoru Komoriya , Reiko Kato , Makoto Usami , Kazuo Isama
Released: November 25, 2021
Abstract Full Text PDF[3M]
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Original Article
Quantitative structure-activity relationship and a category approach to support algal toxicity assessment of human pharmaceuticals Vol.8, No.7, p.195-204
Takashi Yamada , Tomoko Kawamura , Taeko Maruyama , Masayuki Kurimoto , Hiroshi Yamamoto , Naruo Katsutani , Akihiko Hirose
Released: November 16, 2021
Abstract Full Text PDF[2M]
Supplemental Data
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Original Article
Electroporation of thalidomide to medaka (Oryzias latipes) embryo for evaluation of developmental toxicity Vol.8, No.6, p.189-193
Yuki Nishiyama , Masaya Uchida , Aki Terada , Susumu Kono , Hiroshi Ishibashi , Koji Arizono , Nobuaki Tominaga
Released: November 09, 2021
Abstract Full Text PDF[1M]
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Letter
Improvement of a fish holding device for oral administration to zebrafish Vol.8, No.6, p.183-187
Naomi Fujiwara , Shinichi Nonaka , Yukiko Yanoue , Masao Tomiki , Miki Nishi , Shiro Toyohisa , Osamu Saika
Released: November 09, 2021
Abstract Full Text PDF[859K]
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Original Article
Expression of miRNAs in the colon, rectum, plasma, and feces in rats with dextran sulfate sodium Vol.8, No.6, p.177-182
Terutaka Kodama , Yuko Togashi , Naomi Matsutani , Seiichiro Kurashige , Toyohiko Aoki , Yasuteru Otagiri
Released: November 05, 2021
Abstract Full Text PDF[1M]
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Original Article
Development of an inhalation exposure system of a pressurized metered-dose inhaler (pMDI) formulation for small experimental animals Vol.8, No.6, p.169-175
Yuhji Taquahashi , Hirokatsu Saito , Makiko Kuwagata , Satoshi Kitajima
Released: October 28, 2021
Abstract Full Text PDF[2M]
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Original Article
Diverse unintended on-target mutations induced by zygote genome-editing using CRISPR/Cas9 system Vol.8, No.5, p.161-167
Toshime Igarashi , Yukuto Yasuhiko , Ryuichi Ono , Erika Tachihara , Miki Uchiyama , Atsuya Takagi , Yu Takahashi , Makiko Kuwagata , Satoshi Kitajima
Released: October 28, 2021
Abstract Full Text PDF[2M]
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Toxicomics Report
Knockdown of deubiquitinating enzyme Usp34 confers resistance to methylmercury in HEK293 cells Vol.8, No.5, p.157-160
Jong-Mu Kim , Jin-Yong Lee , Min-Seok Kim , Sawako Shindo , Takeshi Kumagai , Akira Naganuma , Gi-Wook Hwang
Released: October 20, 2021
Abstract Full Text PDF[907K]
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Original Article
Relationship between renal dysfunction and change in serum electrolyte levels in patients administered with liposomal amphotericin B Vol.8, No.5, p.147-155
Kaito Yamashiro , Atsushi Hirata , Ryosuke Ota , Fumihiko Ogata , Takehiro Nakamura , Naohito Kawasaki
Released: October 20, 2021
Abstract Full Text PDF[873K]
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Original Article
Extract of Siraitia grosvenorii (Luo Han Guo) protects against hepatic fibrosis in mice on a choline-deficient, methionine-lowered, L-amino acid-defined, high-fat diet without trans fatty acids Vol.8, No.5, p.135-145
Noriko Suzuki-Kemuriyama , Akari Abe , Sae Nakane , Kinuko Uno , Shuji Ogawa , Atsushi Watanabe , Ryuhei Sano , Megumi Yuki , Katsuhiro Miyajima , Dai Nakae
Released: October 20, 2021
Abstract Full Text PDF[4M]
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Original Article
Safety evaluation of 2-aza-8-oxohypoxanthine by in vitro skin sensitization and human tests Vol.8, No.4, p.123-133
Hisae Aoshima , Takunori Matsumoto , Rinta Ibuki , Hirokazu Kawagishi
Released: September 10, 2021
Abstract Full Text PDF[1M]
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Original Article
Health risk assessment on mercury, cadmium and lead in marketed cigarettes Vol.8, No.4, p.117-122
Quang Phan Dinh , Sylvester Addai-Arhin , Randy Novirsa , Huiho Jeong1 , Willy Cahya Nugraha , Pham Hung Viet , Nobuaki Tominaga , Yasuhiro Ishibashi , Koji Arizono
Released: September 08, 2021
Abstract Full Text PDF[758K]
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Original Article
Repeated-dose and reproductive/developmental toxicity screening of polyoxymethylene in rats Vol.8, No.4, p.103-116
Mariko Matsumoto , Sakiko Fujii , Nozomu Hirose , Takako Iso , Yoshiyuki Shigeta , Yasumasa Murata , Kaoru Inoue , Akihiko Hirose
Released: August 27, 2021
Abstract Full Text PDF[902K]
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Letter
Antidiabetic agent did not impair spermatogenesis in spontaneously hyperglycemic and diabetic rats Vol.8, No.4, p.97-101
Taiki Kobayashi , Takasumi Shimomoto , Junichi Namekawa , Masanobu Kanou , Hirotsugu Kato , Seishiro Sakamoto , Takeshi Iijima , Hideharu Ochiai
Released: August 02, 2021
Abstract Full Text PDF[849K]
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Original Article
Inorganic polyphosphate modulates leukocyte accumulation and vascular endothelial cell permeability and ameliorates cecal ligation and puncture-induced lethality Vol.8, No.3, p.89-96
Yoshitaka Yamazaki , Mikako Terashima-Hasegawa , Atsufumi Manabe , Toshikazu Shiba , Yumi Kawazoe , Takashi Ashino , Masahiro Hosonuma , Satoshi Numazawa
Released: July 27, 2021
Abstract Full Text PDF[1004K]
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Data Report
Movento® 240SC (Spirotetramat) and Envidor® 240SC (Spirodiclofen) keto-enol insecticides induce DNA damage in Drosophila melanogaster ovaries Vol.8, No.3, p.81-88
Berenyce González-Marín , María Elena Calderón-Segura , Ana Karen González Pérez , Luis Gerardo Moreno Ciénega
Released: July 27, 2021
Abstract Full Text PDF[923K]
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Original Article
Effects of the ethanol extract of Neopyropia yezoensis, cultivated in the Seto Inland Sea (Setonaikai), on the viability of 10 human cancer cells including endocrine therapy-resistant breast cancer cells Vol.8, No.3, p.75-80
Shuso Takeda , Masayo Hirao-Suzuki , Yukimasa Yamagishi , Takahiro Sugihara , Masataka Kaneko , Genki Sakai , Tetsuya Nakamura , Yuhzo Hieda , Masufumi Takiguchi , Masahiro Okada , Narumi Sugihara
Released: June 23, 2021
Abstract Full Text PDF[1M]
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Letter
Evaluation of the in vitro cytotoxicity of oscillatoxins E and F under nutrient-starvation culture conditions Vol.8, No.3, p.69-73
Yusuke Hanaki , Yusuke Araki , Toshio Nishikawa , Ryo C. Yanagita
Released: June 15, 2021
Abstract Full Text PDF[1M]
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Original Article
Effects of hemoglobin on post-mortem oxidation of bromazepam Vol.8, No.2, p.61-67
Yoshikazu Yamagishi , Hirotaro Iwase , Yasumitsu Ogra
Released: May 27, 2021
Abstract Full Text PDF[1M]
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Original Article
3’, 4’-Dihydroxyflavone enhances all-trans retinoic acid-induced superoxide-generating activity through up-regulating transcription of gp91-phox in human monoblastic U937 cells, as opposed to flavone and other hydroxyflavone derivatives Vol.8, No.2, p.53-59
Hidehiko Kikuchi , Kaori Harata , Sumiko Akiyoshi , Harishkumar Madhyastha , Futoshi Kuribayashi
Released: May 27, 2021
Abstract Full Text PDF[1M]
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Data Report
Acrylamide in dog food Vol.8, No.2, p.49-52
Kazutoshi Sugita , Junpei Yamamoto , Kimika Kaneshima , Chika Kitaoka-Saito , Masashi Sekimoto , Osamu Endo , Yukihiko Takagi , Yuko Kato-Yoshinaga
Released: May 21, 2021
Abstract Full Text PDF[750K]
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Original Article
A 90-day oral repeated-dose toxicity study of Monascus Color Y-001 in rats Vol.8, No.2, p.37-47
Yuko Doi , Taiki Sugiyama , Akihiro Hagiwara , Norio Imai , Yukinori Mera , Toyohiko Aoki
Released: May 21, 2021
Abstract Full Text PDF[785K]
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Data Report
A survey on the cadmium contamination in brown rice sold in Tokyo Vol.8, No.2, p.33-36
Yukino Segawa , Setsuko Tabata , Izumi Hirayama , Kenji Iida , Ikuko Matsuno , Hisako Nakano , Takeo Sasamoto , Toshiyuki Kaji
Released: April 22, 2021
Abstract Full Text PDF[876K]
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Original Article
The influence of long-term ingestion of D-allulose in hypercholesterolemia patients under statin therapy Vol.8, No.1, p.23-31
Misuzu Tanaka , Akane Kanasaki , Noriko Hayashi , Tetsuo Iida , Koji Murao
Released: April 22, 2021
Abstract Full Text PDF[833K]
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Letter
Ouabagenin, an aglycone of cardiotonic steroid ouabain, functions as LXR ligand but avoids the increase in the SREBP-1 by inducing Krüppel-like factor 15 Vol.8, No.1, p.17-22
Tomofumi Fujino , Kouta Sugizaki , Saki Ohkawa , Sana Fujikawa , Toshiyuki Oshima , Makio Hayakawa
Released: March 27, 2021
Abstract Full Text PDF[1M]
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Original Article
Genotoxicity of Monascus Color Y-001 Vol.8, No.1, p.7-16
Ryosuke Sato , Michihito Takabe , Takahiro Ishii , Norio Imai , Yuko Doi , Toyohiko Aoki
Released: March 09, 2021
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Toxicomics Report
Comprehensive analysis of the alteration of plasma miRNA expression level in mice exposed to diesel exhaust Vol.8, No.1, p.1-6
Ken Tachibana , Iori Kodaira , Noriko Kuroiwa , Ryo Uzuki , Yusuke Shinkai , Ken Takeda
Released: February 12, 2021
Abstract Full Text PDF[768K]
Supplemental Data
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2020 - Vol. 7

Original Article
Age-related hepatic glucose-dependent insulinotropic polypeptide expression is modified by ongoing thiamine supplementation in obese diabetic rats Vol.7, No.6, p.291-299
Yuka Kohda
Released: December 24, 2020
Abstract Full Text PDF[1M]
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Letter
Inhibitory effects of L-NAME, a nitric oxide synthase inhibitor, on decidual cell proliferation in mid-to-late pregnant rats Vol.7, No.6, p.287-289
Wataru Ishikawa , Shugo Kazama , Takehito Suzuki , Rei Yamana , Yoko Miyazaki , Kazuaki Tanaka , Makoto Usami , Tatsuya Takizawa
Released: December 24, 2020
Abstract Full Text PDF[1M]
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Letter
Influence of skin condition on the skin penetration of dextran 4000 and ovalbumin Vol.7, No.6, p.281-286
Makiko Fujii , Miko Imai , Hiroki Kuwabara , Minori Awano , Kaname Hashizaki , Hiroyuki Taguchi
Released: November 25, 2020
Abstract Full Text PDF[2M]
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Original Article
Combined repeated-dose and reproductive/developmental oral toxicity of 3-methylpentane, isooctane, and isononane in rats Vol.7, No.6, p.259-279
Akira Kawashima , Kaoru Inoue , Yoshiro Yoshizaki , Kazuo Ushida , Kaoru Kai , Hiroshi Suzuki , Masao Takano , Sakiko Fujii , Kaoru Yabe , Mariko Matsumoto , Takashi Yamada , Akihiko Hirose
Released: October 23, 2020
Abstract Full Text PDF[1M]
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Letter
Electromagnetic fields (EMF) facilitate cell migration and BrdU incorporation during an EMF-sensitive phase in a rat neurosphere assay in vitro Vol.7, No.6, p.253-257
Masami Ishido , Eiko Shimaya
Released: October 21, 2020
Abstract Full Text PDF[1M]
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Letter
In vitro cytotoxicity of the thyrotoxic and hepatotoxic rubber antioxidant 2-mercaptobenzimidazole and its 4- or 5-methyl derivatives in rabbit corneal cells Vol.7, No.6, p.249-252
Yukie Kuroda , Atsuko Miyajima , Kazue Sakemi-Hoshikawa , Makoto Usami , Katsuyoshi Mitsunaga , Yasuo Ohno , Momoko Sunouchi
Released: August 26, 2020
Abstract Full Text PDF[1M]
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Original Article
Lack of combined effect of continuous exposure to α-glycosyl isoquercitrin from fetal stages to adulthood and voluntary exercise or environmental enrichment on learning and behaviors in rats Vol.7, No.5, p.241-248
Yasunori Masubuchi , Satomi Kikuchi , Hiromu Okano , Yasunori Takahashi , Kazumi Takashima , Ryota Ojiro , Qian Tang , Toshinori Yoshida , Mihoko Koyanagi , Robert R. Maronpot , Shim-mo Hayashi , Makoto Shibutani
Released: August 18, 2020
Abstract Full Text PDF[1M]
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Original Article
Nucleolin positively regulates spontaneous cell proliferation but is not involved in inhibition of proliferation by lead in cultured bovine aortic endothelial cells Vol.7, No.5, p.233-239
Tsutomu Takahashi , Yuka Takagi , Yuta Honma , Yo Shinoda , Yayoi Tsuneoka , Takato Hara , Chika Yamamoto , Toshiyuki Kaji , Yasuyuki Fujiwara
Released: August 03, 2020
Abstract Full Text PDF[2M]
Supplemental Data
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Original Article
Four-week repeated dose oral toxicity study of gum ghatti in rats Vol.7, No.5, p.227-232
Ryo Kawahara , Kenichiro Watanabe , Rina Yamane , Hideki Yasui , Nao Kikugawa , Naoko Mori , Ryosuke Akiyama , Takeshi Matsubara , Miwa Harada , Shinya Kaneda
Released: July 31, 2020
Abstract Full Text PDF[883K]
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Original Article
The dietary intake of mercury from rice and human health risk in artisanal small-scale gold mining area, Indonesia Vol.7, No.5, p.215-225
Randy Novirsa , Quang Phan Dinh , Huihoa Jeong , Sylvester Addai-Arhin , Willy Cahya Nugraha , Nana Hirota , Bambang Wispriyono , Yasuhiro Ishibashi , Koji Arizono
Released: July 07, 2020
Abstract Full Text PDF[1M]
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Original Article
Safety evaluation of 2-aza-8-oxohypoxanthine based on in vitro and human patch tests Vol.7, No.5, p.207-214
Hisae Aoshima , Sayuri Hyodo , Rinta Ibuki , Jing Wu , Jae-Hoon Choi , Hirokazu Kawagishi
Released: June 19, 2020
Abstract Full Text PDF[1M]
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Original Article
Retinoic acid dramatically enhances cytotoxicity of equol against human monoblastic U937 cells, but not against human peripheral neutrophils Vol.7, No.4, p.201-206
Hidehiko Kikuchi , Kaori Harata , Chikage Kawai , Harishkumar Madhyastha , Akira Yamauchi , Futoshi Kuribayashi
Released: May 27, 2020
Abstract Full Text PDF[1M]
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Original Article
Postnatal wheel running mitigates endocrine disruption of mammary gland development in mice Vol.7, No.4, p.189-199
Emily E. Schmitt , Weston W. Porter , J. Timothy Lightfoot
Released: May 27, 2020
Abstract Full Text PDF[4M]
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Letter
Repeated 28-day and 13-week dose toxicity studies of oils prepared from the internal organs of the Japanese giant scallop (Patinopecten yessoensis) in rats Vol.7, No.4, p.177-188
Koki Sugimoto , Eito Shimizu , Nozomi Hagihara , Ryota Hosomi , Kenji Fukunaga , Munehiro Yoshida , Takeya Yoshioka , Koretaro Takahashi
Released: May 27, 2020
Abstract Full Text PDF[959K]
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Original Article
The aminoethyl group is a crucial structural moiety in metal-mediated oxidative DNA damage by catecholamines Vol.7, No.4, p.171-176
Koji Ueda , Yoshihiko Nishino , Yoshinori Okamoto , Nakao Kojima , Hideto Jinno
Released: May 19, 2020
Abstract Full Text PDF[1M]
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Letter
Bacteriological evaluation of feasibility of food poisoning from long-term stored “pack-cooked” meals Vol.7, No.4, p.167-170
Toshihiro Kobayashi , Harumi Sakuda
Released: May 19, 2020
Abstract Full Text PDF[851K]
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Letter
Combined exposure to environmental electrophiles enhances cytotoxicity and consumption of persulfide Vol.7, No.3, p.161-166
Masahiro Akiyama , Takamitsu Unoki , Yoshito Kumagai
Released: May 09, 2020
Abstract Full Text PDF[3M]
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Original Article
Usefulness of HepaRG cells in the mitochondrial function assay for the estimation of potential risk of idiosyncratic drug-induced liver injury Vol.7, No.3, p.153-160
Keisuke Goda , Taku Masuyama
Released: May 09, 2020
Abstract Full Text PDF[1M]
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Original Article
Maltosyltrehalose Syrup: Bacterial reverse mutation test, and 90-day feeding and 90-day repeated oral dose toxicity studies in rats Vol.7, No.3, p.141-152
Shuji Matsumoto , Takaharu Hashimoto , Chie Ushio , Keisuke Namekawa , Alan B. Richards
Released: April 22, 2020
Abstract Full Text PDF[1M]
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Original Article
Sex differences in the effects of high-fat diet on mouse sciatic nerves Vol.7, No.3, p.133-139
Masahiro Ogawa , Takahiro Kimura , Yoshitaka Tanetani , Masami Hori , Takahiro Kyoya , Megumi Terada
Released: April 15, 2020
Abstract Full Text PDF[1M]
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Original Article
In vitro toxicity studies of epoxyoleic acid and diepoxylinoleic acid Vol.7, No.3, p.123-132
Takashi Kitaguchi , Masaharu Tanaka , Takahiro Matsuda , Taisei Mizota , Katsutoshi Ohno , Kazuhiro Kobayashi , Yasumitsu Ogra , Mitsuru Tanaka
Released: April 15, 2020
Abstract Full Text PDF[5M]
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Letter
Effects of estrogen on fatty-acid-induced cytotoxicity in mouse Neuro-2a neural cells Vol.7, No.2, p.115-121
Masahiro Ogawa , Takahiro Kyoya , Takahiro Kimura , Megumi Terada
Released: March 27, 2020
Abstract Full Text PDF[1M]
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Original Article
Evaluation of cytokine storms in a disseminated intravascular coagulation monkey model Vol.7, No.2, p.105-114
Yoshitaka Hirasawa , Atsushi Fujiwara , Kazuya Tabata , Kenji Yoshida , Tsutomu Negama , Takayuki Anzai , Shin-ichi Sato
Released: March 27, 2020
Abstract Full Text PDF[2M]
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Original Article
5-Fluorocytosine induces fetal skeletal malformations in rats by altering expression of Homeobox genes Vol.7, No.2, p.97-103
Takayuki Kumamoto , Mika Senuma , Mai Todoroki , Fumiaki Kumagai , Hajime Imai , Reiko Suzuki , Tetsuo Ogawa , Makiko Kuwagata
Released: March 27, 2020
Abstract Full Text PDF[2M]
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Original Article
Utility of measuring long bone length in toxicity studies: results of a 14-day repeated dose oral toxicity study of dexamethasone in young, periadolescent and adult rats Vol.7, No.2, p.85-96
Chihiro Noguchi , Satoshi Tsuji , Yutaka Nakanishi , Minoru Sasaki
Released: March 03, 2020
Abstract Full Text PDF[6M]
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Original Article
Arsenite inhibits gene expression of perlecan, syndecan-1, -2, -3 and biglycan in cultured vascular endothelial cells Vol.7, No.2, p.77-83
Dong-pan Wu , Tsuyoshi Nakano , Yayoi Tsuneoka , Tsutomu Takahashi , Yo Shinoda , Toshiyuki Kaji , Yasuyuki Fujiwara
Released: March 03, 2020
Abstract Full Text PDF[1M]
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Original Article
Toxicological evaluation of DSPC (1,2-distearoyl-sn-glycero-3-phosphocholine) Vol.7, No.2, p.55-76
Osamu Ohgoda , Ian N. Robinson
Released: March 03, 2020
Abstract Full Text PDF[1009K]
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Original Article
Comparison of the liver findings after simvastatin-treatment between Spontaneously Diabetic Torii-Leprfa (SDT fatty) rats and Sprague-Dawley rats Vol.7, No.1, p.41-54
Tadakazu Takahashi , Yusuke Suzuki , Naohito Yamada , Kaoru Toyoda , Keisuke Goda , Katsunori Ryoke , Chizuru Matsuura , Akio Kobayashi , Shoichiro Sugai , Kayoko Shimoi
Released: January 28, 2020
Abstract Full Text PDF[3M]
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Original Article
Triphenyltin inhibits GA-binding protein α nuclear translocation Vol.7, No.1, p.33-40
Naohiro Kidoguchi , Keishi Ishida , Seigo Sanoh , Masatsugu Miyara , Yaichiro Kotake
Released: January 23, 2020
Abstract Full Text PDF[2M]
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Original Article
Safety and efficacy of a 48-week long-term ingestion of D-allulose in subjects with high LDL cholesterol levels Vol.7, No.1, p.15-31
Misuzu Tanaka , Akane Kanasaki , Noriko Hayashi , Tetsuo Iida , Koji Murao
Released: January 17, 2020
Abstract Full Text PDF[894K]
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Letter
Usefulness and limitations of mRNA measurement in HepaRG cells for evaluation of cytochrome P450 induction Vol.7, No.1, p.9-14
Kenta Mizoi , Yuuki Fukai , Eiko Matsumoto , Satoshi Koyama , Seiichi Ishida , Hajime Kojima , Takuo Ogihara
Released: January 15, 2020
Abstract Full Text PDF[1M]
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Original Article
Azoxystrobin at sub-cytotoxic concentrations disrupts intracellular zinc homeostasis: A flow cytometric analysis with rat thymic lymphocytes and fluorescent probes Vol.7, No.1, p.1-7
Mai Shoji , Masaki Asada , Akihiko Matsumoto , Haruki Nishino , Ao Yi Xiang , Mizuki Mizobuchi , Naoki Kanematsu , Hajime Miura , Norio Kamemura
Released: January 10, 2020
Abstract Full Text PDF[3M]
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2019 - Vol. 6

Original Article
Obesity-related hypertension and enhanced plasma orexin-A level are attenuated by the consumption of thiamine water in diabetic rats under cerebral oxidative stress conditions Vol.6, No.9, p.383-390
Yuka Kohda , Hitoshi Matsumura
Released: December 27, 2019
Abstract Full Text PDF[2M]
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Original Article
Safety evaluation of chicken breast meat extract in chromosomal aberration study, reverse mutation test, and 90-day repeated dose study in rats Vol.6, No.9, p.367-382
Yuasa Koki , Tadashi Imamura , Yasue Sakaguchi , Satoshi Kotoura
Released: December 19, 2019
Abstract Full Text PDF[2M]
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Original Article
Phospholipid and Triglyceride keep vortex-dispersed sulfur mustard analog as undissolved droplets which induce necrosis from nearby cells via declining mitochondrial membrane potential Vol.6, No.9, p.359-366
Feng Ye , Guorong Dan , Qinya Zeng , Mingliang Chen , Yuanpeng Zhao , Jin Cheng , Yan Sai , Jiqing Zhao , Zhongmin Zou
Released: December 13, 2019
Abstract Full Text PDF[6M]
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Original Article
Safety assessment of isomaltodextrin-producing enzymes from Paenibacillus alginolyticus Vol.6, No.9, p.341-357
Tsuyoshi Sadakiyo , Hikaru Watanabe , Hitoshi Mitsuzumi , Shimpei Ushio , Mai Sugi , Masakatsu Natsume
Released: December 11, 2019
Abstract Full Text PDF[1M]
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Original Article
Assessment of the acute toxicity of 16 veterinary drugs and a disinfectant to aquatic and soil organisms Vol.6, No.9, p.333-340
Noriko Usui , Masahito Ohara , Masaya Ito , Atsushi Noda , Yoshihiko Ito , Norio Hirayama
Released: December 11, 2019
Abstract Full Text PDF[1M]
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Original Article
Development of a hepatotoxicity prediction model using in vitro assay data of key molecular events Vol.6, No.8, p.327-332
Koji Jojima , Takashi Yamada , Akihiko Hirose
Released: December 11, 2019
Abstract Full Text PDF[925K]
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Original Article
Sulforaphane displays the growth inhibition, cytotoxicity and enhancement of retinoic acid-induced superoxide-generating activity in human monoblastic U937 cells Vol.6, No.8, p.319-325
Sumiko Akiyoshi , Hidehiko Kikuchi , Futoshi Kuribayashi , Harishkumar Madhyastha , Hisanori Minami
Released: December 11, 2019
Abstract Full Text PDF[1M]
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Original Article
Glucosyl hesperidin: safety studies Vol.6, No.8, p.299-317
Shuji Matsumoto , Takaharu Hashimoto , Chie Ushio , Keisuke Namekawa , Alan Blake Richards
Released: November 18, 2019
Abstract Full Text PDF[1M]
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Original Article
Carbamazepine-induced liver injury using type 2 diabetes Spontaneously Diabetic Torii-Leprfa (SDT fatty) rats as a model for human type 2 diabetes Vol.6, No.8, p.287-297
Tadakazu Takahashi , Chizuru Matsuura , Kaoru Toyoda , Yusuke Suzuki , Naohito Yamada , Akio Kobayashi , Shoichiro Sugai , Kayoko Shimoi
Released: November 18, 2019
Abstract Full Text PDF[4M]
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Letter
Transmission electron microscopy of the benzbromaroneinduced change in mitochondrial morphology in HepG2 cells Vol.6, No.8, p.281-286
Tomoyuki Sato , Akinori Takemura , Yugo Ikeyama , Yuriko Sakamaki , Ayako Mimata , Haruyo Aoyagi , Hideki Aizaki , Shuichi Sekine , Kousei Ito
Released: October 25, 2019
Abstract Full Text PDF[4M]
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Letter
A carrier protein is essential for the action of silver nanoparticles in an animal experiment Vol.6, No.7, p.277-279
Masami Ishido
Released: October 21, 2019
Abstract Full Text PDF[1M]
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Original Article
A 6-week repeated intranasal dose toxicity study of TTA-121, a novel oxytocin nasal spray, in cynomolgus monkeys Vol.6, No.7, p.269-275
Emi Matsumoto , Junichi Namekawa , Hideshi Kaneko , Takasumi Shimomoto , Mitsuaki Masuyama , Toshihisa Fujiwara , Daishiro Miura
Released: October 19, 2019
Abstract Full Text PDF[2M]
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Original Article
A 6-week repeated intranasal dose toxicity study of TTA-121, a novel oxytocin nasal spray, in rats Vol.6, No.7, p.259-268
Junichi Namekawa , Emi Matsumoto , Hideshi Kaneko , Takasumi Shimomoto , Takayuki Okamura , Takafumi Oshikata , Roger A. Renne , Daishiro Miura
Released: October 19, 2019
Abstract Full Text PDF[3M]
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Letter
Impact of dietary calcium and phosphorus levels on an ovariectomized Sprague-Dawley rat model of osteoporosis Vol.6, No.7, p.253-258
Atsushi Watanabe , Katsuhiro Miyajima , Noriko Kemuriyama , Hisashi Uchiyama , Takayuki Anzai , Hijiri Iwata , Reo Anzai , Dai Nakae
Released: October 11, 2019
Abstract Full Text PDF[4M]
Supplemental Data
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Letter
Localization of the trichloroethylene-related compound S-(1, 2-dichlorovinyl)-L-cysteine in mouse cartilage Vol.6, No.7, p.249-252
Norikazu Komoriya , Nobuaki Shirai , Hiroki Tomisawa , Hiromi Hagiwara
Released: October 09, 2019
Abstract Full Text PDF[1M]
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Letter
Comparison of cytotoxicity between fixed- and unfixed-combination ophthalmic solutions in vitro Vol.6, No.7, p.245-248
Kazuyo Sadamoto , Shingo Nemoto , Akio Kawamura , Masaaki Kurata
Released: October 09, 2019
Abstract Full Text PDF[795K]
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Original Article
High-dose β-carotene exacerbates high-fat/high-sucrose diet-inducible fibrosis in the liver of Mongolian gerbils Vol.6, No.6, p.235-243
Shinnosuke Kondo , Natsuyo Hariya , Kazuki Mochizuki
Released: September 20, 2019
Abstract Full Text PDF[4M]
Supplemental Data
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Original Article
Safety evaluation of 12-week continuous ingestion of D-allulose in borderline diabetes and type 2 diabetes Vol.6, No.6, p.225-234
Misuzu Tanaka , Noriko Hayashi , Tetsuo Iida
Released: September 20, 2019
Abstract Full Text PDF[845K]
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Original Article
Recovery of increased weights of the liver and kidneys by cessation of D-allulose feeding in Wistar rats Vol.6, No.6, p.217-224
Masaru Ochiai , Kei Ohkubo , Masako Nakamura , Takako Yamada , Tetsuo Iida , Tatsuhiro Matsuo
Released: September 05, 2019
Abstract Full Text PDF[3M]
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Original Article
Procyanidin protects HK-2 cells against cisplatin-induced injury through antioxidant action involving Nrf2/HO-1 signaling pathway Vol.6, No.6, p.207-215
Cheng Chen , Xi Feng , Ran Jing , Yushang Tang , Wanfen Zhang , Tongqiang Liu
Released: September 05, 2019
Abstract Full Text PDF[3M]
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Original Article
Multi-site study of an in vivo phototoxicity evaluation in Sprague-Dawley (SD) rats aimed at incorporating the phototoxicity assessments: effects of repeated administration and toxicokinetic blood collection on drug-induced phototoxicity Vol.6, No.6, p.197-206
Yutaka Yonezawa , Hitoshi Katou , Kazuhiro Kuga
Released: August 27, 2019
Abstract Full Text PDF[2M]
Supplemental Data
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Letter
Oral toxicity study of an antiprion compound N,N’-[(cyclohexylmethylene)di-4,1-phenylene]bis[2-(1-pyrrolidinyl) acetamide] in rats and cynomolgus monkeys Vol.6, No.5, p.187-195
Junji Hosokawa-Muto , Tsutomu Kimura , Kazuo Kuwata
Released: August 01, 2019
Abstract Full Text PDF[1M]
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Original Article
Species difference in antimony and arsenic metabolism between hamster and rat after administration of tri- or pentavalent inorganic antimony Vol.6, No.5, p.181-185
Quan Zhou , Yu-ki Tanaka , Noriyuki Suzuki , Yasumitsu Ogra
Released: August 01, 2019
Abstract Full Text PDF[1M]
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Original Article
Multi-site study of an in vivo phototoxicity evaluation in Sprague-Dawley rats: skin site and sex differences in sensitivity to drug-induced phototoxicity Vol.6, No.5, p.171-179
Kazuhiro Kuga , Yutaka Yonezawa , Hitoshi Katou
Released: August 01, 2019
Abstract Full Text PDF[2M]
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Letter
Methylmercury causes neuronal cell death via M1-microglial activation in organotypic slices prepared from mouse cerebral cortex Vol.6, No.5, p.167-170
Takayuki Hoshi , Takashi Toyama , Akira Naganuma , Gi-Wook Hwang
Released: July 02, 2019
Abstract Full Text PDF[2M]
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Original Article
Comprehensive toxicity evaluation of cyclopentyl methyl ether (CPME) for establishing a permitted daily exposure level Vol.6, No.5, p.145-165
Kaoru Inoue , Hiroshi Suzuki , Takashi Yamada
Released: June 25, 2019
Abstract Full Text PDF[1017K]
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Letter
Genotoxicity evaluation of oil prepared from the internal organs of the Japanese giant scallop (Patinopecten yessoensis) Vol.6, No.4, p.137-143
Koki Sugimoto , Ryota Hosomi , Kenji Fukunaga , Takaki Shimono , Seiji Kanda , Toshimasa Nishiyama , Munehiro Yoshida , Takeya Yoshioka , Koretaro Takahashi
Released: June 13, 2019
Abstract Full Text PDF[797K]
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Original Article
Validation of the statistical parameters and model selection criteria of the benchmark dose methods for the evaluation of various endpoints in repeated-dose toxicity studies Vol.6, No.4, p.125-136
Mariko Matsumoto , Mutsuko Hirata-Koizumi , Tomoko Kawamura , Sawako Sakuratani , Atsushi Ono , Akihiko Hirose
Released: May 17, 2019
Abstract Full Text PDF[7M]
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Toxicomics Report
Gene expression profiles of immortalized S1, S2, and S3 cells derived from each segment of mouse kidney proximal tubules Vol.6, No.4, p.117-123
Hitomi Fujishiro , Seiichiro Himeno
Released: May 14, 2019
Abstract Full Text PDF[746K]
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Letter
Impairment of fertilization efficiency in mice following nano-sized titanium exposure Vol.6, No.3, p.113-116
Nobuhiko Miura , Katsumi Ohtani , Tatsuya Hasegawa , Gi-Wook Hwang , Hiroki Yoshioka
Released: May 14, 2019
Abstract Full Text PDF[914K]
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Letter
Magnoliae Cortex extract protects PC12 cells from cytotoxicity induced by hydrogen peroxide or 6-hydroxydopamine through enzyme induction Vol.6, No.3, p.107-112
Takahito Nishiyama , Yasuhiro Masuda , Tadashi Izawa , Tomokazu Ohnuma , Kenichiro Ogura , Akira Hiratsuka
Released: April 24, 2019
Abstract Full Text PDF[1M]
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Original Article
Genotoxicity and subchronic toxicity studies of Taiwanofungus camphoratus extract Vol.6, No.3, p.81-106
Jian-Yu Lin , Mei-Chun Chen , Emerson Chiu
Released: April 05, 2019
Abstract Full Text PDF[2M]
Supplemental Data
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Original Article
Age-dependent aggravation of oral malodor and periodontal disease in dogs Vol.6, No.3, p.75-79
Naoki Iwashita , Kazutoshi Sugita , Sayaka Murata , Keiko Ichimura , Mitsuyuki Shirai , Masaharu Hisasue , Miyoko Saito , Takuma Aoki , Yukihiko Takagi , Fumitoshi Asai
Released: April 04, 2019
Abstract Full Text PDF[743K]
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Original Article
Twenty-eight-day oral toxicity study of L-hydroxyproline in rats with 14-day post-treatment observation period Vol.6, No.3, p.65-74
Saori Akiduki , Yoko Kawada , Fumiko Watanabe , Toshikazu Kamiya , Koji Morishita
Released: April 04, 2019
Abstract Full Text PDF[1M]
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Original Article
Effects of benzotriazole ultraviolet stabilizers on rat PXR, CAR and PPARα transcriptional activities Vol.6, No.2, p.57-63
Yoko Watanabe , Shoko Hattori , Chieri Fujino , Ken Tachibana , Hiroyuki Kojima , Kouichi Yoshinari , Shigeyuki Kitamura
Released: March 19, 2019
Abstract Full Text PDF[1M]
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Original Article
Cytotoxic effects of parathion, paraoxon, and their methylated derivatives on a mouse neuroblastoma cell line NB41A3 Vol.6, No.2, p.45-56
Yunbiao Wang , ByungHoon Kim , Ashley Walker , Shayla Williams , Ashley Meeks , Yong-Jin Lee , Seong S. Seo
Released: March 12, 2019
Abstract Full Text PDF[2M]
Supplemental Data
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Original Article
Acute hepatotoxicity and drug/chemical interaction toxicity of 10-nm silver nanoparticles in mice Vol.6, No.2, p.37-44
Katsuhiro Isoda , Naoki Kobayashi , Yuichiro Taira , Ikuko Taira , Yoshimi Shimizu , Yoshihiro Akimoto , Hayato Kawakami , Isao Ishida
Released: March 06, 2019
Abstract Full Text PDF[4M]
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Toxicomics Report
Effects of lithium on developmental toxicity, teratogenicity and transcriptome in medaka embryos Vol.6, No.2, p.31-36
Nobuaki Tominaga , Seiya Shino , Masaya Uchida , Hiroshi Ishibashi , Midori Iida , Tadashi Okobira , Kayla Arizono , Noriaki Yoshida , Koji Arizono
Released: February 15, 2019
Abstract Full Text PDF[2M]
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Letter
Protective effect of the Kampo formula “Juzen-taiho-to” on isoniazid- and rifampicin-induced hepatotoxicity in mice Vol.6, No.1, p.25-29
Hiroki Yoshioka , Shiori Fukaya , Sarah Tominaga , Akito Nagatsu , Nobuhiko Miura , Tohru Maeda
Released: February 06, 2019
Abstract Full Text PDF[1M]
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Original Article
Supplementation with lower doses of EGCg reduces liver injury markers of type 2 diabetic rats Vol.6, No.1, p.15-23
Kazuki Mochizuki , Yu Tan , Yumiko Uchiyama , Takuji Suzuki , Natsuyo Hariya , Toshinao Goda
Released: January 30, 2019
Abstract Full Text PDF[1M]
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Letter
Investigation of DNA damage of glycidol and glycidol fatty acid esters using Fpg-modified comet assay Vol.6, No.1, p.9-14
Ryo Inagaki , Kohei Uchino , Yuko Shimamura , Shuichi Masuda
Released: January 18, 2019
Abstract Full Text PDF[2M]
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Original Article
Thiamine supplementation modulates oxidative stress by inhibiting hepatic adenosine diphosphate (ADP)-ribosylation in obese diabetic rats Vol.6, No.1, p.1-8
Yuka Kohda , Junpei Ueda , Rie Azuma , Yuuka Nakatani , Hiroto Murase , Kanta Matsui , Yuka Takezoe , Eiko Nagata , Risa Matsui , Takao Tanaka , Hitoshi Matsumura
Released: January 16, 2019
Abstract Full Text PDF[2M]
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2018 - Vol. 5

Toxicomics Report
Cyclin-dependent kinase inhibitor p21/Cip1 down-regulates the expression of proteasome activator PA28γ in normal hepatocyte-derived cells Vol.5, No.6, p.203-207
Tomofumi Fujino , Toshiyuki Oshima , Makio Hayakawa
Released: December 28, 2018
Abstract Full Text PDF[1M]
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Minireview
The temporal turning window for rat behavioral phenotypes by rotenone Vol.5, No.6, p.195-202
Masami Ishido
Released: December 28, 2018
Abstract Full Text PDF[13M]
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Original Article
Study of metabolic activation of the UV-filter octyl methoxycinnamate for endocrine-disrupting activity Vol.5, No.6, p.185-193
Yoko Watanabe , Chihiro Emori , Naoto Uramaru , Nariaki Fujimoto , Shigeyuki Kitamura
Released: December 18, 2018
Abstract Full Text PDF[1M]
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Letter
A zinc complex that suppresses the expression of a reactive sulfur species-producing enzyme, cystathionine γ-lyase, in cultured vascular endothelial cells Vol.5, No.6, p.181-184
Akane Takahashi , Musubu Takahashi , Tomoya Fujie , Takato Hara , Eiko Yoshida , Chika Yamamoto , Toshiyuki Kaji
Released: December 11, 2018
Abstract Full Text PDF[2M]
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Original Article
Effects of fish oil-enriched Sasa-kamaboko diet in decreasing hepatic lipid levels in a mouse fatty liver disease model Vol.5, No.5, p.171-179
Masaaki Miyata , Tomoki Kinoshita , Kaho Miyahara , Mizuki Sato , Asaka Arikawa , Yoshimasa Sugiura , Yoshihisa Suzuki , Emiko Okazaki
Released: November 21, 2018
Abstract Full Text PDF[2M]
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Original Article
Derivation of acceptable daily exposure value for alanine, N,N-bis(carboxymethyl)-, trisodium salt Vol.5, No.5, p.167-170
Masayuki Mishima , Dana Hoffmann , Gaku Ichihara , Satoshi Kitajima , Makoto Shibutani , Satoshi Furukawa , Akihiko Hirose
Released: November 06, 2018
Abstract Full Text PDF[794K]
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Letter
Protection from acetaminophen-induced hepatotoxicity by post-administration of 1O, 20O-diacetyl kamebakaurin in mice Vol.5, No.5, p.161-165
Hiroki Yoshioka , Hiroyuki Ohnishi , Masae Yoshikawa , Ming-Yu Gui , Yong-Ri Jin , Xu-Wen Li , Yoshiyuki Adachi , Naohito Ohno , Koichi Takeya , Yukio Hitotsuyanagi , Nobuhiko Miura , Yutaka Aoyagi
Released: October 19, 2018
Abstract Full Text PDF[3M]
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Original Article
In utero exposure to 2,2’,4,4’,5,5’-hexachlorobiphenyl accelerates the onset of eye opening in rat offspring Vol.5, No.4, p.153-159
Kenichi Kobayashi , Muneyuki Miyagawa , Rui-Sheng Wang , Megumi Suda , Soichiro Sekiguchi , Takeshi Honma
Released: October 16, 2018
Abstract Full Text PDF[1M]
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Letter
Positions and numbers of hydroxyl groups in hydroxychalcone derivatives are involved in cytotoxicity against human monoblastic U937 cells Vol.5, No.4, p.149-152
Hidehiko Kikuchi , Futoshi Kuribayashi , Harishkumar Madhyastha
Released: September 29, 2018
Abstract Full Text PDF[929K]
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Original Article
Anatomical and histological sex differences in the eye and its accessory tissues in Dutch belted rabbits Vol.5, No.4, p.141-147
Gakushi Kito , Ikuyo Atsumi , Yoshinori Yamagiwa , Hideyuki Sakaki , Masaaki Kurata
Released: July 18, 2018
Abstract Full Text PDF[611K]
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Original Article
Carcinogenicity study of poly-trans-[(2-carboxyethyl)germasesquioxane] (Ge-132) in F344 rats Vol.5, No.4, p.127-140
Katsuharu Iwadate , Yukari Yamaguchi , Mai Sasaki , Mikiya Nakatani , Yuko Doi , Norio Imai , Seiko Tamano , Yorifumi Nishihori
Released: July 10, 2018
Abstract Full Text PDF[423K]
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Letter
The impact on the activity of acetylcholinesterase of a polylysine-ApoE peptide carrier targeting the blood brain barrier Vol.5, No.4, p.123-126
Toby M. Michelena , Xuechen Tian , Xuan Zhou , Yu Meng
Released: July 03, 2018
Abstract Full Text PDF[212K]
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Letter
Chlorella supplementation decreases methylmercury concentrations of hair and blood in healthy volunteers Vol.5, No.3, p.117-122
Isao Maruyama , Takuya Uchikawa , Toshihiro Kanno , Yotaro Ando , Hisao Kitsuki , Akira Yasutake
Released: June 22, 2018
Abstract Full Text PDF[350K]
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Letter
In vitro metabolism of 4-methyl- and 5-methyl-2-mercaptobenzimidazole, thyrotoxic and hepatotoxic rubber antioxidants, in rat liver microsomes Vol.5, No.3, p.113-116
Atsuko Miyajima , Yukie Kuroda , Kazue Sakemi-Hoshikawa , Makoto Usami , Katsuyoshi Mitsunaga , Tomohiko Irie , Yasuo Ohno , Momoko Sunouchi
Released: June 19, 2018
Abstract Full Text PDF[728K]
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Original Article
The Kampo formula “Juzen-taiho-to” exerts protective effects on ethanol-induced liver injury in mice Vol.5, No.3, p.105-112
Shiori Fukaya , Akito Nagatsu , Hiroki Yoshioka
Released: June 19, 2018
Abstract Full Text PDF[5M]
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Original Article
Biphenyl increases the intracellular Ca2+ concentration in HL-60 cells Vol.5, No.3, p.99-103
Tomoko Inubushi , Mayumi Sugimoto , Haruka Kunimi , Haruka Hino , Atsushi Tabata , Naohiro Imura , Shin Abe , Norio Kamemura
Released: June 01, 2018
Abstract Full Text PDF[305K]
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Letter
Effect of heat shock protein gene expression on cadmium toxicity in human proximal tubular cells Vol.5, No.3, p.93-97
Jin-Yong Lee , Maki Tokumoto , Gi-Wook Hwang , Masahiko Satoh
Released: May 30, 2018
Abstract Full Text PDF[594K]
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Original Article
Cadmium, arsenic and lead accumulation in rice grains produced in Senegal river valley Vol.5, No.2, p.87-91
Moussa Ndong , Nathan Mise , Masaki Okunaga , Fujio Kayama
Released: May 22, 2018
Abstract Full Text PDF[206K]
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Letter
Risk assessment of reproductive and developmental toxicity in eye-drop drugs: a consideration based on threshold of toxicological concern Vol.5, No.2, p.83-85
Masaaki Kurata , Gakushi Kito , Kazuyo Sadamoto , Shingo Nemoto
Released: April 25, 2018
Abstract Full Text PDF[455K]
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Letter
Male-specific prolongation of prothombin time by industrial chemicals Vol.5, No.2, p.75-82
Takashi Yamada , Yushiro Tanaka , Ryuichi Hasegawa , Toshime Igarashi , Akihiko Hirose
Released: April 18, 2018
Abstract Full Text PDF[1M]
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Toxicomics Report
Putrescine selectively alleviates methylmercury toxicity in C17.2 mouse neural stem cells Vol.5, No.2, p.71-73
Masayuki Sato , Jin-Yong Lee , Min-Seok Kim , Tsutomu Takahashi , Akira Naganuma , Gi-Wook Hwang
Released: April 18, 2018
Abstract Full Text PDF[906K]
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Letter
Assessment of bladder DNA damage due to 2-acetylaminofluorene, diuron, and terephthalic acid by the rat comet assay Vol.5, No.1, p.63-69
Takahiro Kyoya , Rika Iwamoto , Yuko Shimamura , Megumi Terada , Shuichi Masuda
Released: March 20, 2018
Abstract Full Text PDF[801K]
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Letter
Scanning electron microscopic analysis of the bladder epithelium in terephthalic acid administered rats: a case in acute toxicity study Vol.5, No.1, p.57-62
Takahiro Kyoya , Megumi Terada
Released: March 09, 2018
Abstract Full Text PDF[3M]
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Original Article
Abundant migration of midazolam and 1’-hydroxymidazolam into the fetal brain following midazolam administration to pregnant mice in the second trimester Vol.5, No.1, p.49-56
Satoshi Kitaoka , Jo Hatogai , Nanako Niikura , Miho Hirata , Nanako Fukasawa , Satoru Miyazaki , Naoto Yamaguchi , Shohei Harada , Masanaho Sasatsu , Kiyoshi Sugiyama , Wataru Ochiai
Released: March 07, 2018
Abstract Full Text PDF[513K]
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Original Article
Subacute toxicity evaluation of KMRC011, a Toll-like receptor-5 agonist administered by intramuscular injection to rats Vol.5, No.1, p.33-48
Min-Sung Kang , Min-Seok Kim , Sung-Hwan Kim , Doin Jeon , Hyeon-Young Kim , Kwang-Hyun Lim , Su-Cheol Han , Kyuhong Lee , Woo-Jong Lee , Chi-Min Choi , Hong-Soo Lee , Jong-Choon Kim
Released: March 07, 2018
Abstract Full Text PDF[3M]
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Original Article
Comparison of stabilities of nitrenium ions and in vitro and in vivo genotoxic potential, between four aniline derivatives Vol.5, No.1, p.21-32
Hidekazu Suzuki , Takuya Ninoseki , Ayumi Hayashi , Yasunori Hase , Takuya Matsui , Masaru Naito , Shoichiro Sugai
Released: February 21, 2018
Abstract Full Text PDF[255K]
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Original Article
Increased hepatic triglyceride level induced by a glucokinase activator in mice Vol.5, No.1, p.13-20
Junichi Namekawa , Mari Yasui , Atsuko Katayanagi , Mitsuyuki Shirai , Fumitoshi Asai
Released: February 06, 2018
Abstract Full Text PDF[1M]
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Original Article
A 28-day repeated oral-dose toxicity study of insecticide synergist N-(2-ethylhexyl)-1-isopropyl-4-methylbicyclo[2.2.2] oct-5-ene-2,3-dicarboximide in rats Vol.5, No.1, p.1-11
Mariko Matsumoto , Masatoshi Furukawa , Katsumi Kobayashi , Takako Iso , Toshime Igarashi , Takashi Yamada , Akihiko Hirose
Released: January 19, 2018
Abstract Full Text PDF[254K]
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2017 - Vol. 4

Original Article
General toxicity of a vitamin K1 2,3-epoxide reductase (VKOR) inhibitor, 3-acetyl-5-methyltetronic acid, in rats Vol.4, No.6, p.285-293
Masashi Uchida , Yuka Sakaguchi , Yohei Miyamoto
Released: December 26, 2017
Abstract Full Text PDF[597K]
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Original Article
Hepatic glucose-dependent insulinotropic polypeptide expression is modified by supplementing high-dose thiamine in obese diabetic rats Vol.4, No.6, p.279-284
Yuka Kohda , Akie Maekita , Takao Tanaka , Hitoshi Matsumura
Released: December 21, 2017
Abstract Full Text PDF[1M]
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Letter
Effect of chronic cadmium exposure on the gene expression of Birc family in the mouse kidney and liver Vol.4, No.6, p.275-278
Jin-Yong Lee , Maki Tokumoto , Gi-Wook Hwang , Masahiko Satoh
Released: December 21, 2017
Abstract Full Text PDF[1M]
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Original Article
Effect of metallothionein on ethanol-induced hepatotoxicity in mice Vol.4, No.6, p.269-273
Maki Tokumoto , Kiyoshi Shibuya , Jin-Yong Lee , Chiharu Tohyama , Masahiko Satoh
Released: December 15, 2017
Abstract Full Text PDF[1M]
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Original Article
Suppressive effect of Sasa veitchii extract on obesity induced by a high-fat diet through modulation of adipose differentiation in mice Vol.4, No.6, p.261-268
Hiroki Yoshioka , Mihoko Mori , Masae Yoshikawa , Hirohisa Fujii , Akito Nagatsu , Tsunemasa Nonogaki
Released: December 13, 2017
Abstract Full Text PDF[1M]
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Original Article
Toxicity of repeated 28-day oral administration of acenaphthylene in rats Vol.4, No.6, p.247-259
Shihori Tanabe , Katsumi Kobayashi , Mariko Matsumoto , Hideki Serizawa , Toshime Igarashi , Takashi Yamada , Akihiko Hirose
Released: November 07, 2017
Abstract Full Text PDF[219K]
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Letter
In vitro genotoxicity test package of antibiotics for human use submitted to the Japanese regulatory agency during 2004–2015 Vol.4, No.5, p.241-245
Shin-ichi Sekizawa , Yukiko Hoshino , Aiko Takasu
Released: October 18, 2017
Abstract Full Text PDF[306K]
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Original Article
CYP3A4 induction mechanism of polycyclic aromatic hydrocarbons differs from that of rifampicin in PXR binding element Vol.4, No.5, p.229-239
Yusuke Aratsu , Reo Odagiri , Rie Shoji , Kouki Watanabe , Takeshi Kumagai , Sawako Shindo , Takamitsu Sasaki , Kiyoshi Nagata
Released: October 05, 2017
Abstract Full Text PDF[909K]
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Original Article
A 4-week oral gavage toxicity study of L-citrulline in rats Vol.4, No.5, p.219-227
Masahiko Morita , Tsuyoshi Yamaguchi , Koji Morishita , Ayako Kamimura
Released: September 27, 2017
Abstract Full Text PDF[680K]
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Original Article
Toxicity in repeated 28-day oral administration of N-phenyl-1-naphthylamine in rats Vol.4, No.5, p.207-218
Shihori Tanabe , Masahito Ohara , Masaya Ito , Atsushi Noda , Katsumi Kobayashi , Mariko Matsumoto , Akihiko Hirose
Released: September 13, 2017
Abstract Full Text PDF[211K]
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Letter
Organophosphorus insecticide dichlorvos inhibits fatty acid amide hydrolase in the male reproductive organs of rats Vol.4, No.5, p.201-205
Naoko Oya , Yuki Ito , Michihiro Kamijima
Released: August 30, 2017
Abstract Full Text PDF[1M]
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Toxicomics Report
Expression levels of 39 Cyp mRNAs in the mouse brain and neuroblastoma cell lines, C-1300N18 and NB2a – strong expression of Cyp1b1 Vol.4, No.5, p.195-200
Satoshi Yamaori , Rongrong Jiang , Chikako Maeda , Risa Ogawa , Hiroyuki Okazaki , Hironori Aramaki , Kazuhito Watanabe
Released: August 24, 2017
Abstract Full Text PDF[184K]
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Letter
A new insight into proliferative action of bisphenol A at low-dose Vol.4, No.4, p.191-193
Masami Ishido , Rumiko Usu
Released: July 22, 2017
Abstract Full Text PDF[219K]
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Letter
HSP70-Ran-RCC1 transport system during cadmium-induced apoptosis in porcine kidney LLC-PK1 cells Vol.4, No.4, p.187-189
Masami Ishido , Rumiko Usu
Released: July 22, 2017
Abstract Full Text PDF[482K]
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Original Article
Disposition of perfluorododecanoic acid in male rats after oral administration Vol.4, No.4, p.179-186
Kohei Kawabata , Suzuka Tamaki , Eri Kokubo , Yukari Kobayashi , Tomoya Shinohara , Ayako Sakai , Hiroshi Kawai , Atsushi Mitsumoto , Yoichi Kawashima , Naomi Kudo
Released: July 20, 2017
Abstract Full Text PDF[394K]
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Letter
Cytometric analysis on cytotoxicity of 4,4′-methylenediphenyl diisocyanate, a chemical allergen, in rat thymocytes Vol.4, No.4, p.173-178
Keisuke Oyama , Norikazu Miyoshi , Yasuo Oyama
Released: July 08, 2017
Abstract Full Text PDF[1M]
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Letter
Predicting clinical cardiotoxicity caused by trastuzumab and E-8010 using human cardiomyocytes Vol.4, No.4, p.167-171
Nobuo Aikawa
Released: July 04, 2017
Abstract Full Text PDF[216K]
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Original Article
Distinct regulation of nuclear localization of caspase-activated DNase during cadmium-induced apoptosis of the target cells Vol.4, No.3, p.159-165
Masami Ishido , Rumiko Usu
Released: June 30, 2017
Abstract Full Text PDF[1M]
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Original Article
Orally administered p-nitrotoluene causes hyperactivity, concomitant with gliosis and impairment of tyrosine hydroxylase immunoreactivity in the rat substantia nigra Vol.4, No.3, p.151-158
Masami Ishido , Rumiko Usu
Released: June 30, 2017
Abstract Full Text PDF[1M]
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Original Article
No carcinogenicity of poly-trans-[(2-carboxyethyl) germasesquioxane] (Ge-132): 26-week feeding study using rasH2 mice Vol.4, No.3, p.137-150
Yuko Doi , Norio Imai , Mayuko Suguro , Takamasa Numano , Fumio Furukawa
Released: June 28, 2017
Abstract Full Text PDF[883K]
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Letter
The utility of human iPS cell-derived cardiomyocytes in predicting the clinical risk of drugs that display discordance of cardiotoxicity by species Vol.4, No.3, p.127-136
Nobuo Aikawa
Released: June 23, 2017
Abstract Full Text PDF[474K]
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Original Article
Utility of murine dendritic cell line DC2.4 for in vitro assay of skin-sensitization potential Vol.4, No.3, p.121-126
Erina Shiraishi , Akiko Ido , Youhei Hiromori , Kento Tanaka , Tomoki Kimura , Hisamitsu Nagase , Tsuyoshi Nakanishi
Released: June 09, 2017
Abstract Full Text PDF[766K]
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Letter
Permeability of skin to silver nanoparticles after epidermal skin barrier disruption in rats Vol.4, No.3, p.109-119
Makiko Kuwagata , Fumiaki Kumagai , Yoshiaki Saito , Kazuma Higashisaka , Yasuo Yoshioka , Yasuo Tsutsumi
Released: June 09, 2017
Abstract Full Text PDF[2M]
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Letter
A study for finding new phototoxicity descriptors related to potential energy Vol.4, No.3, p.105-107
Yu Haranosono , Shingo Nemoto , Masaaki Kurata , Hideyuki Sakaki
Released: June 02, 2017
Abstract Full Text PDF[359K]
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Letter
Phytocannabinoids, Δ9-tetrahydrocannabinol and cannabidiol, as human calpain-1 (CAPN1) activators Vol.4, No.2, p.101-103
Shuso Takeda , Kazuhito Watanabe , Hironori Aramaki
Released: May 13, 2017
Abstract Full Text PDF[248K]
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Original Article
Repeated-dose ocular instillation toxicity study: a survey of its study design on the basis of common technical documents in Japan Vol.4, No.2, p.95-99
Masaaki Kurata , Yoshinori Yamagiwa , Yu Haranosono , Hideyuki Sakaki
Released: May 13, 2017
Abstract Full Text PDF[1M]
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Original Article
Retraction: Quantitative morphometric analysis of vimentin filaments in Sertoli cells of rats after in utero DBP exposure
[Notice] Editor's Announcement was published on June 6, 2023		 Vol.4, No.2, p.85-93
Eisuke Kume , Yuya Okayama , Mituru Sugiyama , Hiroyuki Takahashi , Tomoko Muto , Michael F. Wempe , Hiroshi Ikegami , Shin Wakui
Released: May 13, 2017
Abstract Full Text PDF[3M]
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Toxicomics Report
Urinary proteome profile of renal papillary necrosis in experimental model rats Vol.4, No.2, p.77-83
Daisuke Sasaki , Masashi Hiramoto , Masatoshi Yuri , Kenjiro Tsubota , Hikaru Mitori , Akira Moriguchi , Akira Unami , Gi-Wook Hwang , Akira Naganuma
Released: April 14, 2017
Abstract Full Text PDF[410K]
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Original Article
Safety assessment of a soluble dietary fiber, isomaltodextrin, enzymatically produced from starch Vol.4, No.2, p.57-75
Tsuyoshi Sadakiyo , Shin-ichiro Inoue , Yuki Ishida , Hikaru Watanabe , Hitoshi Mitsuzumi , Shimpei Ushio
Released: March 25, 2017
Abstract Full Text PDF[344K]
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Original Article
Oral acute and chronic toxicity studies of β, β-dimethylacrylalkannin in mice and rats Vol.4, No.2, p.45-56
Piao-Piao Zhang , Xiao-Dan Yan , Xiao-Yu Fan , Ya-Hao Ling , Chao Li , Lin Lin , Dan Qin , Tian-Tian Liu , Ye Li , Hui Li , Qianqian Zhang , Wen-Bo Mu , Ai-Ping Wang , Hong-Tao Jin , Jin-Feng Wei
Released: March 17, 2017
Abstract Full Text PDF[4M]
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Letter
Small interfering RNA-mediated knockdown of the transcription factor TCF3 enhances sensitivity to methylmercury in mouse neural stem cells Vol.4, No.2, p.41-43
Tsutomu Takahashi , Yanjiao Wang , Takashi Toyama , Min-Seok Kim , Shusuke Kuge , Gi-Wook Hwang , Akira Naganuma
Released: March 07, 2017
Abstract Full Text PDF[874K]
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Toxicomics Report
Identification of transcription factors activated by methylmercury in mouse brain Vol.4, No.1, p.37-39
Min-Soek Kim , Tsutomu Takahashi , Jin-Yong Lee , Nobuhiko Miura , Masato Asanuma , Gi-Wook Hwang , Akira Naganuma
Released: February 24, 2017
Abstract Full Text PDF[329K]
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Toxicomics Report
Proteomic analysis of valproic acid-induced embryotoxicity in cultured post-implantation rat embryos Vol.4, No.1, p.31-35
Makoto Usami , Mina Takamatsu , Shugo Kazama , Katsuyoshi Mitsunaga , Atsuko Miyajima , Tomohiko Irie , Osamu Doi , Tatsuya Takizawa , Teruko Nagi , Momoko Sunouchi
Released: February 24, 2017
Abstract Full Text PDF[1M]
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Original Article
Application of a portable gas chromatograph for quantitative measurement of canine oral malodor Vol.4, No.1, p.23-29
Naoki Iwashita , Kazutoshi Sugita , Mitsuyuki Shirai , Sayaka Murata , Shiho Yanagisawa , Sumio Goto , Yukihiko Takagi , Fumitoshi Asai
Released: February 24, 2017
Abstract Full Text PDF[521K]
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Original Article
Normal ovarian aging, but modified T-cell differentiation, in female mice following neonatal exposure to bisphenol A Vol.4, No.1, p.15-21
Ryo Ohta , Hideo Ohmukai , Tsukasa Negura , Yoshiyuki Tazura , Omoko Shindo
Released: February 17, 2017
Abstract Full Text PDF[1M]
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Letter
Effects of oral administration of gelatin capsules on plasma insulin and glucagon levels in dogs Vol.4, No.1, p.9-14
Hideaki Yokoyama , Taku Masuyama , Tomio Ishida , Yusuke Suzuki , Toshiyuki Shoda , Hideyuki Kuno , Shoichiro Sugai
Released: February 08, 2017
Abstract Full Text PDF[377K]
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Original Article
Simultaneous depletion of WRNIP1 and RAD52 restores resistance to oxidative stress Vol.4, No.1, p.1-7
Akari Yoshimura , Haruna Yabe , Miho Akatani , Masayuki Seki , Takemi Enomoto
Released: January 27, 2017
Abstract Full Text PDF[1M]
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2016 - Vol. 3

Original Article
Streptozotocin-induced diabetic state triggers glucose-dependent insulinotropic polypeptide (GIP) expression in the rat liver Vol.3, No.6, p.291-296
Yuka Kohda , Chiaki Minamigawa , Mikako Matsuo , Hitoshi Matsumura
Released: December 24, 2016
Abstract Full Text PDF[694K]
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Original Article
Sensitivity of MT-III null mice upon chronic exposure to cadmium Vol.3, No.6, p.285-289
Jin-Yong Lee , Maki Tokumoto , Yasuyuki Fujiwara , Gi-Wook Hwang , Moo-Yeol Lee , Masahiko Satoh
Released: December 21, 2016
Abstract Full Text PDF[892K]
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Letter
Cadmium-induced protein ubiquitination in UBA80 knockdown HK-2 cells Vol.3, No.6, p.281-284
Jin-Yong Lee , Maki Tokumoto , Gi-Wook Hwang , Masahiko Satoh
Released: November 26, 2016
Abstract Full Text PDF[634K]
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Letter
DNA microarray analysis of fetal liver of C57BL/6J mice exposed to cadmium during gestation Vol.3, No.6, p.257-280
Hisaka Kurita , Hisamitsu Nagase , Maki Tokumoto , Jin-Yong Lee , Masahiko Satoh
Released: November 26, 2016
Abstract Full Text PDF[232K]
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Original Article
Validation of retrospective evaluation method for false genotoxic chemicals with strong cytotoxicity: re-evaluation using in vitro micronucleus test Vol.3, No.6, p.251-256
Yurika Fujita , Yuichi Ito , Osamu Morita , Hiroshi Honda
Released: November 25, 2016
Abstract Full Text PDF[294K]
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Letter
Safety assessment of probiotic bacteria, Bacillus coagulans strain SANK70258, in rats Vol.3, No.6, p.243-250
Yui Akagawa , Yasuyuki Ohnishi , Masatoshi Takaya , Yuko Watanabe
Released: October 19, 2016
Abstract Full Text PDF[283K]
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Letter
Combined effect of circadian dysfunction and cadmium on immune suppression Vol.3, No.5, p.237-242
Katsumi Ohtani , Atsushige Ashimori , Yukie Yanagiba , Hiroki Yoshioka , Tatsuya Hasegawa , Gi-Wook Hwang , Masayuki Ikeda , Nobuhiko Miura
Released: October 04, 2016
Abstract Full Text PDF[344K]
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Letter
Hepatoprotective effect of kampo formula “Juzen-taiho-to” on bromobenzene-induced toxicity in mice Vol.3, No.5, p.233-236
Hiroki Yoshioka , Shiori Fukaya , Nobuhiko Miura , Akito Nagatsu , Tsunemasa Nonogaki
Released: September 10, 2016
Abstract Full Text PDF[278K]
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Minireview
Ocular instillation toxicity study: current status and points to consider on study design and evaluation Vol.3, No.5, p.217-232
Masaaki Kurata , Ikuyo Atsumi , Yoshinori Yamagiwa , Hideyuki Sakaki
Released: August 18, 2016
Abstract Full Text PDF[285K]
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Original Article
In vitro and in vivo toxicological assessments of Antrodia cinnamomea health food product (Leader Antrodia cinnamomea Capsule) Vol.3, No.5, p.205-216
Yu-Hsing Lin , K.J. Senthil Kumar , M. Gokila Vani , Jiunn-Wang Liao , Chin-Chung Lin , Jong-Tar Kuo , Sheng-Yang Wang
Released: August 02, 2016
Abstract Full Text PDF[234K]
Supplemental Data
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Original Article
Acute toxicity of phorate oxon by oral gavage in the Sprague-Dawley rat Vol.3, No.5, p.195-204
Thomas H. Snider , Kevin G. McGarry , Michael C. Babin , David A. Jett , Gennady E. Platoff Jr. , David T. Yeung
Released: July 22, 2016
Abstract Full Text PDF[4M]
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Original Article
Neurobehavioral toxicity related to the exposure of weaning mice to low-level mercury vapor and methylmercury and influence of aging Vol.3, No.4, p.185-193
Minoru Yoshida , Jin-Yong Lee , Hana Shimizu-Furusawa , Masahiko Satoh , Chiho Watanabe
Released: June 17, 2016
Abstract Full Text PDF[1M]
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Original Article
Estimation of occupational exposure to drugs during tablet crushing Vol.3, No.4, p.177-183
Shizuko Maeda , Eiko Takahashi , Yoshitaka Tayama , Shigeyuki Kitamura , Toyohisa Tsukamoto , Katsushi Miyake , Kazumi Sugihara
Released: June 15, 2016
Abstract Full Text PDF[873K]
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Original Article
The in vivo Pig-a gene mutation assay is applied to study the genotoxicity of procarbazine hydrochloride in Sprague-Dawley rats Vol.3, No.4, p.167-175
Jiang Pu , Yuanyuan Deng , Xiaoyan Tan , Gaofeng Chen , Cong Zhu , Naisong Qi , Hairuo Wen , Jun Guo , Xin Wang , Yuwen Qiu , Jinqiang Liang , Xinlu Fu , Yanping Hu , Jie Song , Xingchao Geng , Chao Wang , Lin Zhang , Zhiying Huang , Bo Li , Xue Wang
Released: May 31, 2016
Abstract Full Text PDF[2M]
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Original Article
A high-throughput Bhas 42 cell transformation assay for the determination of the carcinogenicity of three herbal extracts Vol.3, No.4, p.157-166
Jiang Pu , Ying Wang , Naisong Qi , Wenwan Du , Xiaoyan Tan , Gaofeng Chen , Hairuo Wen , Xin Wang , Yanping Hu , Jie Song , Yuwen Qiu , Jinqiang Liang , Xinlu Fu , Zhiying Huang , Xue Wang
Released: May 31, 2016
Abstract Full Text PDF[2M]
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Original Article
Zinc sulfate pretreatment prevents carbon tetrachloride-induced lethal toxicity through metallothionein-mediated suppression of lipid peroxidation in mice Vol.3, No.4, p.151-156
Hiroki Yoshioka , Satomi Onosaka
Released: May 24, 2016
Abstract Full Text PDF[351K]
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Original Article
Peroxisome proliferator activated receptor-mediated genotoxicity of perfluoroalkyl acids using human lymphoblastoid cells Vol.3, No.4, p.143-150
Maki Nakamura , Tomomi Takahashi , Takuya Izumi , Masanori Miura , Satomi Kawaguchi , Ayumi Yamamoto , Shuji Tsuda , Takanori Nakamura , Shuhei Tanaka , Naoto Shimizu , Yu F. Sasaki
Released: May 20, 2016
Abstract Full Text PDF[1M]
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Original Article
GCN5-deficiency remarkably enhances the sensitivity of B cells in response to 4-nitroquinoline 1-oxide Vol.3, No.3, p.137-142
Hidehiko Kikuchi , Futoshi Kuribayashi , Hitomi Mimuro , Shinobu Imajoh-Ohmi
Released: May 17, 2016
Abstract Full Text PDF[451K]
Supplemental Data
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Letter
Acute hepatotoxicity induced by quetiapine fumarate in larval zebrafish Vol.3, No.3, p.127-135
Jinfeng Liang , Wangdong Jin , Haibin Wei , Hongwen Li , Fei Jia , Jing Qian , Hongcui Liu , Yanfeng Huang , Chunqi Li , Li Zhou , Thomas Efferth
Released: May 11, 2016
Abstract Full Text PDF[2M]
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Letter
Methyl cinnamate increases cell vulnerability to oxidative stress induced by hydrogen peroxide in rat thymocytes Vol.3, No.3, p.121-125
Hiromitsu Tsuzuki , Shota Inoue , Daiki Kobayashi , Gantulga Uuganbaatar , Kaori Kanemaru , Kumio Yokoigawa , Yasuo Oyama
Released: May 11, 2016
Abstract Full Text PDF[1M]
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Letter
Possible involvement of FosB in (–)-xanthatin-mediated anti-proliferative effects in human cancer MDA-MB-231 cells Vol.3, No.3, p.115-119
Shuso Takeda , Shunsuke Okajima , Momoko Noguchi , Hiroko Miyoshi , Kuniyoshi Koyachi , Kenji Matsumoto , Mitsuru Shindo , Hironori Aramaki
Released: May 11, 2016
Abstract Full Text PDF[287K]
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Letter
Cytotoxicity of zinc, copper and rhodium complexes with 1,10-phenanthroline or 2,9-dimethyl-1,10-phenanthroline in cultured vascular endothelial cells Vol.3, No.3, p.109-113
Takato Hara , Hiroka Matsuzaki , Takehiro Nakamura , Eiko Yoshida , Takanori Ohkubo , Hiroki Maruyama , Chika Yamamoto , Shinichi Saito , Toshiyuki Kaji
Released: May 11, 2016
Abstract Full Text PDF[3M]
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Original Article
Major histocompatibility complex expression in a rotenone model of Parkinson’s disease in rats Vol.3, No.3, p.101-108
Masami Ishido , Eiko Shimaya
Released: April 20, 2016
Abstract Full Text PDF[2M]
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Letter
Requirements for human iPS cell-derived hepatocytes as an alternative to primary human hepatocytes for assessing absorption, distribution, metabolism, excretion and toxicity of pharmaceuticals Vol.3, No.3, p.89-99
Tetsuro Araki , Norihiko Iwazaki , Naoki Ishiguro , Atsushi Sakamoto , Keisuke Nagata , Masato Ohbuchi , Hiroyuki Moriguchi , Makiko Motoi , Raku Shinkyo , Toshiki Homma , Sakae Sakamoto , Yumiko Iwase , Ryota Ise , Yasuharu Nakanishi , Masahiro Uto , Tomoaki Inoue
Released: April 05, 2016
Abstract Full Text PDF[1M]
Supplemental Data
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Original Article
Comparative study of the zebrafish embryonic toxicity test and mouse embryonic stem cell test to screen developmental toxicity of human pharmaceutical drugs Vol.3, No.2, p.79-87
Atsuto Inoue , Yuhei Nishimura , Norihito Matsumoto , Noriko Umemoto , Yasuhito Shimada , Toru Maruyama , Kana Kayasuga , Motohiko Morihara , Jun Katagi , Tsutomu Shiroya , Yasushi Hirota , Soonih Kim , Toshio Tanaka
Released: March 26, 2016
Abstract Full Text PDF[2M]
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Toxicomics Report
Overexpression of palmitoyl transferase HIP14 confers resistance to methylmercury in SH-SY5Y human neuroblastoma cells Vol.3, No.2, p.75-77
Yousuke Ogiwara , Nobuhiko Miura , Shusuke Kuge , Akira Naganuma , Gi-Wook Hwang
Released: March 26, 2016
Abstract Full Text PDF[196K]
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Original Article
Prenatal exposure to rutile-type alumina-coated titanium dioxide nanoparticles impairs mouse spermatogenesis Vol.3, No.2, p.67-74
Miyoko Kubo-Irie , Yusuke Shinkai , Shotaro Matsuzawa , Hiroki Uchida , Kenichiro Suzuki , Rikio Niki , Shigeru Oshio , Ken Takeda
Released: March 17, 2016
Abstract Full Text PDF[4M]
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Toxicomics Report
Transcription factor activation in rat primary astrocytes exposed to methylmercury Vol.3, No.2, p.63-65
Takuya Takemoto , Yasuhiro Ishihara , Mayumi Tsuji , Toshihiro Kawamoto , Takeshi Yamazaki
Released: March 04, 2016
Abstract Full Text PDF[169K]
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Letter
HU-210, a synthetic analog of Δ9-THC, is not a modifier of estrogen signaling in MCF-7 human breast cancer cells Vol.3, No.2, p.55-61
Hiroyuki Okazaki , Shuso Takeda , Hiroyuki Ishii , Saki Matsuo , Erika Furuta , Kazuhito Watanabe , Hironori Aramaki
Released: March 03, 2016
Abstract Full Text PDF[389K]
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Letter
Differing responses of human stem cell-derived cardiomyocytes to arrhythmogenic drugs, determined using impedance measurements Vol.3, No.2, p.47-53
Arisa Higa , Hirotaka Hoshi , Motoki Takagi
Released: February 26, 2016
Abstract Full Text PDF[2M]
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Original Article
Toxicogenomic prediction with graph-based structured regularization on transcription factor network Vol.3, No.2, p.39-46
Keisuke Nagata , Yoshinobu Kawahara , Takashi Washio , Akira Unami
Released: February 26, 2016
Abstract Full Text PDF[888K]
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Letter
Fipronil, an insecticide, acts as an anti-estrogen via the concomitant down-regulation of ERα and PES1 Vol.3, No.1, p.33-37
Hiroyuki Okazaki , Eriko Kohro-Ikeda , Shuso Takeda , Hiroyuki Ishii , Erika Furuta , Saki Matsuo , Masaya Matsumoto , Masufumi Takiguchi , Hironori Aramaki
Released: February 23, 2016
Abstract Full Text PDF[295K]
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Letter
Quantitative analysis of the relationship between the LLNA:DAE method results and the LLNA EC3 values highlights the connection between the elicitation and induction phases during skin sensitization Vol.3, No.1, p.27-31
Kunihiko Yamashita , Shinsuke Shinoda , Saori Hagiwara , Hiroshi Itagaki
Released: February 03, 2016
Abstract Full Text PDF[232K]
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Original Article
A study on the influence of acotiamide hydrochloride hydrate on sex hormones, using a uterotrophic bioassay in rat Vol.3, No.1, p.19-25
Hiroyuki Kuroda , Takashi Yamaguchi , Toshiko Kinomoto , Shuji Ogawa , Hitoshi Naraoka , Kazuhiko Takamatsu , Yuji Oishi
Released: January 26, 2016
Abstract Full Text PDF[1M]
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Original Article
Hepatitis C virus core can induce lipid droplet formation in a yeast model system Vol.3, No.1, p.13-18
Shingo Iwasa , Naoko Satoh , Hayato Irokawa , Junichi Kikuchi , Jun Okawa , Masataka Nomoto , Gi-Wook Hwang , Akira Naganuma , Shusuke Kuge
Released: January 13, 2016
Abstract Full Text PDF[902K]
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Letter
Single dose oral toxicity study of Picrorhiza kurroa rhizome extract in Wistar rats Vol.3, No.1, p.9-12
Acharya Bal Krishna , Hemanth Kumar Manikyam , Vinay K Sharma , Niti Sharma
Released: January 13, 2016
Abstract Full Text PDF[226K]
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Letter
Physiological conditions in iPRECIO® -implanted rats Vol.3, No.1, p.1-8
Masaru Tsuboi , Yoshihide Ueda , Yasufumi Ota , Hiroshi Takehara , Takuya Aoshima , Fukutaro Mizuhashi
Released: January 09, 2016
Abstract Full Text PDF[471K]
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2015 - Vol. 2

Toxicomics Report
The enhancement effect of HIST1H4C knockdown on cadmium toxicity in human proximal tubular cells Vol.2, No.6, p.259-262
Jin-Yong Lee , Maki Tokumoto , Masahiko Satoh
Released: December 22, 2015
Abstract Full Text PDF[274K]
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Original Article
Developmental changes in associative learning behavior in male rats Vol.2, No.6, p.249-258
Rieko Hojo , Yukie Yanagiba , Megumi Suda , Masao Tsuchiya
Released: December 22, 2015
Abstract Full Text PDF[380K]
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Toxicomics Report
Knockdown of Acyl-CoA thioesterase 9 gene expression by siRNA confers resistance to arsenite in HEK293 cells Vol.2, No.6, p.245-247
Tsutomu Takahashi , Min-Seok Kim , Gi-Wook Hwang , Shusuke Kuge , Akira Naganuma
Released: December 21, 2015
Abstract Full Text PDF[295K]
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Letter
Methylmercury induces expression of interleukin-1β and interleukin-19 in mice brains Vol.2, No.6, p.239-243
Tsutomu Takahashi , Miyuki Iwai-Shimada , Yukina Syakushi , Min-Seok Kim , Gi-Wook Hwang , Nobuhiko Miura , Akira Naganuma
Released: December 21, 2015
Abstract Full Text PDF[471K]
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Letter
(–)-Xanthatin-mediated marked up-regulation of RhoB, a sensor for damaged DNA Vol.2, No.6, p.233-238
Shuso Takeda , Shunsuke Okajima , Hiroko Miyoshi , Kuniyoshi Koyachi , Kenji Matsumoto , Mitsuru Shindo , Hironori Aramaki
Released: December 12, 2015
Abstract Full Text PDF[396K]
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Letter
Citrulline enhances methylmercury toxicity in HEK293 and C17.2 cells Vol.2, No.6, p.229-231
Takashi Toyama , Gi-Wook Hwang , Akira Naganuma
Released: December 11, 2015
Abstract Full Text PDF[530K]
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Toxicomics Report
Metabolomic analysis of low molecular weight substances released into medium from HEK293 cells treated with methylmercury Vol.2, No.5, p.227-228
Takashi Toyama , Gi-Wook Hwang , Akira Naganuma
Released: December 09, 2015
Abstract Full Text PDF[158K]
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Original Article
Methylmercury induces release of a cytotoxic factor from HEK293 cells into medium Vol.2, No.5, p.223-226
Takashi Toyama , Souichi Murakami , Shusuke Kuge , Gi-Wook Hwang , Akira Naganuma
Released: December 02, 2015
Abstract Full Text PDF[988K]
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Letter
Cytotoxic actions of N-(2,4,6-trichlorophenyl)maleimide (IT-354), an antifouling agent, in rat thymic lymphocytes Vol.2, No.5, p.217-222
Eri Fukunaga , Shohei Saito , Yuya Kurumi , Yurie Ohiwa , Eri Kurozumi , Yasuo Oyama
Released: November 26, 2015
Abstract Full Text PDF[1M]
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Original Article
Zn2+-dependent increase in cells with phosphatidylserine-exposed membranes after treatment with submicromolar concentrations of 2-n-octyl-4-isothiazolin-3-one in rat thymocytes Vol.2, No.5, p.209-216
Eri Fukunaga , Sari Honda , Yuji Hashimoto , Yasuaki Tamura , Shiro Ishida , Yasuo Oyama
Released: November 16, 2015
Abstract Full Text PDF[1M]
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Original Article
Bioconcentration of perfluorinated compounds in wild medaka is related to octanol/water partition coefficient Vol.2, No.5, p.201-208
Katsumi Iwabuchi , Norimasa Senzaki , Shuji Tsuda , Haruna Watanabe , Ikumi Tamura , Hitomi Takanobu , Norihisa Tatarazako
Released: October 27, 2015
Abstract Full Text PDF[673K]
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Original Article
A repeated dose 28-day oral toxicity study of β-bromostyrene in rats Vol.2, No.4, p.191-200
Atsushi Ono , Katsumi Kobayashi , Hideki Serizawa , Tomoko Kawamura , Hina Kato , Mariko Matsumoto , Mika Takahashi , Mutsuko Hirata-Koizumi , Yuko Matsushima , Akihiko Hirose
Released: September 29, 2015
Abstract Full Text PDF[202K]
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Original Article
Repeated dose and reproductive/developmental toxicity of long-chain perfluoroalkyl carboxylic acids in rats: perfluorohexadecanoic acid and perfluorotetradecanoic acid Vol.2, No.4, p.177-190
Mutsuko Hirata-Koizumi , Sakiko Fujii , Kato Hina , Mariko Matsumoto , Mika Takahashi , Atsushi Ono , Akihiko Hirose
Released: September 28, 2015
Abstract Full Text PDF[369K]
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Letter
Health survey of workers in a 2,4,6-trinitrotoluene explosives factory in Fuxin, China Vol.2, No.4, p.171-175
Yasuhiro Shinkai , Song Li , Tomohiro Kikuchi , Nobuhiro Shimojo , Yoshito Kumagai
Released: September 15, 2015
Abstract Full Text PDF[172K]
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Original Article
Toxicogenomic prediction with group sparse regularization based on transcription factor network information Vol.2, No.4, p.161-170
Keisuke Nagata , Yoshinobu Kawahara , Takashi Washio , Akira Unami
Released: September 15, 2015
Abstract Full Text PDF[1M]
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Letter
Effects of rofecoxib on lipid oxidation in plasma and aortas of rats Vol.2, No.4, p.155-159
Atsushi Miyajima , Yasuha Amano , Takeyoshi Kamamoto , Masahiro Okamoto , Takashi Hirota
Released: September 07, 2015
Abstract Full Text PDF[243K]
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Letter
In vitro comet assay in cultured human corneal epithelial cells Vol.2, No.4, p.147-153
Hideyuki Sakaki , Masaki Kakehi , Kazuyo Sadamoto , Shingo Nemoto , Masaaki Kurata
Released: September 04, 2015
Abstract Full Text PDF[1M]
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Original Article
Effects of cisplatin on testicular enzymes and Sertoli cell function in rats Vol.2, No.4, p.137-145
Zhifei Liu , Yingbiao Sun , Li Su , Yifan Sun , Shibo Kong , Xuhong Chang , Fang Guo , Wei Li , Junjie Guo , Jin Li
Released: August 25, 2015
Abstract Full Text PDF[1M]
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Original Article
Effects of dietary fish oil on cytochrome P450 3A expression in the liver of SHR/NDmcr-cp (cp/cp) rats, an animal model for metabolic syndrome Vol.2, No.3, p.127-135
Tohru Yamazaki , Takashi Ohki , Hiroki Taguchi , Asami Yamamoto , Mari Okazaki , Takeshi Sakamoto , Atsushi Mitsumoto , Yoichi Kawashima , Naomi Kudo
Released: August 05, 2015
Abstract Full Text PDF[347K]
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Original Article
The concern for uterine carcinogenesis in safety assessments for a new pharmaceutical Vol.2, No.3, p.117-126
Hiroyuki Kuroda , Takashi Yamaguchi , Toshiko Kinomoto , Shuji Ogawa , Atsushi Shiga , Hitoshi Naraoka , Kazuhiko Takamatsu , Yuji Oishi
Released: July 30, 2015
Abstract Full Text PDF[2M]
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Letter
Evaluation of laser irradiance on photodynamic therapy using talaporfin sodium-induced glioblastoma T98G cell death Vol.2, No.3, p.111-116
Yuichi Miki , Jiro Akimoto , Aya Sato , Yasuyuki Fujiwara
Released: June 26, 2015
Abstract Full Text PDF[2M]
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Letter
Positive and negative ions by air purifier have no effects on reproductive function or postnatal growth and development in rats Vol.2, No.3, p.101-110
Dai Yamamoto , Yumi Wako , Shino Kumabe , Kiyoshi Wako , Yukari Sato , Mayumi Fujishiro , Yoshimasa Yasuda , Ikuo Matsuura , Yasuyuki Ohnishi
Released: June 23, 2015
Abstract Full Text PDF[181K]
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Original Article
Metabolism of trimethylselenonium ion in selenium accumulator, Allium sativum Vol.2, No.3, p.95-99
Yasumitsu Ogra , Yurie Ogihara , Yasumi Anan
Released: June 16, 2015
Abstract Full Text PDF[379K]
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Toxicomics Report
DNA microarray analysis of genes in highly metastatic 4T1E/M3 murine breast cancer cells following exposure to cannabidiolic acid Vol.2, No.2, p.89-94
Shuso Takeda , Hiroyuki Okazaki , Eriko Kohro-Ikeda , Kazutaka Yoshida , Miki Tokuyasu , Yukimi Takemoto , Ramu Mizunoe , Sawa Tanaka , Tomoko Okada , Hironori Aramaki
Released: June 01, 2015
Abstract Full Text PDF[524K]
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Original Article
Measurement of oral bacterial counts in dogs by dielectrophoretic impedance Vol.2, No.2, p.83-87
Soraaki Takahashi , Motoi Kuratani , Maho Tanaka , Tetsuro Ito , Nobuyuki Kanemaki , Mitsuyuki Shirai , Ryota Nomura , Kazuhiko Nakano , Fumitoshi Asai
Released: May 27, 2015
Abstract Full Text PDF[221K]
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Letter
Motor activities of newborns prenatally exposed to low-dose bisphenol A in diverse mouse strains Vol.2, No.2, p.79-82
Nao Kagawa , Munekazu Komada , Tetsuji Nagao
Released: May 27, 2015
Abstract Full Text PDF[238K]
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Original Article
Effect of prenatal methylmercury exposure on neurobehavioral development in male mice: comparison between methylmercury in fish and methylmercury chloride added to diets Vol.2, No.2, p.67-78
Miyuki Iwai-Shimada , Michiaki Yamashita , Naoyuki Kurokawa , Kunihiko Nakai , Mitsuharu Ishida , Akira Naganuma , Hiroshi Satoh
Released: April 03, 2015
Abstract Full Text PDF[481K]
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Letter
Comparative cytotoxicity of triphenylstibane and fluorine-substituted triarylpnictogens in cultured vascular endothelial cells Vol.2, No.2, p.61-66
Masaki Murakami , Tomoya Fujie , Mio Matsumura , Eiko Yoshida , Chika Yamamoto , Yasuyuki Fujiwara , Shuji Yasuike , Toshiyuki Kaji
Released: March 28, 2015
Abstract Full Text PDF[1M]
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Original Article
Metabolic fate of excessive glucose in fibroblast cells in a diabetic setting Vol.2, No.2, p.55-60
Yuka Kohda , Kazuma Iwatate , Takao Tanaka , Hitoshi Matsumura
Released: February 20, 2015
Abstract Full Text PDF[327K]
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Letter
Comparison of cytotoxicity among pectenotoxin-2 and other oxidized pectenotoxins in a rat myoblast cell line (L6) and a human rhabdomyosarcoma cell line (RD) Vol.2, No.1, p.49-54
Ryoji Matsushima , Saori Kikutsugi , Ryuichi Watanabe , Hajime Uchida , Takeshi Yasumoto , Hiroshi Nagai , Masaki Kaneniwa , Toshiyuki Suzuki
Released: February 03, 2015
Abstract Full Text PDF[1M]
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Original Article
Utility of human hepatocyte spheroids for evaluation of hepatotoxicity Vol.2, No.1, p.41-48
Takuo Ogihara , Hisakazu Iwai , Yukiko Inoue , Jun Katagi , Norihito Matsumoto , Makiko Motoi-Ohtsuji , Motoharu Kakiki , Shinya Kaneda , Takuya Nagao , Kumiko Kusumoto , Emiko Ozeki , Tomoko Jomura , Sho Tanaka , Tadayoshi Ueda , Kunihiro Ohta , Takako Ohkura , Hiroshi Arakawa , Daichi Nagai
Released: January 21, 2015
Abstract Full Text PDF[489K]
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Letter
Effects of prenatal exposure to low doses of diethylstilbestrol on motor activity in newborn mice Vol.2, No.1, p.37-39
Kaho Ozaki , Nao Kagawa , Munekazu Komada , Tetsuji Nagao
Released: January 16, 2015
Abstract Full Text PDF[200K]
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Original Article
Impact of different blood sampling techniques on plasma biomarkers for skeletal myopathy in conscious rats Vol.2, No.1, p.25-36
Kyoko Miwa , Satoshi Tamai , Yasuhiro Kinpara , Satomi Komatsu , Mayumi Goto , Takuma Iguchi , Takami Suzuki , Wataru Takasaki , Kazuhiko Mori
Released: January 16, 2015
Abstract Full Text PDF[955K]
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Letter
Silica nanoparticle-induced toxicity in mouse lung and liver imaged by electron microscopy Vol.2, No.1, p.19-23
Katsuhiro Isoda , Masuo Kondoh , Yasuo Yoshioka , Yasuo Tsutsumi , Takayoshi Imazawa , Tetsuji Nishimura , Isao Ishida , Kiyohito Yagi
Released: January 16, 2015
Abstract Full Text PDF[3M]
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Original Article
Effects of sub-chronic exposure to deltamethrin on shuttle-box avoidance and contents of amino acid neurotransmitters in hippocampus of mice Vol.2, No.1, p.9-17
Cao Pei , Ma Ning , Gao Peng , Feng Yong-quan , Wang Xiao-dan , Xu Hai-bin
Released: January 13, 2015
Abstract Full Text PDF[1M]
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Original Article
Effect of nanoparticles injected into larvae on spermatogenesis in the pupal testis of the sweet potato hornworm, Agrius convolvuli (L.) Vol.2, No.1, p.1-8
Miyoko Kubo-Irie , Masami Shimoda , Azumi Sato , Kyhota Shida , Terumi Yamaguchi , Hideo Mohri , Ken Takeda , Masaru Irie
Released: January 13, 2015
Abstract Full Text PDF[3M]
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2014 - Vol. 1

Letter
Estimation of endoplasmic reticulum stress-inducing ability of nobiletin, a citrus polymethoxyflavonoid, in SK-N-SH human neuroblastoma cells Vol.1, No.4, p.169-172
Ayaka Ikeda , Shingo Miyata , Akihito Yokosuka , Yoshihiro Mimaki , Yasushi Ohizumi , Masakuni Degawa , Kiyomitsu Nemoto
Released: December 25, 2014
Abstract Full Text PDF[363K]
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Toxicomics Report
The involvement of GPRC5B in cadmium toxicity in HK-2 cells Vol.1, No.4, p.165-167
Jin-Yong Lee , Maki Tokumoto , Yasuyuki Fujiwara , Moo-Yeol Lee , Masahiko Satoh
Released: December 25, 2014
Abstract Full Text PDF[754K]
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Toxicomics Report
CDC23 knockdown reinforces methylmercury sensitivity in HEK293 cells Vol.1, No.4, p.161-164
Ke Du , Tsutomu Takahashi , Miyuki Iwai-Shimada , Nobuhiko Miura , Akira Naganuma , Gi-Wook Hwang
Released: December 24, 2014
Abstract Full Text PDF[1M]
Page Top
Original Article
Safety evaluation of mutagenecity, acute and subacute toxicity study of Chlorella vulgaris CK-22 in rats Vol.1, No.4, p.151-159
Sayaka Himuro , Sugi Ueno , Naoto Noguchi , Takuya Uchikawa , Koji Watanabe
Released: December 22, 2014
Abstract Full Text PDF[333K]
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Original Article
Apoptotic activities of the extract from Moringa oleifera leaves on human HCT116 colon cancer cells Vol.1, No.4, p.143-149
Jintana Tragulpakseerojn , Ryuzaburo Yuki , Takuya Honda , Mariko Morii , Auayporn Apirakaramwong , Noritaka Yamaguchi , Perayot Pamonsinlapatham , Naoto Yamaguchi
Released: December 16, 2014
Abstract Full Text PDF[664K]
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Letter
Effects of a repeated low dose of LiCl injection under conditioned taste/flavor aversion using xylene Vol.1, No.4, p.135-142
Rieko Hojo , Mitsutoshi Takaya , Yukie Yanagiba , Akinori Yasuda , Masao Tsuchiya , Yasutaka Ogawa
Released: December 08, 2014
Abstract Full Text PDF[276K]
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Toxicomics Report
Effects of cadmium on the gene expression of SLC39A1 coding for ZIP1 protein Vol.1, No.4, p.131-133
Jin-Yong Lee , Maki Tokumoto , Yasuyuki Fujiwara , Moo-Yeol Lee , Masahiko Satoh
Released: December 04, 2014
Abstract Full Text PDF[413K]
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Original Article
The paradoxical effect of 1,4-naphthoquinone on the process of cell death induced by hydrogen peroxide in rat thymocytes Vol.1, No.4, p.123-129
Hana Ohtani , Eri Fukunaga , Yasuo Oyama , Shiro Ishida , Norio Akaike
Released: November 21, 2014
Abstract Full Text PDF[937K]
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Original Article
Diallyl disulfide administration increases the number of B-lymphocytes in the rat spleen Vol.1, No.4, p.115-121
Yoko Hashizume , Ken Shirato , Kaoru Tachiyashiki , Kazuhiko Imaizumi
Released: November 19, 2014
Abstract Full Text PDF[395K]
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Toxicomics Report
Identification of growth-dependent genes involved in paraquat toxicity in Saccharomyces cerevisiae Vol.1, No.3, p.113-114
Tsutomu Takahashi , JunXuan Zhu , Naoya Sonoda , Shusuke Kuge , Gi-Wook Hwang , Akira Naganuma
Released: November 10, 2014
Abstract Full Text PDF[379K]
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Toxicomics Report
Overexpression of RPN8, SKP1, MIA40 or MES1 increases resistance to cadmium in Saccharomyces cerevisiae Vol.1, No.3, p.109-111
Tsutomu Takahashi , JunXuan Zhu , Shusuke Kuge , Gi-Wook Hwang , Akira Naganuma
Released: November 10, 2014
Abstract Full Text PDF[301K]
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Original Article
Sex-dependent difference in the hepatic and pulmonary toxicological effects in mice administrated 7-chlorinated benz[a]anthracene Vol.1, No.3, p.101-108
Hiroyuki Sakakibara , Takashi Ohura , Yuta Kamiya , Noriko Yamanaka , Nobuaki Shimada , Kayoko Shimoi , Keerthi S. Guruge
Released: November 10, 2014
Abstract Full Text PDF[288K]
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Original Article
A screening method for growth-dependent genes involved in the cytotoxicity of chemicals in Saccharomyces cerevisiae Vol.1, No.3, p.95-99
JunXuan Zhu , Tsutomu Takahashi , Shusuke Kuge , Gi-Wook Hwang , Akira Naganuma
Released: November 06, 2014
Abstract Full Text PDF[387K]
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Original Article
Residual metals in carbon nanotubes suppress the proliferation of neural stem cells Vol.1, No.3, p.87-94
Yukari Shigemoto-Mogami , Koki Fujimori , Yoshiaki Ikarashi , Akihiko Hirose , Yuko Sekino , Kaoru Sato
Released: November 06, 2014
Abstract Full Text PDF[236K]
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Letter
Hazardous effects of titanium dioxide nanoparticles on testicular function in mice Vol.1, No.3, p.81-85
Nobuhiko Miura , Katsumi Ohtani , Tatsuya Hasegawa , Rieko Hojo , Yukie Yanagiba , Tetsuya Suzuki , Megumi Suda , Rui-Sheng Wang
Released: October 28, 2014
Abstract Full Text PDF[218K]
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Original Article
Effects of organic and inorganic mercury(II) on gene expression via DNA conformational changes Vol.1, No.2, p.73-79
Koji Ueda , Rena Makino , Takao Tobe , Yoshinori Okamoto , Nakao Kojima
Released: October 23, 2014
Abstract Full Text PDF[593K]
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Original Article
A 4-week oral toxicity study of L-alanine in rats with a recovery period of 2 weeks Vol.1, No.2, p.63-72
Mami Aoki , Masahiro Mochizuki , Toshiya Okamura , Kazuhisa Hatayama , Atsushi Nakamura , Koji Morishita
Released: October 23, 2014
Abstract Full Text PDF[206K]
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Original Article
A 13-week feeding toxicity study of L-threonine in rats with a recovery period of 5 weeks Vol.1, No.2, p.49-62
Mami Aoki , Shigeru Ishida , Hideki Fukuzumi , Koji Morishita
Released: October 23, 2014
Abstract Full Text PDF[104K]
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Original Article
Safety evaluation of morphological changes in corneal endothelial cells induced by K-115 in cynomolgus monkeys Vol.1, No.2, p.39-47
Eiji Wato , Kozo Omichi , Shigeki Yoneyama , Mamoru Tanaka , Masataka Kagawa , Yukinori Amano
Released: October 15, 2014
Abstract Full Text PDF[416K]
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Original Article
28-Day dietary toxicity study of L-phenylalanine in rats Vol.1, No.2, p.29-38
Yusuke Shibui , Tadashi Miwa , Terutaka Kodama , Akinori Gonsho
Released: September 27, 2014
Abstract Full Text PDF[100K]
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Original Article
Nonclinical safety assessment for the sensitizing potential of K-115 Vol.1, No.1, p.19-27
Kozo Omichi , Eiji Wato , Yoshiki Kaneko , Shigeki Yoneyama , Akitaka Matsuda , Mikio Sasaki , Adrian Bull , David Coleman , Masataka Kagawa , Yukinori Amano
Released: September 04, 2014
Abstract Full Text PDF[109K]
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Original Article
Cytotoxic activity and abdominal writhes promoted by snake venom from Philodryas nattereri Steindachner, 1870 Vol.1, No.1, p.15-18
Marinetes Dantas de Aquino Nery , Hermano Damasceno de Aquino , Rayane de Tasso Moreira Ribeiro , Erik de Aquino Nery , Thiala Soares Josino da Silva , Rodrigo Tavares Dantas , Ramon Róseo Paula Pessoa Bezerra de Menezes , Marcus Felipe Bezerra da Costa , Alice Maria Costa Martins , Natacha Teresa Queiroz Alves , Helena Serra Azul Monteiro
Released: September 04, 2014
Abstract Full Text PDF[115K]
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Original Article
Edematogenic and myotoxic activities induced by snake venom of Philodryas nattereri from the Northeast of Brazil Vol.1, No.1, p.7-13
Marinetes Dantas de Aquino Nery , Hermano Damasceno de Aquino , Rayane de Tasso Moreira Ribeiro , Erik de Aquino Nery , Dalgimar Beserra de Menezes , Rafael Matos Ximenes , Arislete Dantas de Aquino , Lia Belchior Mendes Bezerra , Natacha Teresa Queiroz Alves , Helena Serra Azul Monteiro
Released: September 04, 2014
Abstract Full Text PDF[1M]
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Letter
Investigation of organ-specific assessment factors related to sub-acute and sub-chronic toxicity studies Vol.1, No.1, p.1-6
Jun-ichi Takeshita , Atsuo Kishimoto , Masashi Gamo
Released: August 06, 2014
Abstract Full Text PDF[95K]
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