Fundamental Toxicological Sciences

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2024 - Vol. 11

Original Article
Application of the matrix profile algorithm for detecting abnormalities in rat electrocardiograms Vol.11, No.6, p.289-296
Yuhji Taquahashi , Ken-ich Aisaki , Koichi Morita , Kousuke Suga , Satoshi Kitajima
Released: December 11, 2024
Abstract Full Text PDF[3M]
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Original Article
Constructing a graph neural network-based artificial intelligence model to predict drug-induced phospholipidosis potential Vol.11, No.6, p.279-288
Yoshinobu Igarashi , Aki Hasegawa , Shigeyuki Matsumoto , Hiroaki Iwata , Ryosuke Kojima , Yasushi Okuno , Hiroshi Yamada
Released: November 22, 2024
Abstract Full Text PDF[1M]
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Original Article
Derivation of human health hazard assessment values for tetramethylammonium hydroxide (TMAH) under the Japan Chemical Substances Control Law Vol.11, No.6, p.267-278
Akira Kawashima , Kaoru Inoue , Kazuo Ushida , Kaoru Kai , Lucia Satiko Yoshida-Yamashita , Kenichi Masumura
Released: November 08, 2024
Abstract Full Text PDF[559K]
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Original Article
Relationship between the dose of intravenous self-administration and the minimum effective dose for gross behavioral effects in rhesus monkeys: opiates vs CNS depressants Vol.11, No.5, p.259-266
Kenshi Nakagawa , Atsushi Fujiwara , Masahiko Iino , Mikio Sasaki , Takahiro Ootsuka , Shin-ich Sato , Takayuki Anzai , Takaaki Matsuyama
Released: October 29, 2024
Abstract Full Text PDF[1M]
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Data Report
Estimation of daily cadmium intake in the United States through food analysis in 1980 Vol.11, No.5, p.251-257
Katsue Suzuki-Inoue , Seiichiro Himeno , Shosuke Suzuki
Released: October 23, 2024
Abstract Full Text PDF[781K]
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Original Article
Puberulic acid displays remarkable cytotoxicity and strong inhibitory effect on the all-trans retinoic acid-induced superoxide-generating ability in U937 cells Vol.11, No.5, p.243-249
Hidehiko Kikuchi , Kaori Harata , Takefumi Sagara , Harishkumar Madhyastha , Hitomi Mimuro , Futoshi Kuribayashi
Released: October 18, 2024
Abstract Full Text PDF[1007K]
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Letter
Hinokitiol and pyrrolidone carboxylate zinc or corn oligosaccharides: A Synergistic approach to combating scalp microorganisms in seborrheic dermatitis Vol.11, No.5, p.233-241
Akihiro Michihara , Hiroshi Matsuoka , Junichi Fujii , Chiharu Furukawa , Xianting Lin , Jianzhong Yang
Released: September 19, 2024
Abstract Full Text PDF[1M]
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Original Article
Safety evaluation of exomaltotetraohydrolase from Pseudomonas stutzeri Vol.11, No.5, p.215-231
Shuji Matsumoto , Alan B. Richards
Released: September 10, 2024
Abstract Full Text PDF[853K]
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Original Article
Zrt- and Irt-like protein 8 (ZIP8) and metallothionein aid in zinc protection of cultured vascular endothelial cells against cadmium cytotoxicity Vol.11, No.4, p.205-213
Tomoya Fujie , Akane Uehara , Keisuke Ito , Takato Hara , Chika Yamamoto , Toshiyuki Kaji
Released: August 22, 2024
Abstract Full Text PDF[1M]
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Original Article
Aristolochic acid C displays cytotoxic effect and remarkable enhancing effect on the all-trans retinoic acid-induced superoxide-generating ability in U937 cells Vol.11, No.4, p.197-204
Hidehiko Kikuchi , Kaori Harata , Harishkumar Madhyastha , Hitomi Mimuro , Futoshi Kuribayashi
Released: August 06, 2024
Abstract Full Text PDF[1M]
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Original Article
Safety evaluation of tomatidine-rich tomato leaf extract in mice and bacteria Vol.11, No.4, p.183-196
Taiken Sakano , Takanori Suzuki , Kenichiro Sato , Nobuya Yanai , Shigenobu Shiotani
Released: August 01, 2024
Abstract Full Text PDF[936K]
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Data Report
A 90-day repeated oral dose toxicity study of p-cymene in rats Vol.11, No.4, p.169-181
Makiko Kuwagata , Yuko Doi , Hirokatsu Saito , Mariko Tsurumoto , Toshime Igarashi , Takuya Nishimura , Yuhji Taquahashi , Yoko Hirabayashi , Satoshi Kitajima
Released: July 09, 2024
Abstract Full Text PDF[1M]
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Original Article
Utility of urinary N-titin as a muscle atrophy biomarker in dexamethasone-induced muscle atrophy model mice Vol.11, No.4, p.159-168
Katsunori Ryoke , Kana Ishizuka , Yuzo Yasui , Kazuma Kondo , Noriko Suzuki-Kemuriyama , Tatsuya Maekawa , Katsuhiro Miyajima
Released: July 02, 2024
Abstract Full Text PDF[2M]
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Original Article
Evaluation of pharmaceutical concentrations and antimicrobial activity in river water from the Tone River system in Gunma Prefecture, Japan Vol.11, No.4, p.149-157
Tsuyoshi Murahashi , Jun-ichi Yamagishi , Taiju Igarashi , Mako Kawai , Seiji Yamasaki , Kunihiko Nishino , Toshiyuki Higuchi
Released: July 02, 2024
Abstract Full Text PDF[1M]
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Letter
Collection of background data for repeated dose toxicity studies by intratracheal instillation in rats Vol.11, No.3, p.141-147
Kiyoshi Wako , Mitsutoshi Uchida , Keisuke Hotta , Jun Sasaki , Masanori Hoshino , Dai Yamamoto
Released: June 28, 2024
Abstract Full Text PDF[2M]
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Toxicomics Report
Alteration of gene levels in fetal brain by prenatal exposure to methylmercury, copper, and their combination Vol.11, No.3, p.131-139
Kensuke Sato , Ryota Nakano , Yoshitaka Yamazaki , Hikaru Isobe , Yun-Gi Kim , Masahiro Hosonuma , Masahiro Akiyama , Yoshito Kumagai
Released: June 19, 2024
Abstract Full Text PDF[1M]
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Minireview
Understanding the effects of food restriction on toxicological parameters: A comparative analysis in rats, dogs, and monkeys Vol.11, No.3, p.123-130
Nozomi Fujisawa
Released: June 19, 2024
Abstract Full Text PDF[763K]
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Original Article
Effect of differently coated titanium dioxide nanoparticles on the lung in wild-type and Nrf2 null mice Vol.11, No.3, p.109-121
Ryoya Takizawa , Akihiko Ikegami , Cai Zong , Syun Nemoto , Yuki Kitamura , Nathan Mise , Gaku Ichihara , Sahoko Ichihara
Released: June 11, 2024
Abstract Full Text PDF[1M]
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Original Article
The health risk assessment of mercury in rice from paddy fields around Nam Son landfill, Hanoi, Vietnam Vol.11, No.3, p.99-108
Nguyen Thi Quynh , Huiho Jeong , Ahmed Elwaleed , Yasuhiro Ishibashi , Koji Arizono
Released: June 11, 2024
Abstract Full Text PDF[2M]
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Original Article
Glial differentiation of mouse embryonic-stem-cell-derived neuronal precursors is a sensitive marker for assessing developmental neurotoxicity of insecticides Vol.11, No.3, p.87-98
Tomohiro Ito , Xian-Yang Qin , Yoshika Kurokawa , Yang Zeng , Satoshi Otsuka , Wenlong Wang , Hideko Sone
Released: June 11, 2024
Abstract Full Text PDF[2M]
Supplemental Data
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Original Article
Activation of Akt–cAMP response element-binding protein (CREB) signaling as an adaptive response to an electrophilic metabolite of morphine Vol.11, No.2, p.79-85
Kohei Matsuo , Shigeru Yamano , Akira Toriba , Kimihiko Matsusue , Yoshito Kumagai , Yumi Abiko
Released: May 21, 2024
Abstract Full Text PDF[1M]
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Letter
Investigation of solvents that can be used as vehicles to evaluate poorly soluble compounds in short-term oral toxicity studies in rats Vol.11, No.2, p.69-78
Keigo Ikeda , Mami Kochi , Tomoaki Tochitani , Naohisa Umeya , Izumi Matsumoto , Yuta Fujii , Toru Usui , Izuru Miyawaki
Released: May 14, 2024
Abstract Full Text PDF[2M]
Supplemental Data
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Original Article
Effects of food restriction for 3 or 7 days on toxicity-related parameters in rats Vol.11, No.2, p.57-67
Naohisa Umeya , Kumiyo Okada , Naoe Nishimura , Izumi Matsumoto , Toru Usui , Izuru Miyawaki
Released: April 09, 2024
Abstract Full Text PDF[4M]
Supplemental Data
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Original Article
Extracellular vesicle small RNAs secreted from mouse amniotic fluid induced by repeated oral administration of VPA to pregnant mice Vol.11, No.1, p.37-56
Ryuichi Ono , Makiko Kuwagata , Mie Naruse , Akihito Watanabe , Masao Takano , Takuro Hasegawa , Hiromasa Takashima , Yusuke Yoshioka , Takahiro Ochiya , Yoko Hirabayashi , Satoshi Kitajima
Released: March 22, 2024
Abstract Full Text PDF[3M]
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Original Article
Development of an in vivo pain assessment method for exposure to intermediate-frequency magnetic fields Vol.11, No.1, p.27-35
Shin Ohtani , Akira Ushiyama , Wasoontarajaroen Siriwat , Keiji Wada , Yukihisa Suzuki , Kenji Hattori
Released: March 19, 2024
Abstract Full Text PDF[2M]
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Original Article
Comparative analysis of bile canaliculi formation in fresh and flask-delivered human hepatocytes from humanized mouse livers under sufficient oxygen supply Vol.11, No.1, p.17-25
Fumiya Tokito , Ya Gong , Dhimas Agung Kurniawan , Shohei Kaneko , Hiroki Shioda , Sangho Lee , Atsuhito Kushima , Mutsumi Inamatsu , Chise Tateno , Hyunjin Choi , Masaki Nishikawa , Yasuyuki Sakai
Released: February 21, 2024
Abstract Full Text PDF[3M]
Supplemental Data
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Toxicomics Report
Indeterminate alteration of TRPM8 and p21/Cip1 levels in normal human keratinocytes by incubating with medium including substances released by squamous carcinoma cells Vol.11, No.1, p.11-15
Tomofumi Fujino , Saki Ohkawa
Released: February 09, 2024
Abstract Full Text PDF[1M]
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Original Article
Repeated dose administration toxicity studies - Use of t-tests in multiplicity data analysis Vol.11, No.1, p.1-10
Katsumi Kobayashi , Kalathil Sadasivan Pillai
Released: January 24, 2024
Abstract Full Text PDF[806K]
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2023 - Vol. 10

Letter
Inhibitory effect of mozuku seaweed-derived ultra-high-molecular-weight fucoidan on the growth of indigenous skin bacteria Vol.10, No.8, p.325-333
Hiroshi Matsuoka , Junichi Fujii , Yuka Nagatsuka , Masaya Ohta , Takashi Sugimoto , Yuhki Sato , Akihiro Michihara
Released: December 27, 2023
Abstract Full Text PDF[1M]
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Original Article
Flunitrazepam alters the toxicokinetics of chlorpromazine enhancing its toxicity Vol.10, No.8, p.315-323
Kota Nakajima , Asuka Kaizaki-Mitsumoto , Satoshi Numazawa
Released: December 27, 2023
Abstract Full Text PDF[1M]
Supplemental Data
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Letter
Derivation of permitted daily exposure value for trifluoroacetic acid as an impurity in pharmaceutical products Vol.10, No.7, p.307-313
Hisakazu Sanada , Tsukasa Kikuno , Kimiyoshi Kitamura , Kiyohiro Hashimoto , Masayuki Mishima
Released: December 27, 2023
Abstract Full Text PDF[778K]
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Letter
Derivation of the permitted daily exposure value for p-tert-butylphenol as an impurity in pharmaceutical products Vol.10, No.7, p.301-306
Yasuyuki Ohnishi , Hisakazu Sanada , Masayuki Mishima , Kiyohiro Hashimoto
Released: December 27, 2023
Abstract Full Text PDF[779K]
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Letter
Derivation of permitted daily exposure value for 1,8-diazabicyclo[5.4.0]undec-7-ene in pharmaceutical products Vol.10, No.7, p.295-300
Haruna Tahara , Hisakazu Sanada , Masayuki Mishima , Yasuyuki Ohnishi , Yu Haranosono , Kiyohiro Hashimoto
Released: December 27, 2023
Abstract Full Text PDF[761K]
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Original Article
Development of an in silico consensus model for predicting the chemical reactivity to cysteine measured by the DPRA and its application to predict the skin sensitization potential of chemicals Vol.10, No.7, p.287-293
Koji Jojima , Yumi Akahori
Released: December 20, 2023
Abstract Full Text PDF[884K]
Supplemental Data
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Original Article
K16ApoE interrupts cerebral blood flow and induces blood cell aggregation in mice Vol.10, No.7, p.279-285
Linlin Shao , Toby M. Michelena
Released: December 15, 2023
Abstract Full Text PDF[7M]
Supplemental Data
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Original Article
Differential expression of Cytochrome P450 1A2 in simple fatty liver and steatohepatitis Vol.10, No.6, p.265-277
Azusa Kawashima , Naoto Uramaru , Toshiyasu Mikuma , Makoto Osabe , Toshiyuki Higuchi
Released: November 22, 2023
Abstract Full Text PDF[2M]
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Original Article
Titanium dioxide and silica nanoparticles inhibit the efflux of adriamycin in multi-drug resistant L1210/ADM cells Vol.10, No.6, p.259-264
Daisaku Miura , Teppei Koreeda , Naohiko Anzai , Ken-ichi Kiyomiya
Released: October 26, 2023
Abstract Full Text PDF[1M]
Supplemental Data
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Letter
Survey of toxicity study packages and designs of intravitreal drugs approved in Japan Vol.10, No.6, p.249-258
Kotaro Yamada , Yoshinori Yamagiwa , Yu Haranosono
Released: October 26, 2023
Abstract Full Text PDF[747K]
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Letter
Effects of expression of the 10-formyltetrahydrofolate metabolizing enzyme ALDH1L1 on pyrimidine nucleotide synthesis and the salvage pathway Vol.10, No.6, p.241-247
Masato Sasaki , Fumie Itoh , Nobuyuki Shibata
Released: October 26, 2023
Abstract Full Text PDF[4M]
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Original Article
Coffee diterpenes, cafestol and kahweol, display cytotoxicity and all-trans retinoic acid-induced superoxide generating activity-enhancing ability in U937 cells Vol.10, No.6, p.233-240
Hidehiko Kikuchi , Kaori Harata , Sumiko Akiyoshi , Takefumi Sagara , Harishkumar Madhyastha , Hitomi Mimuro , Futoshi Kuribayashi
Released: October 26, 2023
Abstract Full Text PDF[1M]
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Original Article
Effect of Anakinra (Kineret®) treatment on acrylamide-induced neurotoxicity in mice Vol.10, No.5, p.221-231
Alzahraa Fergany , Frederick Adams Ekuban , Cai Zong , Gaku Ichihara
Released: October 06, 2023
Abstract Full Text PDF[2M]
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Original Article
Subchronic oral toxicity study of Monascus Color in beagle dogs Vol.10, No.5, p.209-219
Akihiro Hagiwara , Yunagi Murase , Shuuhei Kubo , Haruko Koizumi , Mikio Nakamura , Shoji Fukushima
Released: September 25, 2023
Abstract Full Text PDF[836K]
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Original Article
Investigation of the maximum feasible volume of subretinal injections into rat and cynomolgus monkey eyes Vol.10, No.5, p.199-208
Megumi Sakata , Tomoaki Araki , Masayuki Tomohiro
Released: August 10, 2023
Abstract Full Text PDF[3M]
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Original Article
An application of the magnetometer detection system to Crl:CD1 (ICR) mice for head twitch response induced by hallucinogenic 5-HT2A agonists Vol.10, No.5, p.189-197
Mari Nakamura , Motoki Hojo , Ayaka Kawai , Kiyomi Ikushima , Akemichi Nagasawa , Hideyo Takahashi , Kosho Makino , Toshinari Suzuki , Jin Suzuki , Akiko Inomata
Released: August 10, 2023
Abstract Full Text PDF[4M]
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Letter
Effect of blood collection tubes containing separation gels on the measurement of drug concentrations in clinical toxicology Vol.10, No.5, p.179-187
Mayuu Tokudome , Asuka Kaizaki-Mitsumoto , Satoshi Numazawa
Released: August 04, 2023
Abstract Full Text PDF[1M]
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Original Article
Toxicological effects of repeated subcutaneous administration of corn oil for 4 weeks in rats Vol.10, No.4, p.169-178
Takayasu Moroki , Fumika Akizawa , Satoshi Kondo , Sakura Fujiwara , Tsuyoshi Yoshikawa , Yuki Inoue
Released: July 11, 2023
Abstract Full Text PDF[2M]
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Original Article
Evaluation of maximal dosing volume for intravitreal injections in cynomolgus monkeys Vol.10, No.4, p.157-167
Megumi Sakata , Tomoaki Araki , Masayuki Tomohiro
Released: July 04, 2023
Abstract Full Text PDF[4M]
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Data Report
Safety studies of LAURESH® a standardized Laurus nobilis leaf extract Vol.10, No.4, p.143-156
Chin Piow Wong , Yukiko Kobayashi , Jinwei Yang
Released: June 23, 2023
Abstract Full Text PDF[3M]
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Original Article
mRNA expression levels of CCL4, IL6, and CXCL2 in multiwalled carbon nanotube induced lung tumors in rats Vol.10, No.4, p.137-141
Nahida Sultana , Katsumi Fukamachi , Dipankar Chandra Roy , Jiegou Xu , Hiroyuki Tsuda , Masumi Suzui
Released: June 14, 2023
Abstract Full Text PDF[2M]
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Toxicomics Report
Effect of cadmium on expression of BIRC family genes in HeLa cells Vol.10, No.3, p.133-136
Jin-Yong Lee , Maki Tokumoto , Gi-Wook Hwang , Masahiko Satoh
Released: May 30, 2023
Abstract Full Text PDF[1M]
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Letter
K16ApoE inhibits the activity of acetylcholinesterase but is not the primary toxicological mechanism in mice Vol.10, No.3, p.125-131
Linlin Shao , Toby M. Michelena
Released: May 30, 2023
Abstract Full Text PDF[1M]
Supplemental Data
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Original Article
A trial to predict skin irritancy of cosmetic products using cytotoxicity tests Vol.10, No.3, p.113-123
Minori Mezaki , Chika Manabe , Junichiro Nagumo , Tomohisa Yoshimura , Tohru Nagahama , Hiroshi Itagaki , Akiko Takaoka
Released: May 12, 2023
Abstract Full Text PDF[1M]
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Minireview
A survey of on the use of genotoxicity and carcinogenicity testing packages for ophthalmic drug development Vol.10, No.3, p.105-112
Haruna Tahara , Yu Haranosono
Released: May 12, 2023
Abstract Full Text PDF[726K]
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Original Article
Derivation of human health hazard assessment values of 1,2-dichloroethane under the Japan Chemical Substances Control Law Vol.10, No.3, p.91-103
Akira Kawashima , Kaoru Inoue , Kazuo Ushida , Kaoru Kai , Hiroshi Suzuki , Lucia Satiko Yoshida-Yamashita , Akihiko Hirose , Kenichi Masumura
Released: April 14, 2023
Abstract Full Text PDF[706K]
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Retraction
Retraction: Quantitative morphometric analysis of vimentin filaments in Sertoli cells of rats after in utero DBP exposure
[Notice] The Original Article was published on May 13, 2017		 Vol.10, No.3, p.1-1
Eisuke Kume , Yuya Okayama , Mituru Sugiyama , Hiroyuki Takahashi , Tomoko Muto , Michael F. Wempe , Hiroshi Ikegami , Shin Wakui
Released: June 06, 2023
Abstract Full Text PDF[588K]
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Original Article
Effects of continuous thiamine intake on onset and progression of type 2 diabetes in leptin-receptor deficient mice Vol.10, No.2, p.83-90
Yuka Kohda
Released: March 27, 2023
Abstract Full Text PDF[2M]
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Data Report
A 90-day repeated oral dose toxicity study of 2-Butylbenzo[d]isothiazol-3(2H)-one in rats Vol.10, No.2, p.69-82
Makiko Kuwagata , Masaru Tsuboi , Toshime Igarashi , Mariko Tsurumoto , Takuya Nishimura , Yuhji Taquahashi , Satoshi Kitajima
Released: March 02, 2023
Abstract Full Text PDF[2M]
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Data Report
A 90-day dose toxicity study of 2-(2H-benzotriazol-2-yl)-6-dodecyl-4-methylphenol in rats Vol.10, No.2, p.59-68
Makiko Kuwagata , Masaru Tsuboi , Toshime Igarashi , Mariko Tsurumoto , Takuya Nishimura , Yuhji Taquahashi , Satoshi Kitajima
Released: March 02, 2023
Abstract Full Text PDF[1M]
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Original Article
Chlorella modulation of gut microbiota dysbiosis in patients with type-2 diabetes Vol.10, No.2, p.45-58
Fernanda Martins , Tamara C. Lopes de Castro , Andrey Santos , Dioze Guadagnini , Rose C. G. Trevisane , Ricardo P. Moreira , Edite Taninaga , Mario J. A. Saad , Mary L. S. Queiroz , Cristiane Okuda Torello
Released: February 24, 2023
Abstract Full Text PDF[2M]
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Original Article
Chlorella improves inflammatory profiles and quality of life of prediabetes and diabetes patients Vol.10, No.2, p.31-44
Fernanda Martins , Tamara C. Lopes de Castro , Sara T. Olalla Saad , Rose C. G. Trevisane , Ricardo P. Moreira , Edite Taninaga , Mary L. S. Queiroz , Cristiane Okuda Torello
Released: February 24, 2023
Abstract Full Text PDF[1M]
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Letter
mRNA expression profile of cytokines in rat primary alveolar macrophages treated with multiwalled carbon nanotube (MWCNT) Vol.10, No.1, p.27-30
Nahida Sultana , Katsumi Fukamachi , Jiegou Xu , Hiroyuki Tsuda , Masumi Suzui
Released: February 17, 2023
Abstract Full Text PDF[698K]
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Letter
DNA damage mediated by 4,4'-methylenebis(2-chloroaniline) cannot be detected via the DNA damage marker γH2AX: A case study Vol.10, No.1, p.21-25
Saho Kobayashi , Hiroki Kashiwagi
Released: February 15, 2023
Abstract Full Text PDF[1M]
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Original Article
Paternal exposure to methylphenidate induces ADHD-like behavioral phenotypes and altered gene expressions in mouse offspring Vol.10, No.1, p.7-20
Ryota Nakano , Asuka Kaizaki-Mitsumoto , Satoshi Numazawa
Released: February 01, 2023
Abstract Full Text PDF[2M]
Supplemental Data
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Toxicomics Report
PPAR gamma negatively regulates the expression of TRPM8 in normal epidermal cells but mutually regulate their expressions with TRPM8 by feed-back loop regulation in squamous carcinoma cells Vol.10, No.1, p.1-6
Tomofumi Fujino , Mizuki Nakamura , Saki Ohkawa
Released: January 13, 2023
Abstract Full Text PDF[1M]
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2022 - Vol. 9

Original Article
An in vitro microfluidic culture device for peripheral neurotoxicity prediction at low concentrations based on deep learning Vol.9, No.7, p.203-209
Xiaobo Han , Naoki Matsuda , Kazuki Matsuda , Makoto Yamanaka , Ikuro Suzuki
Released: December 23, 2022
Abstract Full Text PDF[3M]
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Letter
Transient increase in plasma urate induced by a single oral dose of fructose in rats Vol.9, No.7, p.197-202
Wataru Yoshioka , Mayuko Nagamura , Ryosuke Tanino , Akinari Shimada , Kimiyoshi Ichida
Released: December 02, 2022
Abstract Full Text PDF[747K]
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Original Article
Pharmaceutical concentrations and antimicrobial activity using hypersusceptible Escherichia coli lacking TolC component of multidrug efflux system in the Ayase River in Japan Vol.9, No.6, p.187-196
Tsuyoshi Murahashi , Jun-ichi Yamagishi , Kunihiko Nishino , Reika Takada , Takumi Sekine , Yoshikazu Matsuda , Toshiyuki Higuchi
Released: November 30, 2022
Abstract Full Text PDF[1M]
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Original Article
Role of cytoplasmic acetyltransferases, NAA60 and HAT1, in cellular protection against genotoxic agents Vol.9, No.6, p.179-186
Pasjan Satrimafitrah , Hideki Nishitoh , Yasunari Takami
Released: November 09, 2022
Abstract Full Text PDF[3M]
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Letter
Assessment of genotoxicity of 2-[2-(acetylamino)-4-[bis(2-hydroxyethyl)amino]-5-methoxyphenyl]-5-amino-7-bromo-4-chloro-2H-benzotriazole (PBTA-6) in zebrafish (Danio rerio) using the comet assay and micronucleus test Vol.9, No.6, p.173-178
Yuya Deguchi , Tomoyasu Toyoizumi , Hiroaki Nagaoka , Shuichi Masuda
Released: November 09, 2022
Abstract Full Text PDF[1M]
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Letter
Induction of CYP3A4 mRNA by cooked food-derived carcinogenic heterocyclic aromatic amines in human HPL-A3 cells Vol.9, No.6, p.167-172
Masashi Sekimoto , Natsuki Yamashita , Seiichiro Maeda , Masakuni Degawa
Released: October 28, 2022
Abstract Full Text PDF[1021K]
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Data Report
Comet assay of thyroid gland in rats treated with ethyl methanesulfonate Vol.9, No.5, p.163-166
Naho Tsuji , Soichiro Hagio , Kazuya Takeuchi , Satoshi Furukawa
Released: October 12, 2022
Abstract Full Text PDF[700K]
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Toxicomics Report
Deubiquitinase USP54 attenuates methylmercury toxicity in human embryonic kidney 293 cells Vol.9, No.5, p.159-162
Jin-Yong Lee , Jong-Mu Kim , Takuya Noguchi , Atsushi Matsuzawa , Akira Naganuma , Gi-Wook Hwang
Released: October 07, 2022
Abstract Full Text PDF[885K]
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Original Article
Bifunctional activity of tangeretin (5,6,7,8,4'-pentamethoxyflavone) in suppression of cell growth and gene expression of the superoxide-generating system-related proteins in U937 cells Vol.9, No.5, p.151-157
Hidehiko Kikuchi , Kaori Harata , Sumiko Akiyoshi , Takefumi Sagara , Harishkumar Madhyastha , Hitomi Mimuro , Futoshi Kuribayashi
Released: October 07, 2022
Abstract Full Text PDF[949K]
Supplemental Data
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Original Article
The effects on growth and reproductive function by parabens in C. elegans Vol.9, No.5, p.145-150
Yuko Sakaguchi , Nana Hirota , Satoshi Fukushima , Nobuhiro Ichikawa , Koji Arizono
Released: September 13, 2022
Abstract Full Text PDF[1M]
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Original Article
Cryopreserved human hepatocytes culture optimization on polymethylpentene oxygen permeable membranes for drug screening purposes Vol.9, No.4, p.135-144
Mathieu Anoy , Benedikt Scheidecker , Hiroshi Arakawa , Katsuhiro Esashika , Naoki Ishida , Hiroyasu Ito , Hisaaki Yanai , Jun Takahashi , Masaki Nishikawa , Yukio Kato , Yasuyuki Sakai
Released: September 07, 2022
Abstract Full Text PDF[2M]
Supplemental Data
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Original Article
Derivation of human health hazard assessment values for toluene under the Japanese Chemical Substances Control Law Vol.9, No.4, p.123-133
Akira Kawashima , Kaoru Inoue , Kazuo Ushida , Kaoru Kai , Hiroshi Suzuki , Mariko Matsumoto , Kenichi Masumura , Akihiko Hirose
Released: September 07, 2022
Abstract Full Text PDF[985K]
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Letter
Leaf extracts from Camellia sinensis and Argania spinosa suppress oxidative stress and chemokine release in human 3-dimensional cultured epidermis exposed to PM2.5 collected with cyclonic separation Vol.9, No.4, p.117-122
Maori Kono , Tomoaki Okuda , Masayuki Takaishi , Hidefumi Ikeda , Nami Ishihara , Yasuhiro Ishihara
Released: September 07, 2022
Abstract Full Text PDF[959K]
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Letter
De novo transgenerational inheritance of male rat hyperactivity by rotenone Vol.9, No.4, p.111-115
Masami Ishido
Released: September 07, 2022
Abstract Full Text PDF[1M]
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Original Article
Fecal microRNA223 as an indicator of recovery in chronic DSS colitis model in rats Vol.9, No.3, p.103-110
Terutaka Kodama , Yuko Togashi , Naomi Matsutani , Seiichiro Kurashige , Toyohiko Aoki , Yasuteru Otagiri
Released: July 06, 2022
Abstract Full Text PDF[1M]
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Original Article
Multigenerational effects of neonicotinoids (acetamiprid, clothianidin) on growth, fertility and motility of nematode C. elegans Vol.9, No.3, p.95-102
Yuko Sakaguchi , Saki Mikami , Naoko Ikoma , Sadahiro Kawazoe , Masaya Uchida , Nobuaki Tominaga , Koji Arizono , Nobuhiro Ichikawa
Released: July 06, 2022
Abstract Full Text PDF[2M]
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Original Article
Occupational exposure of pharmacists to drugs during tablet crushing and its countermeasures Vol.9, No.3, p.85-93
Tsuyoshi Murahashi , Miho Arai , Kengo Ogata , Manami Matsumoto , Toshiyuki Higuchi
Released: May 24, 2022
Abstract Full Text PDF[1M]
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Original Article
Genotoxicity and subchronic toxicity of a kaempferol aglycone-rich product produced from horseradish leaves Vol.9, No.3, p.71-83
Hiroki Kimoto , Sakura Fujiwara , Noriyuki Koyama , Tohru Uesugi
Released: May 19, 2022
Abstract Full Text PDF[933K]
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Original Article
Potential human health risks of mercury-contaminated cassavas – Preliminary studies Vol.9, No.2, p.61-69
Sylvester Addai-Arhin , Randy Novirsa , Hui Ho Jeong , Quang Dinh Phan , Nana Hirota , Yasuhiro Ishibashi , Hideki Shiratsuchi , Koji Arizono
Released: April 27, 2022
Abstract Full Text PDF[1M]
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Letter
Relationship between micronucleus formation and oxidative stress in human vascular endothelial cells under low dose rate irradiation Vol.9, No.2, p.47-59
Qingmei Meng , Ikue Hayashi , Kumiko Anno , Junya Kobayashi
Released: April 05, 2022
Abstract Full Text PDF[2M]
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Letter
Molecular network analysis of RNA viral infection pathway in diffuse- and intestinal-type gastric cancer Vol.9, No.2, p.37-46
Shihori Tanabe , Sabina Quader , Ryuichi Ono , Horacio Cabral , Kazuhiko Aoyagi , Akihiko Hirose , Hiroshi Yokozaki , Hiroki Sasaki
Released: April 05, 2022
Abstract Full Text PDF[4M]
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Letter
Absence of in vivo mutagenicity of 4,4'-oxybis(benzenesulfonohydrazide) in liver and glandular stomach of MutaTM Mouse Vol.9, No.2, p.31-36
Takako Iso , Masakatsu Natsume , Yasumasa Murata , Yoshiyuki Shigeta , Nozomu Hirose , Takaaki Umano , Katsuyoshi Horibata , Kenichi Masumura , Kei-ichi Sugiyama , Mariko Matsumoto , Akihiko Hirose
Released: April 05, 2022
Abstract Full Text PDF[860K]
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Erratum
Erratum: Utility of murine dendritic cell line DC2.4 for in vitro assay of skin-sensitization potential Vol.9, No.1, p.25-30
Erina Shiraishi , Akiko Ido , Youhei Hiromori , Kento Tanaka , Tomoki Kimura , Hisamitsu Nagase , Tsuyoshi Nakanishi
Released: March 16, 2022
Abstract Full Text PDF[1M]
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Erratum
Erratum: Safety assessment of a soluble dietary fiber, isomaltodextrin, enzymatically produced from starch Vol.9, No.1, p.23-23
Tsuyoshi SadakiyoSadakiyo , Shin-ichiro Inoue , Yuki Ishida , Hikaru Watanabe , Hitoshi Mitsuzumi , Shimpei Ushio
Released: February 28, 2022
Abstract Full Text PDF[509K]
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Letter
A novel high-purity carbon-nanotube yarn electrode used to obtain biopotential measurements in small animals: flexible, wearable, less invasive, and gel-free operation Vol.9, No.1, p.17-21
Yuhji Taquahashi , Shuji Tsuruoka , Koichi Morita , Masaki Tsuji , Kousuke Suga , Ken-ich Aisaki , Satoshi Kitajima
Released: January 18, 2022
Abstract Full Text PDF[1M]
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Letter
Dietary rapeseed (canola) oil suppresses testosterone production and increases plasma aldosterone level in stroke-prone spontaneously hypertensive rats (SHRSP) Vol.9, No.1, p.7-16
Mai Nishikawa , Naoki Ohara , Yukiko Naito , Chihiro Amma , Yoshiaki Saito , Kenjiro Tatematsu , Jinhua Baoyindugurong , Daisuke Miyazawa , Yoko Hashimoto , Harumi Okuyama
Released: January 15, 2022
Abstract Full Text PDF[2M]
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Letter
Glyceraldehyde 3-phosphate dehydrogenase converts methylmercury to its sulfur adduct with lowered toxicity through sulfane sulfur atoms on Cys247 Vol.9, No.1, p.1-5
Yumi Abiko , Eiko Yoshida , Yoshito Kumagai
Released: January 15, 2022
Abstract Full Text PDF[2M]
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2021 - Vol. 8

Original Article
Low-dose ionizing radiation suppresses the apoptosis-induced by serum-removal culture Vol.8, No.7, p.249-260
Yuki Nakamura , Shinsuke Katoh , Junya Kobayashi , Tomonobu Umeda , Yoshiko Kobayashi , Satoshi Numazawa
Released: December 31, 2021
Abstract Full Text PDF[3M]
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Original Article
Intake of wheat bran after administration of methylmercury reduces mercury accumulation in mice Vol.8, No.7, p.243-248
Masaaki Nagano , Masatake Fujimura
Released: December 31, 2021
Abstract Full Text PDF[795K]
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Original Article
Focus on orexin-A in obese diabetes rats: upregulation of orexin-A receptor in the diabetic brain Vol.8, No.7, p.235-241
Yuka Kohda
Released: December 25, 2021
Abstract Full Text PDF[846K]
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Letter
Time-dependent changes in serum concentrations of acyclovir and its metabolite, 9-carboxymethoxymethylguanine, in a patient with suspected acyclovir encephalopathy Vol.8, No.7, p.229-233
Kazumasa Abe , Asuka Kaizaki-Mitsumoto , Tomohiro Saito , Motonori Sugiyama , Hirokazu Honda , Satoshi Numazawa
Released: December 22, 2021
Abstract Full Text PDF[888K]
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Letter
Influence of trans-fatty acids on non-alcoholic steatohepatitis with hepatic fibrosis induced by a choline-deficient, methionine-lowered, L-amino acid-defined diet in male Harlan Sprague Dawley rats Vol.8, No.7, p.221-228
Kinuko Uno , Katsuhiro Miyajima , Marika Matsumoto , Marika Toma , Noriko Suzuki-Kemuriyama , Dai Nakae
Released: December 10, 2021
Abstract Full Text PDF[5M]
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Letter
Effects of intranasal administration of multi-walled carbon nanotube (MWCNT) suspension on respiratory syncytial virus (RSV) infection in mice Vol.8, No.7, p.215-220
Seiko Hashiguchi , Aki Miyauchi , Keiji Komemoto , Tomoyuki Ueda , Kenji Tokuda , Akihiko Hirose , Hiroki Yoshida , Toshi Akashi , Masahiko Kurokawa , Wataru Watanabe
Released: November 25, 2021
Abstract Full Text PDF[2M]
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Letter
Potency shift in immunomodulatory activities of zinc oxide (ZnO) nanoparticles in THP-1 cells is associated with cytotoxicity Vol.8, No.7, p.205-213
Atsuko Miyajima , Tsuyoshi Kawakami , Kaoru Komoriya , Reiko Kato , Makoto Usami , Kazuo Isama
Released: November 25, 2021
Abstract Full Text PDF[3M]
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Original Article
Quantitative structure-activity relationship and a category approach to support algal toxicity assessment of human pharmaceuticals Vol.8, No.7, p.195-204
Takashi Yamada , Tomoko Kawamura , Taeko Maruyama , Masayuki Kurimoto , Hiroshi Yamamoto , Naruo Katsutani , Akihiko Hirose
Released: November 16, 2021
Abstract Full Text PDF[2M]
Supplemental Data
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Original Article
Electroporation of thalidomide to medaka (Oryzias latipes) embryo for evaluation of developmental toxicity Vol.8, No.6, p.189-193
Yuki Nishiyama , Masaya Uchida , Aki Terada , Susumu Kono , Hiroshi Ishibashi , Koji Arizono , Nobuaki Tominaga
Released: November 09, 2021
Abstract Full Text PDF[1M]
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Letter
Improvement of a fish holding device for oral administration to zebrafish Vol.8, No.6, p.183-187
Naomi Fujiwara , Shinichi Nonaka , Yukiko Yanoue , Masao Tomiki , Miki Nishi , Shiro Toyohisa , Osamu Saika
Released: November 09, 2021
Abstract Full Text PDF[859K]
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Original Article
Expression of miRNAs in the colon, rectum, plasma, and feces in rats with dextran sulfate sodium Vol.8, No.6, p.177-182
Terutaka Kodama , Yuko Togashi , Naomi Matsutani , Seiichiro Kurashige , Toyohiko Aoki , Yasuteru Otagiri
Released: November 05, 2021
Abstract Full Text PDF[1M]
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Original Article
Development of an inhalation exposure system of a pressurized metered-dose inhaler (pMDI) formulation for small experimental animals Vol.8, No.6, p.169-175
Yuhji Taquahashi , Hirokatsu Saito , Makiko Kuwagata , Satoshi Kitajima
Released: October 28, 2021
Abstract Full Text PDF[2M]
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Original Article
Diverse unintended on-target mutations induced by zygote genome-editing using CRISPR/Cas9 system Vol.8, No.5, p.161-167
Toshime Igarashi , Yukuto Yasuhiko , Ryuichi Ono , Erika Tachihara , Miki Uchiyama , Atsuya Takagi , Yu Takahashi , Makiko Kuwagata , Satoshi Kitajima
Released: October 28, 2021
Abstract Full Text PDF[2M]
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Toxicomics Report
Knockdown of deubiquitinating enzyme Usp34 confers resistance to methylmercury in HEK293 cells Vol.8, No.5, p.157-160
Jong-Mu Kim , Jin-Yong Lee , Min-Seok Kim , Sawako Shindo , Takeshi Kumagai , Akira Naganuma , Gi-Wook Hwang
Released: October 20, 2021
Abstract Full Text PDF[907K]
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Original Article
Relationship between renal dysfunction and change in serum electrolyte levels in patients administered with liposomal amphotericin B Vol.8, No.5, p.147-155
Kaito Yamashiro , Atsushi Hirata , Ryosuke Ota , Fumihiko Ogata , Takehiro Nakamura , Naohito Kawasaki
Released: October 20, 2021
Abstract Full Text PDF[873K]
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Original Article
Extract of Siraitia grosvenorii (Luo Han Guo) protects against hepatic fibrosis in mice on a choline-deficient, methionine-lowered, L-amino acid-defined, high-fat diet without trans fatty acids Vol.8, No.5, p.135-145
Noriko Suzuki-Kemuriyama , Akari Abe , Sae Nakane , Kinuko Uno , Shuji Ogawa , Atsushi Watanabe , Ryuhei Sano , Megumi Yuki , Katsuhiro Miyajima , Dai Nakae
Released: October 20, 2021
Abstract Full Text PDF[4M]
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Original Article
Safety evaluation of 2-aza-8-oxohypoxanthine by in vitro skin sensitization and human tests Vol.8, No.4, p.123-133
Hisae Aoshima , Takunori Matsumoto , Rinta Ibuki , Hirokazu Kawagishi
Released: September 10, 2021
Abstract Full Text PDF[1M]
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Original Article
Health risk assessment on mercury, cadmium and lead in marketed cigarettes Vol.8, No.4, p.117-122
Quang Phan Dinh , Sylvester Addai-Arhin , Randy Novirsa , Huiho Jeong1 , Willy Cahya Nugraha , Pham Hung Viet , Nobuaki Tominaga , Yasuhiro Ishibashi , Koji Arizono
Released: September 08, 2021
Abstract Full Text PDF[758K]
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Original Article
Repeated-dose and reproductive/developmental toxicity screening of polyoxymethylene in rats Vol.8, No.4, p.103-116
Mariko Matsumoto , Sakiko Fujii , Nozomu Hirose , Takako Iso , Yoshiyuki Shigeta , Yasumasa Murata , Kaoru Inoue , Akihiko Hirose
Released: August 27, 2021
Abstract Full Text PDF[902K]
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Letter
Antidiabetic agent did not impair spermatogenesis in spontaneously hyperglycemic and diabetic rats Vol.8, No.4, p.97-101
Taiki Kobayashi , Takasumi Shimomoto , Junichi Namekawa , Masanobu Kanou , Hirotsugu Kato , Seishiro Sakamoto , Takeshi Iijima , Hideharu Ochiai
Released: August 02, 2021
Abstract Full Text PDF[849K]
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Original Article
Inorganic polyphosphate modulates leukocyte accumulation and vascular endothelial cell permeability and ameliorates cecal ligation and puncture-induced lethality Vol.8, No.3, p.89-96
Yoshitaka Yamazaki , Mikako Terashima-Hasegawa , Atsufumi Manabe , Toshikazu Shiba , Yumi Kawazoe , Takashi Ashino , Masahiro Hosonuma , Satoshi Numazawa
Released: July 27, 2021
Abstract Full Text PDF[1004K]
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Data Report
Movento® 240SC (Spirotetramat) and Envidor® 240SC (Spirodiclofen) keto-enol insecticides induce DNA damage in Drosophila melanogaster ovaries Vol.8, No.3, p.81-88
Berenyce González-Marín , María Elena Calderón-Segura , Ana Karen González Pérez , Luis Gerardo Moreno Ciénega
Released: July 27, 2021
Abstract Full Text PDF[923K]
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Original Article
Effects of the ethanol extract of Neopyropia yezoensis, cultivated in the Seto Inland Sea (Setonaikai), on the viability of 10 human cancer cells including endocrine therapy-resistant breast cancer cells Vol.8, No.3, p.75-80
Shuso Takeda , Masayo Hirao-Suzuki , Yukimasa Yamagishi , Takahiro Sugihara , Masataka Kaneko , Genki Sakai , Tetsuya Nakamura , Yuhzo Hieda , Masufumi Takiguchi , Masahiro Okada , Narumi Sugihara
Released: June 23, 2021
Abstract Full Text PDF[1M]
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Letter
Evaluation of the in vitro cytotoxicity of oscillatoxins E and F under nutrient-starvation culture conditions Vol.8, No.3, p.69-73
Yusuke Hanaki , Yusuke Araki , Toshio Nishikawa , Ryo C. Yanagita
Released: June 15, 2021
Abstract Full Text PDF[1M]
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Original Article
Effects of hemoglobin on post-mortem oxidation of bromazepam Vol.8, No.2, p.61-67
Yoshikazu Yamagishi , Hirotaro Iwase , Yasumitsu Ogra
Released: May 27, 2021
Abstract Full Text PDF[1M]
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Original Article
3’, 4’-Dihydroxyflavone enhances all-trans retinoic acid-induced superoxide-generating activity through up-regulating transcription of gp91-phox in human monoblastic U937 cells, as opposed to flavone and other hydroxyflavone derivatives Vol.8, No.2, p.53-59
Hidehiko Kikuchi , Kaori Harata , Sumiko Akiyoshi , Harishkumar Madhyastha , Futoshi Kuribayashi
Released: May 27, 2021
Abstract Full Text PDF[1M]
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Data Report
Acrylamide in dog food Vol.8, No.2, p.49-52
Kazutoshi Sugita , Junpei Yamamoto , Kimika Kaneshima , Chika Kitaoka-Saito , Masashi Sekimoto , Osamu Endo , Yukihiko Takagi , Yuko Kato-Yoshinaga
Released: May 21, 2021
Abstract Full Text PDF[750K]
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Original Article
A 90-day oral repeated-dose toxicity study of Monascus Color Y-001 in rats Vol.8, No.2, p.37-47
Yuko Doi , Taiki Sugiyama , Akihiro Hagiwara , Norio Imai , Yukinori Mera , Toyohiko Aoki
Released: May 21, 2021
Abstract Full Text PDF[785K]
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Data Report
A survey on the cadmium contamination in brown rice sold in Tokyo Vol.8, No.2, p.33-36
Yukino Segawa , Setsuko Tabata , Izumi Hirayama , Kenji Iida , Ikuko Matsuno , Hisako Nakano , Takeo Sasamoto , Toshiyuki Kaji
Released: April 22, 2021
Abstract Full Text PDF[876K]
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Original Article
The influence of long-term ingestion of D-allulose in hypercholesterolemia patients under statin therapy Vol.8, No.1, p.23-31
Misuzu Tanaka , Akane Kanasaki , Noriko Hayashi , Tetsuo Iida , Koji Murao
Released: April 22, 2021
Abstract Full Text PDF[833K]
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Letter
Ouabagenin, an aglycone of cardiotonic steroid ouabain, functions as LXR ligand but avoids the increase in the SREBP-1 by inducing Krüppel-like factor 15 Vol.8, No.1, p.17-22
Tomofumi Fujino , Kouta Sugizaki , Saki Ohkawa , Sana Fujikawa , Toshiyuki Oshima , Makio Hayakawa
Released: March 27, 2021
Abstract Full Text PDF[1M]
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Original Article
Genotoxicity of Monascus Color Y-001 Vol.8, No.1, p.7-16
Ryosuke Sato , Michihito Takabe , Takahiro Ishii , Norio Imai , Yuko Doi , Toyohiko Aoki
Released: March 09, 2021
Abstract Full Text PDF[747K]
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Toxicomics Report
Comprehensive analysis of the alteration of plasma miRNA expression level in mice exposed to diesel exhaust Vol.8, No.1, p.1-6
Ken Tachibana , Iori Kodaira , Noriko Kuroiwa , Ryo Uzuki , Yusuke Shinkai , Ken Takeda
Released: February 12, 2021
Abstract Full Text PDF[768K]
Supplemental Data
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2020 - Vol. 7

Original Article
Age-related hepatic glucose-dependent insulinotropic polypeptide expression is modified by ongoing thiamine supplementation in obese diabetic rats Vol.7, No.6, p.291-299
Yuka Kohda
Released: December 24, 2020
Abstract Full Text PDF[1M]
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Letter
Inhibitory effects of L-NAME, a nitric oxide synthase inhibitor, on decidual cell proliferation in mid-to-late pregnant rats Vol.7, No.6, p.287-289
Wataru Ishikawa , Shugo Kazama , Takehito Suzuki , Rei Yamana , Yoko Miyazaki , Kazuaki Tanaka , Makoto Usami , Tatsuya Takizawa
Released: December 24, 2020
Abstract Full Text PDF[1M]
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Letter
Influence of skin condition on the skin penetration of dextran 4000 and ovalbumin Vol.7, No.6, p.281-286
Makiko Fujii , Miko Imai , Hiroki Kuwabara , Minori Awano , Kaname Hashizaki , Hiroyuki Taguchi
Released: November 25, 2020
Abstract Full Text PDF[2M]
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Original Article
Combined repeated-dose and reproductive/developmental oral toxicity of 3-methylpentane, isooctane, and isononane in rats Vol.7, No.6, p.259-279
Akira Kawashima , Kaoru Inoue , Yoshiro Yoshizaki , Kazuo Ushida , Kaoru Kai , Hiroshi Suzuki , Masao Takano , Sakiko Fujii , Kaoru Yabe , Mariko Matsumoto , Takashi Yamada , Akihiko Hirose
Released: October 23, 2020
Abstract Full Text PDF[1M]
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Letter
Electromagnetic fields (EMF) facilitate cell migration and BrdU incorporation during an EMF-sensitive phase in a rat neurosphere assay in vitro Vol.7, No.6, p.253-257
Masami Ishido , Eiko Shimaya
Released: October 21, 2020
Abstract Full Text PDF[1M]
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Letter
In vitro cytotoxicity of the thyrotoxic and hepatotoxic rubber antioxidant 2-mercaptobenzimidazole and its 4- or 5-methyl derivatives in rabbit corneal cells Vol.7, No.6, p.249-252
Yukie Kuroda , Atsuko Miyajima , Kazue Sakemi-Hoshikawa , Makoto Usami , Katsuyoshi Mitsunaga , Yasuo Ohno , Momoko Sunouchi
Released: August 26, 2020
Abstract Full Text PDF[1M]
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Original Article
Lack of combined effect of continuous exposure to α-glycosyl isoquercitrin from fetal stages to adulthood and voluntary exercise or environmental enrichment on learning and behaviors in rats Vol.7, No.5, p.241-248
Yasunori Masubuchi , Satomi Kikuchi , Hiromu Okano , Yasunori Takahashi , Kazumi Takashima , Ryota Ojiro , Qian Tang , Toshinori Yoshida , Mihoko Koyanagi , Robert R. Maronpot , Shim-mo Hayashi , Makoto Shibutani
Released: August 18, 2020
Abstract Full Text PDF[1M]
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Original Article
Nucleolin positively regulates spontaneous cell proliferation but is not involved in inhibition of proliferation by lead in cultured bovine aortic endothelial cells Vol.7, No.5, p.233-239
Tsutomu Takahashi , Yuka Takagi , Yuta Honma , Yo Shinoda , Yayoi Tsuneoka , Takato Hara , Chika Yamamoto , Toshiyuki Kaji , Yasuyuki Fujiwara
Released: August 03, 2020
Abstract Full Text PDF[2M]
Supplemental Data
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Original Article
Four-week repeated dose oral toxicity study of gum ghatti in rats Vol.7, No.5, p.227-232
Ryo Kawahara , Kenichiro Watanabe , Rina Yamane , Hideki Yasui , Nao Kikugawa , Naoko Mori , Ryosuke Akiyama , Takeshi Matsubara , Miwa Harada , Shinya Kaneda
Released: July 31, 2020
Abstract Full Text PDF[883K]
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Original Article
The dietary intake of mercury from rice and human health risk in artisanal small-scale gold mining area, Indonesia Vol.7, No.5, p.215-225
Randy Novirsa , Quang Phan Dinh , Huihoa Jeong , Sylvester Addai-Arhin , Willy Cahya Nugraha , Nana Hirota , Bambang Wispriyono , Yasuhiro Ishibashi , Koji Arizono
Released: July 07, 2020
Abstract Full Text PDF[1M]
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Original Article
Safety evaluation of 2-aza-8-oxohypoxanthine based on in vitro and human patch tests Vol.7, No.5, p.207-214
Hisae Aoshima , Sayuri Hyodo , Rinta Ibuki , Jing Wu , Jae-Hoon Choi , Hirokazu Kawagishi
Released: June 19, 2020
Abstract Full Text PDF[1M]
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Original Article
Retinoic acid dramatically enhances cytotoxicity of equol against human monoblastic U937 cells, but not against human peripheral neutrophils Vol.7, No.4, p.201-206
Hidehiko Kikuchi , Kaori Harata , Chikage Kawai , Harishkumar Madhyastha , Akira Yamauchi , Futoshi Kuribayashi
Released: May 27, 2020
Abstract Full Text PDF[1M]
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Original Article
Postnatal wheel running mitigates endocrine disruption of mammary gland development in mice Vol.7, No.4, p.189-199
Emily E. Schmitt , Weston W. Porter , J. Timothy Lightfoot
Released: May 27, 2020
Abstract Full Text PDF[4M]
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Letter
Repeated 28-day and 13-week dose toxicity studies of oils prepared from the internal organs of the Japanese giant scallop (Patinopecten yessoensis) in rats Vol.7, No.4, p.177-188
Koki Sugimoto , Eito Shimizu , Nozomi Hagihara , Ryota Hosomi , Kenji Fukunaga , Munehiro Yoshida , Takeya Yoshioka , Koretaro Takahashi
Released: May 27, 2020
Abstract Full Text PDF[959K]
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Original Article
The aminoethyl group is a crucial structural moiety in metal-mediated oxidative DNA damage by catecholamines Vol.7, No.4, p.171-176
Koji Ueda , Yoshihiko Nishino , Yoshinori Okamoto , Nakao Kojima , Hideto Jinno
Released: May 19, 2020
Abstract Full Text PDF[1M]
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Letter
Bacteriological evaluation of feasibility of food poisoning from long-term stored “pack-cooked” meals Vol.7, No.4, p.167-170
Toshihiro Kobayashi , Harumi Sakuda
Released: May 19, 2020
Abstract Full Text PDF[851K]
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Letter
Combined exposure to environmental electrophiles enhances cytotoxicity and consumption of persulfide Vol.7, No.3, p.161-166
Masahiro Akiyama , Takamitsu Unoki , Yoshito Kumagai
Released: May 09, 2020
Abstract Full Text PDF[3M]
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Original Article
Usefulness of HepaRG cells in the mitochondrial function assay for the estimation of potential risk of idiosyncratic drug-induced liver injury Vol.7, No.3, p.153-160
Keisuke Goda , Taku Masuyama
Released: May 09, 2020
Abstract Full Text PDF[1M]
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Original Article
Maltosyltrehalose Syrup: Bacterial reverse mutation test, and 90-day feeding and 90-day repeated oral dose toxicity studies in rats Vol.7, No.3, p.141-152
Shuji Matsumoto , Takaharu Hashimoto , Chie Ushio , Keisuke Namekawa , Alan B. Richards
Released: April 22, 2020
Abstract Full Text PDF[1M]
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Original Article
Sex differences in the effects of high-fat diet on mouse sciatic nerves Vol.7, No.3, p.133-139
Masahiro Ogawa , Takahiro Kimura , Yoshitaka Tanetani , Masami Hori , Takahiro Kyoya , Megumi Terada
Released: April 15, 2020
Abstract Full Text PDF[1M]
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Original Article
In vitro toxicity studies of epoxyoleic acid and diepoxylinoleic acid Vol.7, No.3, p.123-132
Takashi Kitaguchi , Masaharu Tanaka , Takahiro Matsuda , Taisei Mizota , Katsutoshi Ohno , Kazuhiro Kobayashi , Yasumitsu Ogra , Mitsuru Tanaka
Released: April 15, 2020
Abstract Full Text PDF[5M]
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Letter
Effects of estrogen on fatty-acid-induced cytotoxicity in mouse Neuro-2a neural cells Vol.7, No.2, p.115-121
Masahiro Ogawa , Takahiro Kyoya , Takahiro Kimura , Megumi Terada
Released: March 27, 2020
Abstract Full Text PDF[1M]
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Original Article
Evaluation of cytokine storms in a disseminated intravascular coagulation monkey model Vol.7, No.2, p.105-114
Yoshitaka Hirasawa , Atsushi Fujiwara , Kazuya Tabata , Kenji Yoshida , Tsutomu Negama , Takayuki Anzai , Shin-ichi Sato
Released: March 27, 2020
Abstract Full Text PDF[2M]
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Original Article
5-Fluorocytosine induces fetal skeletal malformations in rats by altering expression of Homeobox genes Vol.7, No.2, p.97-103
Takayuki Kumamoto , Mika Senuma , Mai Todoroki , Fumiaki Kumagai , Hajime Imai , Reiko Suzuki , Tetsuo Ogawa , Makiko Kuwagata
Released: March 27, 2020
Abstract Full Text PDF[2M]
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Original Article
Utility of measuring long bone length in toxicity studies: results of a 14-day repeated dose oral toxicity study of dexamethasone in young, periadolescent and adult rats Vol.7, No.2, p.85-96
Chihiro Noguchi , Satoshi Tsuji , Yutaka Nakanishi , Minoru Sasaki
Released: March 03, 2020
Abstract Full Text PDF[6M]
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Original Article
Arsenite inhibits gene expression of perlecan, syndecan-1, -2, -3 and biglycan in cultured vascular endothelial cells Vol.7, No.2, p.77-83
Dong-pan Wu , Tsuyoshi Nakano , Yayoi Tsuneoka , Tsutomu Takahashi , Yo Shinoda , Toshiyuki Kaji , Yasuyuki Fujiwara
Released: March 03, 2020
Abstract Full Text PDF[1M]
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Original Article
Toxicological evaluation of DSPC (1,2-distearoyl-sn-glycero-3-phosphocholine) Vol.7, No.2, p.55-76
Osamu Ohgoda , Ian N. Robinson
Released: March 03, 2020
Abstract Full Text PDF[1009K]
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Original Article
Comparison of the liver findings after simvastatin-treatment between Spontaneously Diabetic Torii-Leprfa (SDT fatty) rats and Sprague-Dawley rats Vol.7, No.1, p.41-54
Tadakazu Takahashi , Yusuke Suzuki , Naohito Yamada , Kaoru Toyoda , Keisuke Goda , Katsunori Ryoke , Chizuru Matsuura , Akio Kobayashi , Shoichiro Sugai , Kayoko Shimoi
Released: January 28, 2020
Abstract Full Text PDF[3M]
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Original Article
Triphenyltin inhibits GA-binding protein α nuclear translocation Vol.7, No.1, p.33-40
Naohiro Kidoguchi , Keishi Ishida , Seigo Sanoh , Masatsugu Miyara , Yaichiro Kotake
Released: January 23, 2020
Abstract Full Text PDF[2M]
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Original Article
Safety and efficacy of a 48-week long-term ingestion of D-allulose in subjects with high LDL cholesterol levels Vol.7, No.1, p.15-31
Misuzu Tanaka , Akane Kanasaki , Noriko Hayashi , Tetsuo Iida , Koji Murao
Released: January 17, 2020
Abstract Full Text PDF[894K]
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Letter
Usefulness and limitations of mRNA measurement in HepaRG cells for evaluation of cytochrome P450 induction Vol.7, No.1, p.9-14
Kenta Mizoi , Yuuki Fukai , Eiko Matsumoto , Satoshi Koyama , Seiichi Ishida , Hajime Kojima , Takuo Ogihara
Released: January 15, 2020
Abstract Full Text PDF[1M]
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Original Article
Azoxystrobin at sub-cytotoxic concentrations disrupts intracellular zinc homeostasis: A flow cytometric analysis with rat thymic lymphocytes and fluorescent probes Vol.7, No.1, p.1-7
Mai Shoji , Masaki Asada , Akihiko Matsumoto , Haruki Nishino , Ao Yi Xiang , Mizuki Mizobuchi , Naoki Kanematsu , Hajime Miura , Norio Kamemura
Released: January 10, 2020
Abstract Full Text PDF[3M]
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2019 - Vol. 6

Original Article
Obesity-related hypertension and enhanced plasma orexin-A level are attenuated by the consumption of thiamine water in diabetic rats under cerebral oxidative stress conditions Vol.6, No.9, p.383-390
Yuka Kohda , Hitoshi Matsumura
Released: December 27, 2019
Abstract Full Text PDF[2M]
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Original Article
Safety evaluation of chicken breast meat extract in chromosomal aberration study, reverse mutation test, and 90-day repeated dose study in rats Vol.6, No.9, p.367-382
Yuasa Koki , Tadashi Imamura , Yasue Sakaguchi , Satoshi Kotoura
Released: December 19, 2019
Abstract Full Text PDF[2M]
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Original Article
Phospholipid and Triglyceride keep vortex-dispersed sulfur mustard analog as undissolved droplets which induce necrosis from nearby cells via declining mitochondrial membrane potential Vol.6, No.9, p.359-366
Feng Ye , Guorong Dan , Qinya Zeng , Mingliang Chen , Yuanpeng Zhao , Jin Cheng , Yan Sai , Jiqing Zhao , Zhongmin Zou
Released: December 13, 2019
Abstract Full Text PDF[6M]
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Original Article
Safety assessment of isomaltodextrin-producing enzymes from Paenibacillus alginolyticus Vol.6, No.9, p.341-357
Tsuyoshi Sadakiyo , Hikaru Watanabe , Hitoshi Mitsuzumi , Shimpei Ushio , Mai Sugi , Masakatsu Natsume
Released: December 11, 2019
Abstract Full Text PDF[1M]
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Original Article
Assessment of the acute toxicity of 16 veterinary drugs and a disinfectant to aquatic and soil organisms Vol.6, No.9, p.333-340
Noriko Usui , Masahito Ohara , Masaya Ito , Atsushi Noda , Yoshihiko Ito , Norio Hirayama
Released: December 11, 2019
Abstract Full Text PDF[1M]
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Original Article
Development of a hepatotoxicity prediction model using in vitro assay data of key molecular events Vol.6, No.8, p.327-332
Koji Jojima , Takashi Yamada , Akihiko Hirose
Released: December 11, 2019
Abstract Full Text PDF[925K]
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Original Article
Sulforaphane displays the growth inhibition, cytotoxicity and enhancement of retinoic acid-induced superoxide-generating activity in human monoblastic U937 cells Vol.6, No.8, p.319-325
Sumiko Akiyoshi , Hidehiko Kikuchi , Futoshi Kuribayashi , Harishkumar Madhyastha , Hisanori Minami
Released: December 11, 2019
Abstract Full Text PDF[1M]
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Original Article
Glucosyl hesperidin: safety studies Vol.6, No.8, p.299-317
Shuji Matsumoto , Takaharu Hashimoto , Chie Ushio , Keisuke Namekawa , Alan Blake Richards
Released: November 18, 2019
Abstract Full Text PDF[1M]
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Original Article
Carbamazepine-induced liver injury using type 2 diabetes Spontaneously Diabetic Torii-Leprfa (SDT fatty) rats as a model for human type 2 diabetes Vol.6, No.8, p.287-297
Tadakazu Takahashi , Chizuru Matsuura , Kaoru Toyoda , Yusuke Suzuki , Naohito Yamada , Akio Kobayashi , Shoichiro Sugai , Kayoko Shimoi
Released: November 18, 2019
Abstract Full Text PDF[4M]
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Letter
Transmission electron microscopy of the benzbromaroneinduced change in mitochondrial morphology in HepG2 cells Vol.6, No.8, p.281-286
Tomoyuki Sato , Akinori Takemura , Yugo Ikeyama , Yuriko Sakamaki , Ayako Mimata , Haruyo Aoyagi , Hideki Aizaki , Shuichi Sekine , Kousei Ito
Released: October 25, 2019
Abstract Full Text PDF[4M]
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Letter
A carrier protein is essential for the action of silver nanoparticles in an animal experiment Vol.6, No.7, p.277-279
Masami Ishido
Released: October 21, 2019
Abstract Full Text PDF[1M]
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Original Article
A 6-week repeated intranasal dose toxicity study of TTA-121, a novel oxytocin nasal spray, in cynomolgus monkeys Vol.6, No.7, p.269-275
Emi Matsumoto , Junichi Namekawa , Hideshi Kaneko , Takasumi Shimomoto , Mitsuaki Masuyama , Toshihisa Fujiwara , Daishiro Miura
Released: October 19, 2019
Abstract Full Text PDF[2M]
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Original Article
A 6-week repeated intranasal dose toxicity study of TTA-121, a novel oxytocin nasal spray, in rats Vol.6, No.7, p.259-268
Junichi Namekawa , Emi Matsumoto , Hideshi Kaneko , Takasumi Shimomoto , Takayuki Okamura , Takafumi Oshikata , Roger A. Renne , Daishiro Miura
Released: October 19, 2019
Abstract Full Text PDF[3M]
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Letter
Impact of dietary calcium and phosphorus levels on an ovariectomized Sprague-Dawley rat model of osteoporosis Vol.6, No.7, p.253-258
Atsushi Watanabe , Katsuhiro Miyajima , Noriko Kemuriyama , Hisashi Uchiyama , Takayuki Anzai , Hijiri Iwata , Reo Anzai , Dai Nakae
Released: October 11, 2019
Abstract Full Text PDF[4M]
Supplemental Data
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Letter
Localization of the trichloroethylene-related compound S-(1, 2-dichlorovinyl)-L-cysteine in mouse cartilage Vol.6, No.7, p.249-252
Norikazu Komoriya , Nobuaki Shirai , Hiroki Tomisawa , Hiromi Hagiwara
Released: October 09, 2019
Abstract Full Text PDF[1M]
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Letter
Comparison of cytotoxicity between fixed- and unfixed-combination ophthalmic solutions in vitro Vol.6, No.7, p.245-248
Kazuyo Sadamoto , Shingo Nemoto , Akio Kawamura , Masaaki Kurata
Released: October 09, 2019
Abstract Full Text PDF[795K]
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Original Article
High-dose β-carotene exacerbates high-fat/high-sucrose diet-inducible fibrosis in the liver of Mongolian gerbils Vol.6, No.6, p.235-243
Shinnosuke Kondo , Natsuyo Hariya , Kazuki Mochizuki
Released: September 20, 2019
Abstract Full Text PDF[4M]
Supplemental Data
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Original Article
Safety evaluation of 12-week continuous ingestion of D-allulose in borderline diabetes and type 2 diabetes Vol.6, No.6, p.225-234
Misuzu Tanaka , Noriko Hayashi , Tetsuo Iida
Released: September 20, 2019
Abstract Full Text PDF[845K]
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Original Article
Recovery of increased weights of the liver and kidneys by cessation of D-allulose feeding in Wistar rats Vol.6, No.6, p.217-224
Masaru Ochiai , Kei Ohkubo , Masako Nakamura , Takako Yamada , Tetsuo Iida , Tatsuhiro Matsuo
Released: September 05, 2019
Abstract Full Text PDF[3M]
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Original Article
Procyanidin protects HK-2 cells against cisplatin-induced injury through antioxidant action involving Nrf2/HO-1 signaling pathway Vol.6, No.6, p.207-215
Cheng Chen , Xi Feng , Ran Jing , Yushang Tang , Wanfen Zhang , Tongqiang Liu
Released: September 05, 2019
Abstract Full Text PDF[3M]
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Original Article
Multi-site study of an in vivo phototoxicity evaluation in Sprague-Dawley (SD) rats aimed at incorporating the phototoxicity assessments: effects of repeated administration and toxicokinetic blood collection on drug-induced phototoxicity Vol.6, No.6, p.197-206
Yutaka Yonezawa , Hitoshi Katou , Kazuhiro Kuga
Released: August 27, 2019
Abstract Full Text PDF[2M]
Supplemental Data
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Letter
Oral toxicity study of an antiprion compound N,N’-[(cyclohexylmethylene)di-4,1-phenylene]bis[2-(1-pyrrolidinyl) acetamide] in rats and cynomolgus monkeys Vol.6, No.5, p.187-195
Junji Hosokawa-Muto , Tsutomu Kimura , Kazuo Kuwata
Released: August 01, 2019
Abstract Full Text PDF[1M]
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Original Article
Species difference in antimony and arsenic metabolism between hamster and rat after administration of tri- or pentavalent inorganic antimony Vol.6, No.5, p.181-185
Quan Zhou , Yu-ki Tanaka , Noriyuki Suzuki , Yasumitsu Ogra
Released: August 01, 2019
Abstract Full Text PDF[1M]
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Original Article
Multi-site study of an in vivo phototoxicity evaluation in Sprague-Dawley rats: skin site and sex differences in sensitivity to drug-induced phototoxicity Vol.6, No.5, p.171-179
Kazuhiro Kuga , Yutaka Yonezawa , Hitoshi Katou
Released: August 01, 2019
Abstract Full Text PDF[2M]
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Letter
Methylmercury causes neuronal cell death via M1-microglial activation in organotypic slices prepared from mouse cerebral cortex Vol.6, No.5, p.167-170
Takayuki Hoshi , Takashi Toyama , Akira Naganuma , Gi-Wook Hwang
Released: July 02, 2019
Abstract Full Text PDF[2M]
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Original Article
Comprehensive toxicity evaluation of cyclopentyl methyl ether (CPME) for establishing a permitted daily exposure level Vol.6, No.5, p.145-165
Kaoru Inoue , Hiroshi Suzuki , Takashi Yamada
Released: June 25, 2019
Abstract Full Text PDF[1017K]
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Letter
Genotoxicity evaluation of oil prepared from the internal organs of the Japanese giant scallop (Patinopecten yessoensis) Vol.6, No.4, p.137-143
Koki Sugimoto , Ryota Hosomi , Kenji Fukunaga , Takaki Shimono , Seiji Kanda , Toshimasa Nishiyama , Munehiro Yoshida , Takeya Yoshioka , Koretaro Takahashi
Released: June 13, 2019
Abstract Full Text PDF[797K]
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Original Article
Validation of the statistical parameters and model selection criteria of the benchmark dose methods for the evaluation of various endpoints in repeated-dose toxicity studies Vol.6, No.4, p.125-136
Mariko Matsumoto , Mutsuko Hirata-Koizumi , Tomoko Kawamura , Sawako Sakuratani , Atsushi Ono , Akihiko Hirose
Released: May 17, 2019
Abstract Full Text PDF[7M]
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Toxicomics Report
Gene expression profiles of immortalized S1, S2, and S3 cells derived from each segment of mouse kidney proximal tubules Vol.6, No.4, p.117-123
Hitomi Fujishiro , Seiichiro Himeno
Released: May 14, 2019
Abstract Full Text PDF[746K]
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Letter
Impairment of fertilization efficiency in mice following nano-sized titanium exposure Vol.6, No.3, p.113-116
Nobuhiko Miura , Katsumi Ohtani , Tatsuya Hasegawa , Gi-Wook Hwang , Hiroki Yoshioka
Released: May 14, 2019
Abstract Full Text PDF[914K]
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Letter
Magnoliae Cortex extract protects PC12 cells from cytotoxicity induced by hydrogen peroxide or 6-hydroxydopamine through enzyme induction Vol.6, No.3, p.107-112
Takahito Nishiyama , Yasuhiro Masuda , Tadashi Izawa , Tomokazu Ohnuma , Kenichiro Ogura , Akira Hiratsuka
Released: April 24, 2019
Abstract Full Text PDF[1M]
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Original Article
Genotoxicity and subchronic toxicity studies of Taiwanofungus camphoratus extract Vol.6, No.3, p.81-106
Jian-Yu Lin , Mei-Chun Chen , Emerson Chiu
Released: April 05, 2019
Abstract Full Text PDF[2M]
Supplemental Data
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Original Article
Age-dependent aggravation of oral malodor and periodontal disease in dogs Vol.6, No.3, p.75-79
Naoki Iwashita , Kazutoshi Sugita , Sayaka Murata , Keiko Ichimura , Mitsuyuki Shirai , Masaharu Hisasue , Miyoko Saito , Takuma Aoki , Yukihiko Takagi , Fumitoshi Asai
Released: April 04, 2019
Abstract Full Text PDF[743K]
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Original Article
Twenty-eight-day oral toxicity study of L-hydroxyproline in rats with 14-day post-treatment observation period Vol.6, No.3, p.65-74
Saori Akiduki , Yoko Kawada , Fumiko Watanabe , Toshikazu Kamiya , Koji Morishita
Released: April 04, 2019
Abstract Full Text PDF[1M]
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Original Article
Effects of benzotriazole ultraviolet stabilizers on rat PXR, CAR and PPARα transcriptional activities Vol.6, No.2, p.57-63
Yoko Watanabe , Shoko Hattori , Chieri Fujino , Ken Tachibana , Hiroyuki Kojima , Kouichi Yoshinari , Shigeyuki Kitamura
Released: March 19, 2019
Abstract Full Text PDF[1M]
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Original Article
Cytotoxic effects of parathion, paraoxon, and their methylated derivatives on a mouse neuroblastoma cell line NB41A3 Vol.6, No.2, p.45-56
Yunbiao Wang , ByungHoon Kim , Ashley Walker , Shayla Williams , Ashley Meeks , Yong-Jin Lee , Seong S. Seo
Released: March 12, 2019
Abstract Full Text PDF[2M]
Supplemental Data
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Original Article
Acute hepatotoxicity and drug/chemical interaction toxicity of 10-nm silver nanoparticles in mice Vol.6, No.2, p.37-44
Katsuhiro Isoda , Naoki Kobayashi , Yuichiro Taira , Ikuko Taira , Yoshimi Shimizu , Yoshihiro Akimoto , Hayato Kawakami , Isao Ishida
Released: March 06, 2019
Abstract Full Text PDF[4M]
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Toxicomics Report
Effects of lithium on developmental toxicity, teratogenicity and transcriptome in medaka embryos Vol.6, No.2, p.31-36
Nobuaki Tominaga , Seiya Shino , Masaya Uchida , Hiroshi Ishibashi , Midori Iida , Tadashi Okobira , Kayla Arizono , Noriaki Yoshida , Koji Arizono
Released: February 15, 2019
Abstract Full Text PDF[2M]
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Letter
Protective effect of the Kampo formula “Juzen-taiho-to” on isoniazid- and rifampicin-induced hepatotoxicity in mice Vol.6, No.1, p.25-29
Hiroki Yoshioka , Shiori Fukaya , Sarah Tominaga , Akito Nagatsu , Nobuhiko Miura , Tohru Maeda
Released: February 06, 2019
Abstract Full Text PDF[1M]
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Original Article
Supplementation with lower doses of EGCg reduces liver injury markers of type 2 diabetic rats Vol.6, No.1, p.15-23
Kazuki Mochizuki , Yu Tan , Yumiko Uchiyama , Takuji Suzuki , Natsuyo Hariya , Toshinao Goda
Released: January 30, 2019
Abstract Full Text PDF[1M]
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Letter
Investigation of DNA damage of glycidol and glycidol fatty acid esters using Fpg-modified comet assay Vol.6, No.1, p.9-14
Ryo Inagaki , Kohei Uchino , Yuko Shimamura , Shuichi Masuda
Released: January 18, 2019
Abstract Full Text PDF[2M]
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Original Article
Thiamine supplementation modulates oxidative stress by inhibiting hepatic adenosine diphosphate (ADP)-ribosylation in obese diabetic rats Vol.6, No.1, p.1-8
Yuka Kohda , Junpei Ueda , Rie Azuma , Yuuka Nakatani , Hiroto Murase , Kanta Matsui , Yuka Takezoe , Eiko Nagata , Risa Matsui , Takao Tanaka , Hitoshi Matsumura
Released: January 16, 2019
Abstract Full Text PDF[2M]
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2018 - Vol. 5

Toxicomics Report
Cyclin-dependent kinase inhibitor p21/Cip1 down-regulates the expression of proteasome activator PA28γ in normal hepatocyte-derived cells Vol.5, No.6, p.203-207
Tomofumi Fujino , Toshiyuki Oshima , Makio Hayakawa
Released: December 28, 2018
Abstract Full Text PDF[1M]
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Minireview
The temporal turning window for rat behavioral phenotypes by rotenone Vol.5, No.6, p.195-202
Masami Ishido
Released: December 28, 2018
Abstract Full Text PDF[13M]
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Original Article
Study of metabolic activation of the UV-filter octyl methoxycinnamate for endocrine-disrupting activity Vol.5, No.6, p.185-193
Yoko Watanabe , Chihiro Emori , Naoto Uramaru , Nariaki Fujimoto , Shigeyuki Kitamura
Released: December 18, 2018
Abstract Full Text PDF[1M]
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Letter
A zinc complex that suppresses the expression of a reactive sulfur species-producing enzyme, cystathionine γ-lyase, in cultured vascular endothelial cells Vol.5, No.6, p.181-184
Akane Takahashi , Musubu Takahashi , Tomoya Fujie , Takato Hara , Eiko Yoshida , Chika Yamamoto , Toshiyuki Kaji
Released: December 11, 2018
Abstract Full Text PDF[2M]
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Original Article
Effects of fish oil-enriched Sasa-kamaboko diet in decreasing hepatic lipid levels in a mouse fatty liver disease model Vol.5, No.5, p.171-179
Masaaki Miyata , Tomoki Kinoshita , Kaho Miyahara , Mizuki Sato , Asaka Arikawa , Yoshimasa Sugiura , Yoshihisa Suzuki , Emiko Okazaki
Released: November 21, 2018
Abstract Full Text PDF[2M]
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Original Article
Derivation of acceptable daily exposure value for alanine, N,N-bis(carboxymethyl)-, trisodium salt Vol.5, No.5, p.167-170
Masayuki Mishima , Dana Hoffmann , Gaku Ichihara , Satoshi Kitajima , Makoto Shibutani , Satoshi Furukawa , Akihiko Hirose
Released: November 06, 2018
Abstract Full Text PDF[794K]
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Letter
Protection from acetaminophen-induced hepatotoxicity by post-administration of 1O, 20O-diacetyl kamebakaurin in mice Vol.5, No.5, p.161-165
Hiroki Yoshioka , Hiroyuki Ohnishi , Masae Yoshikawa , Ming-Yu Gui , Yong-Ri Jin , Xu-Wen Li , Yoshiyuki Adachi , Naohito Ohno , Koichi Takeya , Yukio Hitotsuyanagi , Nobuhiko Miura , Yutaka Aoyagi
Released: October 19, 2018
Abstract Full Text PDF[3M]
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Original Article
In utero exposure to 2,2’,4,4’,5,5’-hexachlorobiphenyl accelerates the onset of eye opening in rat offspring Vol.5, No.4, p.153-159
Kenichi Kobayashi , Muneyuki Miyagawa , Rui-Sheng Wang , Megumi Suda , Soichiro Sekiguchi , Takeshi Honma
Released: October 16, 2018
Abstract Full Text PDF[1M]
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Letter
Positions and numbers of hydroxyl groups in hydroxychalcone derivatives are involved in cytotoxicity against human monoblastic U937 cells Vol.5, No.4, p.149-152
Hidehiko Kikuchi , Futoshi Kuribayashi , Harishkumar Madhyastha
Released: September 29, 2018
Abstract Full Text PDF[929K]
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Original Article
Anatomical and histological sex differences in the eye and its accessory tissues in Dutch belted rabbits Vol.5, No.4, p.141-147
Gakushi Kito , Ikuyo Atsumi , Yoshinori Yamagiwa , Hideyuki Sakaki , Masaaki Kurata
Released: July 18, 2018
Abstract Full Text PDF[611K]
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Original Article
Carcinogenicity study of poly-trans-[(2-carboxyethyl)germasesquioxane] (Ge-132) in F344 rats Vol.5, No.4, p.127-140
Katsuharu Iwadate , Yukari Yamaguchi , Mai Sasaki , Mikiya Nakatani , Yuko Doi , Norio Imai , Seiko Tamano , Yorifumi Nishihori
Released: July 10, 2018
Abstract Full Text PDF[423K]
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Letter
The impact on the activity of acetylcholinesterase of a polylysine-ApoE peptide carrier targeting the blood brain barrier Vol.5, No.4, p.123-126
Toby M. Michelena , Xuechen Tian , Xuan Zhou , Yu Meng
Released: July 03, 2018
Abstract Full Text PDF[212K]
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Letter
Chlorella supplementation decreases methylmercury concentrations of hair and blood in healthy volunteers Vol.5, No.3, p.117-122
Isao Maruyama , Takuya Uchikawa , Toshihiro Kanno , Yotaro Ando , Hisao Kitsuki , Akira Yasutake
Released: June 22, 2018
Abstract Full Text PDF[350K]
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Letter
In vitro metabolism of 4-methyl- and 5-methyl-2-mercaptobenzimidazole, thyrotoxic and hepatotoxic rubber antioxidants, in rat liver microsomes Vol.5, No.3, p.113-116
Atsuko Miyajima , Yukie Kuroda , Kazue Sakemi-Hoshikawa , Makoto Usami , Katsuyoshi Mitsunaga , Tomohiko Irie , Yasuo Ohno , Momoko Sunouchi
Released: June 19, 2018
Abstract Full Text PDF[728K]
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Original Article
The Kampo formula “Juzen-taiho-to” exerts protective effects on ethanol-induced liver injury in mice Vol.5, No.3, p.105-112
Shiori Fukaya , Akito Nagatsu , Hiroki Yoshioka
Released: June 19, 2018
Abstract Full Text PDF[5M]
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Original Article
Biphenyl increases the intracellular Ca2+ concentration in HL-60 cells Vol.5, No.3, p.99-103
Tomoko Inubushi , Mayumi Sugimoto , Haruka Kunimi , Haruka Hino , Atsushi Tabata , Naohiro Imura , Shin Abe , Norio Kamemura
Released: June 01, 2018
Abstract Full Text PDF[305K]
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Letter
Effect of heat shock protein gene expression on cadmium toxicity in human proximal tubular cells Vol.5, No.3, p.93-97
Jin-Yong Lee , Maki Tokumoto , Gi-Wook Hwang , Masahiko Satoh
Released: May 30, 2018
Abstract Full Text PDF[594K]
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Original Article
Cadmium, arsenic and lead accumulation in rice grains produced in Senegal river valley Vol.5, No.2, p.87-91
Moussa Ndong , Nathan Mise , Masaki Okunaga , Fujio Kayama
Released: May 22, 2018
Abstract Full Text PDF[206K]
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Letter
Risk assessment of reproductive and developmental toxicity in eye-drop drugs: a consideration based on threshold of toxicological concern Vol.5, No.2, p.83-85
Masaaki Kurata , Gakushi Kito , Kazuyo Sadamoto , Shingo Nemoto
Released: April 25, 2018
Abstract Full Text PDF[455K]
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Letter
Male-specific prolongation of prothombin time by industrial chemicals Vol.5, No.2, p.75-82
Takashi Yamada , Yushiro Tanaka , Ryuichi Hasegawa , Toshime Igarashi , Akihiko Hirose
Released: April 18, 2018
Abstract Full Text PDF[1M]
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Toxicomics Report
Putrescine selectively alleviates methylmercury toxicity in C17.2 mouse neural stem cells Vol.5, No.2, p.71-73
Masayuki Sato , Jin-Yong Lee , Min-Seok Kim , Tsutomu Takahashi , Akira Naganuma , Gi-Wook Hwang
Released: April 18, 2018
Abstract Full Text PDF[906K]
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Letter
Assessment of bladder DNA damage due to 2-acetylaminofluorene, diuron, and terephthalic acid by the rat comet assay Vol.5, No.1, p.63-69
Takahiro Kyoya , Rika Iwamoto , Yuko Shimamura , Megumi Terada , Shuichi Masuda
Released: March 20, 2018
Abstract Full Text PDF[801K]
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Letter
Scanning electron microscopic analysis of the bladder epithelium in terephthalic acid administered rats: a case in acute toxicity study Vol.5, No.1, p.57-62
Takahiro Kyoya , Megumi Terada
Released: March 09, 2018
Abstract Full Text PDF[3M]
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Original Article
Abundant migration of midazolam and 1’-hydroxymidazolam into the fetal brain following midazolam administration to pregnant mice in the second trimester Vol.5, No.1, p.49-56
Satoshi Kitaoka , Jo Hatogai , Nanako Niikura , Miho Hirata , Nanako Fukasawa , Satoru Miyazaki , Naoto Yamaguchi , Shohei Harada , Masanaho Sasatsu , Kiyoshi Sugiyama , Wataru Ochiai
Released: March 07, 2018
Abstract Full Text PDF[513K]
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Original Article
Subacute toxicity evaluation of KMRC011, a Toll-like receptor-5 agonist administered by intramuscular injection to rats Vol.5, No.1, p.33-48
Min-Sung Kang , Min-Seok Kim , Sung-Hwan Kim , Doin Jeon , Hyeon-Young Kim , Kwang-Hyun Lim , Su-Cheol Han , Kyuhong Lee , Woo-Jong Lee , Chi-Min Choi , Hong-Soo Lee , Jong-Choon Kim
Released: March 07, 2018
Abstract Full Text PDF[3M]
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Original Article
Comparison of stabilities of nitrenium ions and in vitro and in vivo genotoxic potential, between four aniline derivatives Vol.5, No.1, p.21-32
Hidekazu Suzuki , Takuya Ninoseki , Ayumi Hayashi , Yasunori Hase , Takuya Matsui , Masaru Naito , Shoichiro Sugai
Released: February 21, 2018
Abstract Full Text PDF[255K]
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Original Article
Increased hepatic triglyceride level induced by a glucokinase activator in mice Vol.5, No.1, p.13-20
Junichi Namekawa , Mari Yasui , Atsuko Katayanagi , Mitsuyuki Shirai , Fumitoshi Asai
Released: February 06, 2018
Abstract Full Text PDF[1M]
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Original Article
A 28-day repeated oral-dose toxicity study of insecticide synergist N-(2-ethylhexyl)-1-isopropyl-4-methylbicyclo[2.2.2] oct-5-ene-2,3-dicarboximide in rats Vol.5, No.1, p.1-11
Mariko Matsumoto , Masatoshi Furukawa , Katsumi Kobayashi , Takako Iso , Toshime Igarashi , Takashi Yamada , Akihiko Hirose
Released: January 19, 2018
Abstract Full Text PDF[254K]
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2017 - Vol. 4

Original Article
General toxicity of a vitamin K1 2,3-epoxide reductase (VKOR) inhibitor, 3-acetyl-5-methyltetronic acid, in rats Vol.4, No.6, p.285-293
Masashi Uchida , Yuka Sakaguchi , Yohei Miyamoto
Released: December 26, 2017
Abstract Full Text PDF[597K]
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Original Article
Hepatic glucose-dependent insulinotropic polypeptide expression is modified by supplementing high-dose thiamine in obese diabetic rats Vol.4, No.6, p.279-284
Yuka Kohda , Akie Maekita , Takao Tanaka , Hitoshi Matsumura
Released: December 21, 2017
Abstract Full Text PDF[1M]
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Letter
Effect of chronic cadmium exposure on the gene expression of Birc family in the mouse kidney and liver Vol.4, No.6, p.275-278
Jin-Yong Lee , Maki Tokumoto , Gi-Wook Hwang , Masahiko Satoh
Released: December 21, 2017
Abstract Full Text PDF[1M]
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Original Article
Effect of metallothionein on ethanol-induced hepatotoxicity in mice Vol.4, No.6, p.269-273
Maki Tokumoto , Kiyoshi Shibuya , Jin-Yong Lee , Chiharu Tohyama , Masahiko Satoh
Released: December 15, 2017
Abstract Full Text PDF[1M]
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Original Article
Suppressive effect of Sasa veitchii extract on obesity induced by a high-fat diet through modulation of adipose differentiation in mice Vol.4, No.6, p.261-268
Hiroki Yoshioka , Mihoko Mori , Masae Yoshikawa , Hirohisa Fujii , Akito Nagatsu , Tsunemasa Nonogaki
Released: December 13, 2017
Abstract Full Text PDF[1M]
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Original Article
Toxicity of repeated 28-day oral administration of acenaphthylene in rats Vol.4, No.6, p.247-259
Shihori Tanabe , Katsumi Kobayashi , Mariko Matsumoto , Hideki Serizawa , Toshime Igarashi , Takashi Yamada , Akihiko Hirose
Released: November 07, 2017
Abstract Full Text PDF[219K]
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Letter
In vitro genotoxicity test package of antibiotics for human use submitted to the Japanese regulatory agency during 2004–2015 Vol.4, No.5, p.241-245
Shin-ichi Sekizawa , Yukiko Hoshino , Aiko Takasu
Released: October 18, 2017
Abstract Full Text PDF[306K]
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Original Article
CYP3A4 induction mechanism of polycyclic aromatic hydrocarbons differs from that of rifampicin in PXR binding element Vol.4, No.5, p.229-239
Yusuke Aratsu , Reo Odagiri , Rie Shoji , Kouki Watanabe , Takeshi Kumagai , Sawako Shindo , Takamitsu Sasaki , Kiyoshi Nagata
Released: October 05, 2017
Abstract Full Text PDF[909K]
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Original Article
A 4-week oral gavage toxicity study of L-citrulline in rats Vol.4, No.5, p.219-227
Masahiko Morita , Tsuyoshi Yamaguchi , Koji Morishita , Ayako Kamimura
Released: September 27, 2017
Abstract Full Text PDF[680K]
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Original Article
Toxicity in repeated 28-day oral administration of N-phenyl-1-naphthylamine in rats Vol.4, No.5, p.207-218
Shihori Tanabe , Masahito Ohara , Masaya Ito , Atsushi Noda , Katsumi Kobayashi , Mariko Matsumoto , Akihiko Hirose
Released: September 13, 2017
Abstract Full Text PDF[211K]
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Letter
Organophosphorus insecticide dichlorvos inhibits fatty acid amide hydrolase in the male reproductive organs of rats Vol.4, No.5, p.201-205
Naoko Oya , Yuki Ito , Michihiro Kamijima
Released: August 30, 2017
Abstract Full Text PDF[1M]
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Toxicomics Report
Expression levels of 39 Cyp mRNAs in the mouse brain and neuroblastoma cell lines, C-1300N18 and NB2a – strong expression of Cyp1b1 Vol.4, No.5, p.195-200
Satoshi Yamaori , Rongrong Jiang , Chikako Maeda , Risa Ogawa , Hiroyuki Okazaki , Hironori Aramaki , Kazuhito Watanabe
Released: August 24, 2017
Abstract Full Text PDF[184K]
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Letter
A new insight into proliferative action of bisphenol A at low-dose Vol.4, No.4, p.191-193
Masami Ishido , Rumiko Usu
Released: July 22, 2017
Abstract Full Text PDF[219K]
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Letter
HSP70-Ran-RCC1 transport system during cadmium-induced apoptosis in porcine kidney LLC-PK1 cells Vol.4, No.4, p.187-189
Masami Ishido , Rumiko Usu
Released: July 22, 2017
Abstract Full Text PDF[482K]
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Original Article
Disposition of perfluorododecanoic acid in male rats after oral administration Vol.4, No.4, p.179-186
Kohei Kawabata , Suzuka Tamaki , Eri Kokubo , Yukari Kobayashi , Tomoya Shinohara , Ayako Sakai , Hiroshi Kawai , Atsushi Mitsumoto , Yoichi Kawashima , Naomi Kudo
Released: July 20, 2017
Abstract Full Text PDF[394K]
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Letter
Cytometric analysis on cytotoxicity of 4,4′-methylenediphenyl diisocyanate, a chemical allergen, in rat thymocytes Vol.4, No.4, p.173-178
Keisuke Oyama , Norikazu Miyoshi , Yasuo Oyama
Released: July 08, 2017
Abstract Full Text PDF[1M]
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Letter
Predicting clinical cardiotoxicity caused by trastuzumab and E-8010 using human cardiomyocytes Vol.4, No.4, p.167-171
Nobuo Aikawa
Released: July 04, 2017
Abstract Full Text PDF[216K]
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Original Article
Distinct regulation of nuclear localization of caspase-activated DNase during cadmium-induced apoptosis of the target cells Vol.4, No.3, p.159-165
Masami Ishido , Rumiko Usu
Released: June 30, 2017
Abstract Full Text PDF[1M]
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Original Article
Orally administered p-nitrotoluene causes hyperactivity, concomitant with gliosis and impairment of tyrosine hydroxylase immunoreactivity in the rat substantia nigra Vol.4, No.3, p.151-158
Masami Ishido , Rumiko Usu
Released: June 30, 2017
Abstract Full Text PDF[1M]
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Original Article
No carcinogenicity of poly-trans-[(2-carboxyethyl) germasesquioxane] (Ge-132): 26-week feeding study using rasH2 mice Vol.4, No.3, p.137-150
Yuko Doi , Norio Imai , Mayuko Suguro , Takamasa Numano , Fumio Furukawa
Released: June 28, 2017
Abstract Full Text PDF[883K]
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Letter
The utility of human iPS cell-derived cardiomyocytes in predicting the clinical risk of drugs that display discordance of cardiotoxicity by species Vol.4, No.3, p.127-136
Nobuo Aikawa
Released: June 23, 2017
Abstract Full Text PDF[474K]
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Original Article
Utility of murine dendritic cell line DC2.4 for in vitro assay of skin-sensitization potential Vol.4, No.3, p.121-126
Erina Shiraishi , Akiko Ido , Youhei Hiromori , Kento Tanaka , Tomoki Kimura , Hisamitsu Nagase , Tsuyoshi Nakanishi
Released: June 09, 2017
Abstract Full Text PDF[766K]
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Letter
Permeability of skin to silver nanoparticles after epidermal skin barrier disruption in rats Vol.4, No.3, p.109-119
Makiko Kuwagata , Fumiaki Kumagai , Yoshiaki Saito , Kazuma Higashisaka , Yasuo Yoshioka , Yasuo Tsutsumi
Released: June 09, 2017
Abstract Full Text PDF[2M]
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Letter
A study for finding new phototoxicity descriptors related to potential energy Vol.4, No.3, p.105-107
Yu Haranosono , Shingo Nemoto , Masaaki Kurata , Hideyuki Sakaki
Released: June 02, 2017
Abstract Full Text PDF[359K]
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Letter
Phytocannabinoids, Δ9-tetrahydrocannabinol and cannabidiol, as human calpain-1 (CAPN1) activators Vol.4, No.2, p.101-103
Shuso Takeda , Kazuhito Watanabe , Hironori Aramaki
Released: May 13, 2017
Abstract Full Text PDF[248K]
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Original Article
Repeated-dose ocular instillation toxicity study: a survey of its study design on the basis of common technical documents in Japan Vol.4, No.2, p.95-99
Masaaki Kurata , Yoshinori Yamagiwa , Yu Haranosono , Hideyuki Sakaki
Released: May 13, 2017
Abstract Full Text PDF[1M]
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Original Article
Retraction: Quantitative morphometric analysis of vimentin filaments in Sertoli cells of rats after in utero DBP exposure
[Notice] Editor's Announcement was published on June 6, 2023		 Vol.4, No.2, p.85-93
Eisuke Kume , Yuya Okayama , Mituru Sugiyama , Hiroyuki Takahashi , Tomoko Muto , Michael F. Wempe , Hiroshi Ikegami , Shin Wakui
Released: May 13, 2017
Abstract Full Text PDF[3M]
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Toxicomics Report
Urinary proteome profile of renal papillary necrosis in experimental model rats Vol.4, No.2, p.77-83
Daisuke Sasaki , Masashi Hiramoto , Masatoshi Yuri , Kenjiro Tsubota , Hikaru Mitori , Akira Moriguchi , Akira Unami , Gi-Wook Hwang , Akira Naganuma
Released: April 14, 2017
Abstract Full Text PDF[410K]
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Original Article
Safety assessment of a soluble dietary fiber, isomaltodextrin, enzymatically produced from starch Vol.4, No.2, p.57-75
Tsuyoshi Sadakiyo , Shin-ichiro Inoue , Yuki Ishida , Hikaru Watanabe , Hitoshi Mitsuzumi , Shimpei Ushio
Released: March 25, 2017
Abstract Full Text PDF[344K]
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Original Article
Oral acute and chronic toxicity studies of β, β-dimethylacrylalkannin in mice and rats Vol.4, No.2, p.45-56
Piao-Piao Zhang , Xiao-Dan Yan , Xiao-Yu Fan , Ya-Hao Ling , Chao Li , Lin Lin , Dan Qin , Tian-Tian Liu , Ye Li , Hui Li , Qianqian Zhang , Wen-Bo Mu , Ai-Ping Wang , Hong-Tao Jin , Jin-Feng Wei
Released: March 17, 2017
Abstract Full Text PDF[4M]
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Letter
Small interfering RNA-mediated knockdown of the transcription factor TCF3 enhances sensitivity to methylmercury in mouse neural stem cells Vol.4, No.2, p.41-43
Tsutomu Takahashi , Yanjiao Wang , Takashi Toyama , Min-Seok Kim , Shusuke Kuge , Gi-Wook Hwang , Akira Naganuma
Released: March 07, 2017
Abstract Full Text PDF[874K]
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Toxicomics Report
Identification of transcription factors activated by methylmercury in mouse brain Vol.4, No.1, p.37-39
Min-Soek Kim , Tsutomu Takahashi , Jin-Yong Lee , Nobuhiko Miura , Masato Asanuma , Gi-Wook Hwang , Akira Naganuma
Released: February 24, 2017
Abstract Full Text PDF[329K]
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Toxicomics Report
Proteomic analysis of valproic acid-induced embryotoxicity in cultured post-implantation rat embryos Vol.4, No.1, p.31-35
Makoto Usami , Mina Takamatsu , Shugo Kazama , Katsuyoshi Mitsunaga , Atsuko Miyajima , Tomohiko Irie , Osamu Doi , Tatsuya Takizawa , Teruko Nagi , Momoko Sunouchi
Released: February 24, 2017
Abstract Full Text PDF[1M]
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Original Article
Application of a portable gas chromatograph for quantitative measurement of canine oral malodor Vol.4, No.1, p.23-29
Naoki Iwashita , Kazutoshi Sugita , Mitsuyuki Shirai , Sayaka Murata , Shiho Yanagisawa , Sumio Goto , Yukihiko Takagi , Fumitoshi Asai
Released: February 24, 2017
Abstract Full Text PDF[521K]
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Original Article
Normal ovarian aging, but modified T-cell differentiation, in female mice following neonatal exposure to bisphenol A Vol.4, No.1, p.15-21
Ryo Ohta , Hideo Ohmukai , Tsukasa Negura , Yoshiyuki Tazura , Omoko Shindo
Released: February 17, 2017
Abstract Full Text PDF[1M]
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Letter
Effects of oral administration of gelatin capsules on plasma insulin and glucagon levels in dogs Vol.4, No.1, p.9-14
Hideaki Yokoyama , Taku Masuyama , Tomio Ishida , Yusuke Suzuki , Toshiyuki Shoda , Hideyuki Kuno , Shoichiro Sugai
Released: February 08, 2017
Abstract Full Text PDF[377K]
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Original Article
Simultaneous depletion of WRNIP1 and RAD52 restores resistance to oxidative stress Vol.4, No.1, p.1-7
Akari Yoshimura , Haruna Yabe , Miho Akatani , Masayuki Seki , Takemi Enomoto
Released: January 27, 2017
Abstract Full Text PDF[1M]
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2016 - Vol. 3

Original Article
Streptozotocin-induced diabetic state triggers glucose-dependent insulinotropic polypeptide (GIP) expression in the rat liver Vol.3, No.6, p.291-296
Yuka Kohda , Chiaki Minamigawa , Mikako Matsuo , Hitoshi Matsumura
Released: December 24, 2016
Abstract Full Text PDF[694K]
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Original Article
Sensitivity of MT-III null mice upon chronic exposure to cadmium Vol.3, No.6, p.285-289
Jin-Yong Lee , Maki Tokumoto , Yasuyuki Fujiwara , Gi-Wook Hwang , Moo-Yeol Lee , Masahiko Satoh
Released: December 21, 2016
Abstract Full Text PDF[892K]
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Letter
Cadmium-induced protein ubiquitination in UBA80 knockdown HK-2 cells Vol.3, No.6, p.281-284
Jin-Yong Lee , Maki Tokumoto , Gi-Wook Hwang , Masahiko Satoh
Released: November 26, 2016
Abstract Full Text PDF[634K]
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Letter
DNA microarray analysis of fetal liver of C57BL/6J mice exposed to cadmium during gestation Vol.3, No.6, p.257-280
Hisaka Kurita , Hisamitsu Nagase , Maki Tokumoto , Jin-Yong Lee , Masahiko Satoh
Released: November 26, 2016
Abstract Full Text PDF[232K]
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Original Article
Validation of retrospective evaluation method for false genotoxic chemicals with strong cytotoxicity: re-evaluation using in vitro micronucleus test Vol.3, No.6, p.251-256
Yurika Fujita , Yuichi Ito , Osamu Morita , Hiroshi Honda
Released: November 25, 2016
Abstract Full Text PDF[294K]
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Letter
Safety assessment of probiotic bacteria, Bacillus coagulans strain SANK70258, in rats Vol.3, No.6, p.243-250
Yui Akagawa , Yasuyuki Ohnishi , Masatoshi Takaya , Yuko Watanabe
Released: October 19, 2016
Abstract Full Text PDF[283K]
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Letter
Combined effect of circadian dysfunction and cadmium on immune suppression Vol.3, No.5, p.237-242
Katsumi Ohtani , Atsushige Ashimori , Yukie Yanagiba , Hiroki Yoshioka , Tatsuya Hasegawa , Gi-Wook Hwang , Masayuki Ikeda , Nobuhiko Miura
Released: October 04, 2016
Abstract Full Text PDF[344K]
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Letter
Hepatoprotective effect of kampo formula “Juzen-taiho-to” on bromobenzene-induced toxicity in mice Vol.3, No.5, p.233-236
Hiroki Yoshioka , Shiori Fukaya , Nobuhiko Miura , Akito Nagatsu , Tsunemasa Nonogaki
Released: September 10, 2016
Abstract Full Text PDF[278K]
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Minireview
Ocular instillation toxicity study: current status and points to consider on study design and evaluation Vol.3, No.5, p.217-232
Masaaki Kurata , Ikuyo Atsumi , Yoshinori Yamagiwa , Hideyuki Sakaki
Released: August 18, 2016
Abstract Full Text PDF[285K]
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Original Article
In vitro and in vivo toxicological assessments of Antrodia cinnamomea health food product (Leader Antrodia cinnamomea Capsule) Vol.3, No.5, p.205-216
Yu-Hsing Lin , K.J. Senthil Kumar , M. Gokila Vani , Jiunn-Wang Liao , Chin-Chung Lin , Jong-Tar Kuo , Sheng-Yang Wang
Released: August 02, 2016
Abstract Full Text PDF[234K]
Supplemental Data
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Original Article
Acute toxicity of phorate oxon by oral gavage in the Sprague-Dawley rat Vol.3, No.5, p.195-204
Thomas H. Snider , Kevin G. McGarry , Michael C. Babin , David A. Jett , Gennady E. Platoff Jr. , David T. Yeung
Released: July 22, 2016
Abstract Full Text PDF[4M]
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Original Article
Neurobehavioral toxicity related to the exposure of weaning mice to low-level mercury vapor and methylmercury and influence of aging Vol.3, No.4, p.185-193
Minoru Yoshida , Jin-Yong Lee , Hana Shimizu-Furusawa , Masahiko Satoh , Chiho Watanabe
Released: June 17, 2016
Abstract Full Text PDF[1M]
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Original Article
Estimation of occupational exposure to drugs during tablet crushing Vol.3, No.4, p.177-183
Shizuko Maeda , Eiko Takahashi , Yoshitaka Tayama , Shigeyuki Kitamura , Toyohisa Tsukamoto , Katsushi Miyake , Kazumi Sugihara
Released: June 15, 2016
Abstract Full Text PDF[873K]
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Original Article
The in vivo Pig-a gene mutation assay is applied to study the genotoxicity of procarbazine hydrochloride in Sprague-Dawley rats Vol.3, No.4, p.167-175
Jiang Pu , Yuanyuan Deng , Xiaoyan Tan , Gaofeng Chen , Cong Zhu , Naisong Qi , Hairuo Wen , Jun Guo , Xin Wang , Yuwen Qiu , Jinqiang Liang , Xinlu Fu , Yanping Hu , Jie Song , Xingchao Geng , Chao Wang , Lin Zhang , Zhiying Huang , Bo Li , Xue Wang
Released: May 31, 2016
Abstract Full Text PDF[2M]
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Original Article
A high-throughput Bhas 42 cell transformation assay for the determination of the carcinogenicity of three herbal extracts Vol.3, No.4, p.157-166
Jiang Pu , Ying Wang , Naisong Qi , Wenwan Du , Xiaoyan Tan , Gaofeng Chen , Hairuo Wen , Xin Wang , Yanping Hu , Jie Song , Yuwen Qiu , Jinqiang Liang , Xinlu Fu , Zhiying Huang , Xue Wang
Released: May 31, 2016
Abstract Full Text PDF[2M]
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Original Article
Zinc sulfate pretreatment prevents carbon tetrachloride-induced lethal toxicity through metallothionein-mediated suppression of lipid peroxidation in mice Vol.3, No.4, p.151-156
Hiroki Yoshioka , Satomi Onosaka
Released: May 24, 2016
Abstract Full Text PDF[351K]
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Original Article
Peroxisome proliferator activated receptor-mediated genotoxicity of perfluoroalkyl acids using human lymphoblastoid cells Vol.3, No.4, p.143-150
Maki Nakamura , Tomomi Takahashi , Takuya Izumi , Masanori Miura , Satomi Kawaguchi , Ayumi Yamamoto , Shuji Tsuda , Takanori Nakamura , Shuhei Tanaka , Naoto Shimizu , Yu F. Sasaki
Released: May 20, 2016
Abstract Full Text PDF[1M]
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Original Article
GCN5-deficiency remarkably enhances the sensitivity of B cells in response to 4-nitroquinoline 1-oxide Vol.3, No.3, p.137-142
Hidehiko Kikuchi , Futoshi Kuribayashi , Hitomi Mimuro , Shinobu Imajoh-Ohmi
Released: May 17, 2016
Abstract Full Text PDF[451K]
Supplemental Data
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Letter
Acute hepatotoxicity induced by quetiapine fumarate in larval zebrafish Vol.3, No.3, p.127-135
Jinfeng Liang , Wangdong Jin , Haibin Wei , Hongwen Li , Fei Jia , Jing Qian , Hongcui Liu , Yanfeng Huang , Chunqi Li , Li Zhou , Thomas Efferth
Released: May 11, 2016
Abstract Full Text PDF[2M]
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Letter
Methyl cinnamate increases cell vulnerability to oxidative stress induced by hydrogen peroxide in rat thymocytes Vol.3, No.3, p.121-125
Hiromitsu Tsuzuki , Shota Inoue , Daiki Kobayashi , Gantulga Uuganbaatar , Kaori Kanemaru , Kumio Yokoigawa , Yasuo Oyama
Released: May 11, 2016
Abstract Full Text PDF[1M]
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Letter
Possible involvement of FosB in (–)-xanthatin-mediated anti-proliferative effects in human cancer MDA-MB-231 cells Vol.3, No.3, p.115-119
Shuso Takeda , Shunsuke Okajima , Momoko Noguchi , Hiroko Miyoshi , Kuniyoshi Koyachi , Kenji Matsumoto , Mitsuru Shindo , Hironori Aramaki
Released: May 11, 2016
Abstract Full Text PDF[287K]
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Letter
Cytotoxicity of zinc, copper and rhodium complexes with 1,10-phenanthroline or 2,9-dimethyl-1,10-phenanthroline in cultured vascular endothelial cells Vol.3, No.3, p.109-113
Takato Hara , Hiroka Matsuzaki , Takehiro Nakamura , Eiko Yoshida , Takanori Ohkubo , Hiroki Maruyama , Chika Yamamoto , Shinichi Saito , Toshiyuki Kaji
Released: May 11, 2016
Abstract Full Text PDF[3M]
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Original Article
Major histocompatibility complex expression in a rotenone model of Parkinson’s disease in rats Vol.3, No.3, p.101-108
Masami Ishido , Eiko Shimaya
Released: April 20, 2016
Abstract Full Text PDF[2M]
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Letter
Requirements for human iPS cell-derived hepatocytes as an alternative to primary human hepatocytes for assessing absorption, distribution, metabolism, excretion and toxicity of pharmaceuticals Vol.3, No.3, p.89-99
Tetsuro Araki , Norihiko Iwazaki , Naoki Ishiguro , Atsushi Sakamoto , Keisuke Nagata , Masato Ohbuchi , Hiroyuki Moriguchi , Makiko Motoi , Raku Shinkyo , Toshiki Homma , Sakae Sakamoto , Yumiko Iwase , Ryota Ise , Yasuharu Nakanishi , Masahiro Uto , Tomoaki Inoue
Released: April 05, 2016
Abstract Full Text PDF[1M]
Supplemental Data
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Original Article
Comparative study of the zebrafish embryonic toxicity test and mouse embryonic stem cell test to screen developmental toxicity of human pharmaceutical drugs Vol.3, No.2, p.79-87
Atsuto Inoue , Yuhei Nishimura , Norihito Matsumoto , Noriko Umemoto , Yasuhito Shimada , Toru Maruyama , Kana Kayasuga , Motohiko Morihara , Jun Katagi , Tsutomu Shiroya , Yasushi Hirota , Soonih Kim , Toshio Tanaka
Released: March 26, 2016
Abstract Full Text PDF[2M]
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Toxicomics Report
Overexpression of palmitoyl transferase HIP14 confers resistance to methylmercury in SH-SY5Y human neuroblastoma cells Vol.3, No.2, p.75-77
Yousuke Ogiwara , Nobuhiko Miura , Shusuke Kuge , Akira Naganuma , Gi-Wook Hwang
Released: March 26, 2016
Abstract Full Text PDF[196K]
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Original Article
Prenatal exposure to rutile-type alumina-coated titanium dioxide nanoparticles impairs mouse spermatogenesis Vol.3, No.2, p.67-74
Miyoko Kubo-Irie , Yusuke Shinkai , Shotaro Matsuzawa , Hiroki Uchida , Kenichiro Suzuki , Rikio Niki , Shigeru Oshio , Ken Takeda
Released: March 17, 2016
Abstract Full Text PDF[4M]
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Toxicomics Report
Transcription factor activation in rat primary astrocytes exposed to methylmercury Vol.3, No.2, p.63-65
Takuya Takemoto , Yasuhiro Ishihara , Mayumi Tsuji , Toshihiro Kawamoto , Takeshi Yamazaki
Released: March 04, 2016
Abstract Full Text PDF[169K]
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Letter
HU-210, a synthetic analog of Δ9-THC, is not a modifier of estrogen signaling in MCF-7 human breast cancer cells Vol.3, No.2, p.55-61
Hiroyuki Okazaki , Shuso Takeda , Hiroyuki Ishii , Saki Matsuo , Erika Furuta , Kazuhito Watanabe , Hironori Aramaki
Released: March 03, 2016
Abstract Full Text PDF[389K]
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Letter
Differing responses of human stem cell-derived cardiomyocytes to arrhythmogenic drugs, determined using impedance measurements Vol.3, No.2, p.47-53
Arisa Higa , Hirotaka Hoshi , Motoki Takagi
Released: February 26, 2016
Abstract Full Text PDF[2M]
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Original Article
Toxicogenomic prediction with graph-based structured regularization on transcription factor network Vol.3, No.2, p.39-46
Keisuke Nagata , Yoshinobu Kawahara , Takashi Washio , Akira Unami
Released: February 26, 2016
Abstract Full Text PDF[888K]
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Letter
Fipronil, an insecticide, acts as an anti-estrogen via the concomitant down-regulation of ERα and PES1 Vol.3, No.1, p.33-37
Hiroyuki Okazaki , Eriko Kohro-Ikeda , Shuso Takeda , Hiroyuki Ishii , Erika Furuta , Saki Matsuo , Masaya Matsumoto , Masufumi Takiguchi , Hironori Aramaki
Released: February 23, 2016
Abstract Full Text PDF[295K]
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Letter
Quantitative analysis of the relationship between the LLNA:DAE method results and the LLNA EC3 values highlights the connection between the elicitation and induction phases during skin sensitization Vol.3, No.1, p.27-31
Kunihiko Yamashita , Shinsuke Shinoda , Saori Hagiwara , Hiroshi Itagaki
Released: February 03, 2016
Abstract Full Text PDF[232K]
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Original Article
A study on the influence of acotiamide hydrochloride hydrate on sex hormones, using a uterotrophic bioassay in rat Vol.3, No.1, p.19-25
Hiroyuki Kuroda , Takashi Yamaguchi , Toshiko Kinomoto , Shuji Ogawa , Hitoshi Naraoka , Kazuhiko Takamatsu , Yuji Oishi
Released: January 26, 2016
Abstract Full Text PDF[1M]
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Original Article
Hepatitis C virus core can induce lipid droplet formation in a yeast model system Vol.3, No.1, p.13-18
Shingo Iwasa , Naoko Satoh , Hayato Irokawa , Junichi Kikuchi , Jun Okawa , Masataka Nomoto , Gi-Wook Hwang , Akira Naganuma , Shusuke Kuge
Released: January 13, 2016
Abstract Full Text PDF[902K]
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Letter
Single dose oral toxicity study of Picrorhiza kurroa rhizome extract in Wistar rats Vol.3, No.1, p.9-12
Acharya Bal Krishna , Hemanth Kumar Manikyam , Vinay K Sharma , Niti Sharma
Released: January 13, 2016
Abstract Full Text PDF[226K]
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Letter
Physiological conditions in iPRECIO® -implanted rats Vol.3, No.1, p.1-8
Masaru Tsuboi , Yoshihide Ueda , Yasufumi Ota , Hiroshi Takehara , Takuya Aoshima , Fukutaro Mizuhashi
Released: January 09, 2016
Abstract Full Text PDF[471K]
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2015 - Vol. 2

Toxicomics Report
The enhancement effect of HIST1H4C knockdown on cadmium toxicity in human proximal tubular cells Vol.2, No.6, p.259-262
Jin-Yong Lee , Maki Tokumoto , Masahiko Satoh
Released: December 22, 2015
Abstract Full Text PDF[274K]
Page Top
Original Article
Developmental changes in associative learning behavior in male rats Vol.2, No.6, p.249-258
Rieko Hojo , Yukie Yanagiba , Megumi Suda , Masao Tsuchiya
Released: December 22, 2015
Abstract Full Text PDF[380K]
Page Top
Toxicomics Report
Knockdown of Acyl-CoA thioesterase 9 gene expression by siRNA confers resistance to arsenite in HEK293 cells Vol.2, No.6, p.245-247
Tsutomu Takahashi , Min-Seok Kim , Gi-Wook Hwang , Shusuke Kuge , Akira Naganuma
Released: December 21, 2015
Abstract Full Text PDF[295K]
Page Top
Letter
Methylmercury induces expression of interleukin-1β and interleukin-19 in mice brains Vol.2, No.6, p.239-243
Tsutomu Takahashi , Miyuki Iwai-Shimada , Yukina Syakushi , Min-Seok Kim , Gi-Wook Hwang , Nobuhiko Miura , Akira Naganuma
Released: December 21, 2015
Abstract Full Text PDF[471K]
Page Top
Letter
(–)-Xanthatin-mediated marked up-regulation of RhoB, a sensor for damaged DNA Vol.2, No.6, p.233-238
Shuso Takeda , Shunsuke Okajima , Hiroko Miyoshi , Kuniyoshi Koyachi , Kenji Matsumoto , Mitsuru Shindo , Hironori Aramaki
Released: December 12, 2015
Abstract Full Text PDF[396K]
Page Top
Letter
Citrulline enhances methylmercury toxicity in HEK293 and C17.2 cells Vol.2, No.6, p.229-231
Takashi Toyama , Gi-Wook Hwang , Akira Naganuma
Released: December 11, 2015
Abstract Full Text PDF[530K]
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Toxicomics Report
Metabolomic analysis of low molecular weight substances released into medium from HEK293 cells treated with methylmercury Vol.2, No.5, p.227-228
Takashi Toyama , Gi-Wook Hwang , Akira Naganuma
Released: December 09, 2015
Abstract Full Text PDF[158K]
Page Top
Original Article
Methylmercury induces release of a cytotoxic factor from HEK293 cells into medium Vol.2, No.5, p.223-226
Takashi Toyama , Souichi Murakami , Shusuke Kuge , Gi-Wook Hwang , Akira Naganuma
Released: December 02, 2015
Abstract Full Text PDF[988K]
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Letter
Cytotoxic actions of N-(2,4,6-trichlorophenyl)maleimide (IT-354), an antifouling agent, in rat thymic lymphocytes Vol.2, No.5, p.217-222
Eri Fukunaga , Shohei Saito , Yuya Kurumi , Yurie Ohiwa , Eri Kurozumi , Yasuo Oyama
Released: November 26, 2015
Abstract Full Text PDF[1M]
Page Top
Original Article
Zn2+-dependent increase in cells with phosphatidylserine-exposed membranes after treatment with submicromolar concentrations of 2-n-octyl-4-isothiazolin-3-one in rat thymocytes Vol.2, No.5, p.209-216
Eri Fukunaga , Sari Honda , Yuji Hashimoto , Yasuaki Tamura , Shiro Ishida , Yasuo Oyama
Released: November 16, 2015
Abstract Full Text PDF[1M]
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Original Article
Bioconcentration of perfluorinated compounds in wild medaka is related to octanol/water partition coefficient Vol.2, No.5, p.201-208
Katsumi Iwabuchi , Norimasa Senzaki , Shuji Tsuda , Haruna Watanabe , Ikumi Tamura , Hitomi Takanobu , Norihisa Tatarazako
Released: October 27, 2015
Abstract Full Text PDF[673K]
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Original Article
A repeated dose 28-day oral toxicity study of β-bromostyrene in rats Vol.2, No.4, p.191-200
Atsushi Ono , Katsumi Kobayashi , Hideki Serizawa , Tomoko Kawamura , Hina Kato , Mariko Matsumoto , Mika Takahashi , Mutsuko Hirata-Koizumi , Yuko Matsushima , Akihiko Hirose
Released: September 29, 2015
Abstract Full Text PDF[202K]
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Original Article
Repeated dose and reproductive/developmental toxicity of long-chain perfluoroalkyl carboxylic acids in rats: perfluorohexadecanoic acid and perfluorotetradecanoic acid Vol.2, No.4, p.177-190
Mutsuko Hirata-Koizumi , Sakiko Fujii , Kato Hina , Mariko Matsumoto , Mika Takahashi , Atsushi Ono , Akihiko Hirose
Released: September 28, 2015
Abstract Full Text PDF[369K]
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Letter
Health survey of workers in a 2,4,6-trinitrotoluene explosives factory in Fuxin, China Vol.2, No.4, p.171-175
Yasuhiro Shinkai , Song Li , Tomohiro Kikuchi , Nobuhiro Shimojo , Yoshito Kumagai
Released: September 15, 2015
Abstract Full Text PDF[172K]
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Original Article
Toxicogenomic prediction with group sparse regularization based on transcription factor network information Vol.2, No.4, p.161-170
Keisuke Nagata , Yoshinobu Kawahara , Takashi Washio , Akira Unami
Released: September 15, 2015
Abstract Full Text PDF[1M]
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Letter
Effects of rofecoxib on lipid oxidation in plasma and aortas of rats Vol.2, No.4, p.155-159
Atsushi Miyajima , Yasuha Amano , Takeyoshi Kamamoto , Masahiro Okamoto , Takashi Hirota
Released: September 07, 2015
Abstract Full Text PDF[243K]
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Letter
In vitro comet assay in cultured human corneal epithelial cells Vol.2, No.4, p.147-153
Hideyuki Sakaki , Masaki Kakehi , Kazuyo Sadamoto , Shingo Nemoto , Masaaki Kurata
Released: September 04, 2015
Abstract Full Text PDF[1M]
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Original Article
Effects of cisplatin on testicular enzymes and Sertoli cell function in rats Vol.2, No.4, p.137-145
Zhifei Liu , Yingbiao Sun , Li Su , Yifan Sun , Shibo Kong , Xuhong Chang , Fang Guo , Wei Li , Junjie Guo , Jin Li
Released: August 25, 2015
Abstract Full Text PDF[1M]
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Original Article
Effects of dietary fish oil on cytochrome P450 3A expression in the liver of SHR/NDmcr-cp (cp/cp) rats, an animal model for metabolic syndrome Vol.2, No.3, p.127-135
Tohru Yamazaki , Takashi Ohki , Hiroki Taguchi , Asami Yamamoto , Mari Okazaki , Takeshi Sakamoto , Atsushi Mitsumoto , Yoichi Kawashima , Naomi Kudo
Released: August 05, 2015
Abstract Full Text PDF[347K]
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Original Article
The concern for uterine carcinogenesis in safety assessments for a new pharmaceutical Vol.2, No.3, p.117-126
Hiroyuki Kuroda , Takashi Yamaguchi , Toshiko Kinomoto , Shuji Ogawa , Atsushi Shiga , Hitoshi Naraoka , Kazuhiko Takamatsu , Yuji Oishi
Released: July 30, 2015
Abstract Full Text PDF[2M]
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Letter
Evaluation of laser irradiance on photodynamic therapy using talaporfin sodium-induced glioblastoma T98G cell death Vol.2, No.3, p.111-116
Yuichi Miki , Jiro Akimoto , Aya Sato , Yasuyuki Fujiwara
Released: June 26, 2015
Abstract Full Text PDF[2M]
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Letter
Positive and negative ions by air purifier have no effects on reproductive function or postnatal growth and development in rats Vol.2, No.3, p.101-110
Dai Yamamoto , Yumi Wako , Shino Kumabe , Kiyoshi Wako , Yukari Sato , Mayumi Fujishiro , Yoshimasa Yasuda , Ikuo Matsuura , Yasuyuki Ohnishi
Released: June 23, 2015
Abstract Full Text PDF[181K]
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Original Article
Metabolism of trimethylselenonium ion in selenium accumulator, Allium sativum Vol.2, No.3, p.95-99
Yasumitsu Ogra , Yurie Ogihara , Yasumi Anan
Released: June 16, 2015
Abstract Full Text PDF[379K]
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Toxicomics Report
DNA microarray analysis of genes in highly metastatic 4T1E/M3 murine breast cancer cells following exposure to cannabidiolic acid Vol.2, No.2, p.89-94
Shuso Takeda , Hiroyuki Okazaki , Eriko Kohro-Ikeda , Kazutaka Yoshida , Miki Tokuyasu , Yukimi Takemoto , Ramu Mizunoe , Sawa Tanaka , Tomoko Okada , Hironori Aramaki
Released: June 01, 2015
Abstract Full Text PDF[524K]
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Original Article
Measurement of oral bacterial counts in dogs by dielectrophoretic impedance Vol.2, No.2, p.83-87
Soraaki Takahashi , Motoi Kuratani , Maho Tanaka , Tetsuro Ito , Nobuyuki Kanemaki , Mitsuyuki Shirai , Ryota Nomura , Kazuhiko Nakano , Fumitoshi Asai
Released: May 27, 2015
Abstract Full Text PDF[221K]
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Letter
Motor activities of newborns prenatally exposed to low-dose bisphenol A in diverse mouse strains Vol.2, No.2, p.79-82
Nao Kagawa , Munekazu Komada , Tetsuji Nagao
Released: May 27, 2015
Abstract Full Text PDF[238K]
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Original Article
Effect of prenatal methylmercury exposure on neurobehavioral development in male mice: comparison between methylmercury in fish and methylmercury chloride added to diets Vol.2, No.2, p.67-78
Miyuki Iwai-Shimada , Michiaki Yamashita , Naoyuki Kurokawa , Kunihiko Nakai , Mitsuharu Ishida , Akira Naganuma , Hiroshi Satoh
Released: April 03, 2015
Abstract Full Text PDF[481K]
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Letter
Comparative cytotoxicity of triphenylstibane and fluorine-substituted triarylpnictogens in cultured vascular endothelial cells Vol.2, No.2, p.61-66
Masaki Murakami , Tomoya Fujie , Mio Matsumura , Eiko Yoshida , Chika Yamamoto , Yasuyuki Fujiwara , Shuji Yasuike , Toshiyuki Kaji
Released: March 28, 2015
Abstract Full Text PDF[1M]
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Original Article
Metabolic fate of excessive glucose in fibroblast cells in a diabetic setting Vol.2, No.2, p.55-60
Yuka Kohda , Kazuma Iwatate , Takao Tanaka , Hitoshi Matsumura
Released: February 20, 2015
Abstract Full Text PDF[327K]
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Letter
Comparison of cytotoxicity among pectenotoxin-2 and other oxidized pectenotoxins in a rat myoblast cell line (L6) and a human rhabdomyosarcoma cell line (RD) Vol.2, No.1, p.49-54
Ryoji Matsushima , Saori Kikutsugi , Ryuichi Watanabe , Hajime Uchida , Takeshi Yasumoto , Hiroshi Nagai , Masaki Kaneniwa , Toshiyuki Suzuki
Released: February 03, 2015
Abstract Full Text PDF[1M]
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Original Article
Utility of human hepatocyte spheroids for evaluation of hepatotoxicity Vol.2, No.1, p.41-48
Takuo Ogihara , Hisakazu Iwai , Yukiko Inoue , Jun Katagi , Norihito Matsumoto , Makiko Motoi-Ohtsuji , Motoharu Kakiki , Shinya Kaneda , Takuya Nagao , Kumiko Kusumoto , Emiko Ozeki , Tomoko Jomura , Sho Tanaka , Tadayoshi Ueda , Kunihiro Ohta , Takako Ohkura , Hiroshi Arakawa , Daichi Nagai
Released: January 21, 2015
Abstract Full Text PDF[489K]
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Letter
Effects of prenatal exposure to low doses of diethylstilbestrol on motor activity in newborn mice Vol.2, No.1, p.37-39
Kaho Ozaki , Nao Kagawa , Munekazu Komada , Tetsuji Nagao
Released: January 16, 2015
Abstract Full Text PDF[200K]
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Original Article
Impact of different blood sampling techniques on plasma biomarkers for skeletal myopathy in conscious rats Vol.2, No.1, p.25-36
Kyoko Miwa , Satoshi Tamai , Yasuhiro Kinpara , Satomi Komatsu , Mayumi Goto , Takuma Iguchi , Takami Suzuki , Wataru Takasaki , Kazuhiko Mori
Released: January 16, 2015
Abstract Full Text PDF[955K]
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Letter
Silica nanoparticle-induced toxicity in mouse lung and liver imaged by electron microscopy Vol.2, No.1, p.19-23
Katsuhiro Isoda , Masuo Kondoh , Yasuo Yoshioka , Yasuo Tsutsumi , Takayoshi Imazawa , Tetsuji Nishimura , Isao Ishida , Kiyohito Yagi
Released: January 16, 2015
Abstract Full Text PDF[3M]
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Original Article
Effects of sub-chronic exposure to deltamethrin on shuttle-box avoidance and contents of amino acid neurotransmitters in hippocampus of mice Vol.2, No.1, p.9-17
Cao Pei , Ma Ning , Gao Peng , Feng Yong-quan , Wang Xiao-dan , Xu Hai-bin
Released: January 13, 2015
Abstract Full Text PDF[1M]
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Original Article
Effect of nanoparticles injected into larvae on spermatogenesis in the pupal testis of the sweet potato hornworm, Agrius convolvuli (L.) Vol.2, No.1, p.1-8
Miyoko Kubo-Irie , Masami Shimoda , Azumi Sato , Kyhota Shida , Terumi Yamaguchi , Hideo Mohri , Ken Takeda , Masaru Irie
Released: January 13, 2015
Abstract Full Text PDF[3M]
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2014 - Vol. 1

Letter
Estimation of endoplasmic reticulum stress-inducing ability of nobiletin, a citrus polymethoxyflavonoid, in SK-N-SH human neuroblastoma cells Vol.1, No.4, p.169-172
Ayaka Ikeda , Shingo Miyata , Akihito Yokosuka , Yoshihiro Mimaki , Yasushi Ohizumi , Masakuni Degawa , Kiyomitsu Nemoto
Released: December 25, 2014
Abstract Full Text PDF[363K]
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Toxicomics Report
The involvement of GPRC5B in cadmium toxicity in HK-2 cells Vol.1, No.4, p.165-167
Jin-Yong Lee , Maki Tokumoto , Yasuyuki Fujiwara , Moo-Yeol Lee , Masahiko Satoh
Released: December 25, 2014
Abstract Full Text PDF[754K]
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Toxicomics Report
CDC23 knockdown reinforces methylmercury sensitivity in HEK293 cells Vol.1, No.4, p.161-164
Ke Du , Tsutomu Takahashi , Miyuki Iwai-Shimada , Nobuhiko Miura , Akira Naganuma , Gi-Wook Hwang
Released: December 24, 2014
Abstract Full Text PDF[1M]
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Original Article
Safety evaluation of mutagenecity, acute and subacute toxicity study of Chlorella vulgaris CK-22 in rats Vol.1, No.4, p.151-159
Sayaka Himuro , Sugi Ueno , Naoto Noguchi , Takuya Uchikawa , Koji Watanabe
Released: December 22, 2014
Abstract Full Text PDF[333K]
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Original Article
Apoptotic activities of the extract from Moringa oleifera leaves on human HCT116 colon cancer cells Vol.1, No.4, p.143-149
Jintana Tragulpakseerojn , Ryuzaburo Yuki , Takuya Honda , Mariko Morii , Auayporn Apirakaramwong , Noritaka Yamaguchi , Perayot Pamonsinlapatham , Naoto Yamaguchi
Released: December 16, 2014
Abstract Full Text PDF[664K]
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Letter
Effects of a repeated low dose of LiCl injection under conditioned taste/flavor aversion using xylene Vol.1, No.4, p.135-142
Rieko Hojo , Mitsutoshi Takaya , Yukie Yanagiba , Akinori Yasuda , Masao Tsuchiya , Yasutaka Ogawa
Released: December 08, 2014
Abstract Full Text PDF[276K]
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Toxicomics Report
Effects of cadmium on the gene expression of SLC39A1 coding for ZIP1 protein Vol.1, No.4, p.131-133
Jin-Yong Lee , Maki Tokumoto , Yasuyuki Fujiwara , Moo-Yeol Lee , Masahiko Satoh
Released: December 04, 2014
Abstract Full Text PDF[413K]
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Original Article
The paradoxical effect of 1,4-naphthoquinone on the process of cell death induced by hydrogen peroxide in rat thymocytes Vol.1, No.4, p.123-129
Hana Ohtani , Eri Fukunaga , Yasuo Oyama , Shiro Ishida , Norio Akaike
Released: November 21, 2014
Abstract Full Text PDF[937K]
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Original Article
Diallyl disulfide administration increases the number of B-lymphocytes in the rat spleen Vol.1, No.4, p.115-121
Yoko Hashizume , Ken Shirato , Kaoru Tachiyashiki , Kazuhiko Imaizumi
Released: November 19, 2014
Abstract Full Text PDF[395K]
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Toxicomics Report
Identification of growth-dependent genes involved in paraquat toxicity in Saccharomyces cerevisiae Vol.1, No.3, p.113-114
Tsutomu Takahashi , JunXuan Zhu , Naoya Sonoda , Shusuke Kuge , Gi-Wook Hwang , Akira Naganuma
Released: November 10, 2014
Abstract Full Text PDF[379K]
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Toxicomics Report
Overexpression of RPN8, SKP1, MIA40 or MES1 increases resistance to cadmium in Saccharomyces cerevisiae Vol.1, No.3, p.109-111
Tsutomu Takahashi , JunXuan Zhu , Shusuke Kuge , Gi-Wook Hwang , Akira Naganuma
Released: November 10, 2014
Abstract Full Text PDF[301K]
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Original Article
Sex-dependent difference in the hepatic and pulmonary toxicological effects in mice administrated 7-chlorinated benz[a]anthracene Vol.1, No.3, p.101-108
Hiroyuki Sakakibara , Takashi Ohura , Yuta Kamiya , Noriko Yamanaka , Nobuaki Shimada , Kayoko Shimoi , Keerthi S. Guruge
Released: November 10, 2014
Abstract Full Text PDF[288K]
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Original Article
A screening method for growth-dependent genes involved in the cytotoxicity of chemicals in Saccharomyces cerevisiae Vol.1, No.3, p.95-99
JunXuan Zhu , Tsutomu Takahashi , Shusuke Kuge , Gi-Wook Hwang , Akira Naganuma
Released: November 06, 2014
Abstract Full Text PDF[387K]
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Original Article
Residual metals in carbon nanotubes suppress the proliferation of neural stem cells Vol.1, No.3, p.87-94
Yukari Shigemoto-Mogami , Koki Fujimori , Yoshiaki Ikarashi , Akihiko Hirose , Yuko Sekino , Kaoru Sato
Released: November 06, 2014
Abstract Full Text PDF[236K]
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Letter
Hazardous effects of titanium dioxide nanoparticles on testicular function in mice Vol.1, No.3, p.81-85
Nobuhiko Miura , Katsumi Ohtani , Tatsuya Hasegawa , Rieko Hojo , Yukie Yanagiba , Tetsuya Suzuki , Megumi Suda , Rui-Sheng Wang
Released: October 28, 2014
Abstract Full Text PDF[218K]
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Original Article
Effects of organic and inorganic mercury(II) on gene expression via DNA conformational changes Vol.1, No.2, p.73-79
Koji Ueda , Rena Makino , Takao Tobe , Yoshinori Okamoto , Nakao Kojima
Released: October 23, 2014
Abstract Full Text PDF[593K]
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Original Article
A 4-week oral toxicity study of L-alanine in rats with a recovery period of 2 weeks Vol.1, No.2, p.63-72
Mami Aoki , Masahiro Mochizuki , Toshiya Okamura , Kazuhisa Hatayama , Atsushi Nakamura , Koji Morishita
Released: October 23, 2014
Abstract Full Text PDF[206K]
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Original Article
A 13-week feeding toxicity study of L-threonine in rats with a recovery period of 5 weeks Vol.1, No.2, p.49-62
Mami Aoki , Shigeru Ishida , Hideki Fukuzumi , Koji Morishita
Released: October 23, 2014
Abstract Full Text PDF[104K]
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Original Article
Safety evaluation of morphological changes in corneal endothelial cells induced by K-115 in cynomolgus monkeys Vol.1, No.2, p.39-47
Eiji Wato , Kozo Omichi , Shigeki Yoneyama , Mamoru Tanaka , Masataka Kagawa , Yukinori Amano
Released: October 15, 2014
Abstract Full Text PDF[416K]
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Original Article
28-Day dietary toxicity study of L-phenylalanine in rats Vol.1, No.2, p.29-38
Yusuke Shibui , Tadashi Miwa , Terutaka Kodama , Akinori Gonsho
Released: September 27, 2014
Abstract Full Text PDF[100K]
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Original Article
Nonclinical safety assessment for the sensitizing potential of K-115 Vol.1, No.1, p.19-27
Kozo Omichi , Eiji Wato , Yoshiki Kaneko , Shigeki Yoneyama , Akitaka Matsuda , Mikio Sasaki , Adrian Bull , David Coleman , Masataka Kagawa , Yukinori Amano
Released: September 04, 2014
Abstract Full Text PDF[109K]
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Original Article
Cytotoxic activity and abdominal writhes promoted by snake venom from Philodryas nattereri Steindachner, 1870 Vol.1, No.1, p.15-18
Marinetes Dantas de Aquino Nery , Hermano Damasceno de Aquino , Rayane de Tasso Moreira Ribeiro , Erik de Aquino Nery , Thiala Soares Josino da Silva , Rodrigo Tavares Dantas , Ramon Róseo Paula Pessoa Bezerra de Menezes , Marcus Felipe Bezerra da Costa , Alice Maria Costa Martins , Natacha Teresa Queiroz Alves , Helena Serra Azul Monteiro
Released: September 04, 2014
Abstract Full Text PDF[115K]
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Original Article
Edematogenic and myotoxic activities induced by snake venom of Philodryas nattereri from the Northeast of Brazil Vol.1, No.1, p.7-13
Marinetes Dantas de Aquino Nery , Hermano Damasceno de Aquino , Rayane de Tasso Moreira Ribeiro , Erik de Aquino Nery , Dalgimar Beserra de Menezes , Rafael Matos Ximenes , Arislete Dantas de Aquino , Lia Belchior Mendes Bezerra , Natacha Teresa Queiroz Alves , Helena Serra Azul Monteiro
Released: September 04, 2014
Abstract Full Text PDF[1M]
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Letter
Investigation of organ-specific assessment factors related to sub-acute and sub-chronic toxicity studies Vol.1, No.1, p.1-6
Jun-ichi Takeshita , Atsuo Kishimoto , Masashi Gamo
Released: August 06, 2014
Abstract Full Text PDF[95K]
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(C) 2014 Fundamental Toxicological Sciences.