Fundamental Toxicological Sciences

All Manuscripts

2018 - Vol. 5

Original Article
Increased hepatic triglyceride level induced by a glucokinase activator in mice Vol.5, No.1, p.13-20
Junichi Namekawa , Mari Yasui , Atsuko Katayanagi , Mitsuyuki Shirai , Fumitoshi Asai
Released: February 06, 2018
Abstract Full Text PDF[1M]
Original Article
A 28-day repeated oral-dose toxicity study of insecticide synergist N-(2-ethylhexyl)-1-isopropyl-4-methylbicyclo[2.2.2] oct-5-ene-2,3-dicarboximide in rats Vol.5, No.1, p.1-11
Mariko Matsumoto , Masatoshi Furukawa , Katsumi Kobayashi , Takako Iso , Toshime Igarashi , Takashi Yamada , Akihiko Hirose
Released: January 19, 2018
Abstract Full Text PDF[254K]

2017 - Vol. 4

Original Article
General toxicity of a vitamin K1 2,3-epoxide reductase (VKOR) inhibitor, 3-acetyl-5-methyltetronic acid, in rats Vol.4, No.6, p.285-293
Masashi Uchida , Yuka Sakaguchi , Yohei Miyamoto
Released: December 26, 2017
Abstract Full Text PDF[597K]
Original Article
Hepatic glucose-dependent insulinotropic polypeptide expression is modified by supplementing high-dose thiamine in obese diabetic rats Vol.4, No.6, p.279-284
Yuka Kohda , Akie Maekita , Takao Tanaka , Hitoshi Matsumura
Released: December 21, 2017
Abstract Full Text PDF[1M]
Letter
Effect of chronic cadmium exposure on the gene expression of Birc family in the mouse kidney and liver Vol.4, No.6, p.275-278
Jin-Yong Lee , Maki Tokumoto , Gi-Wook Hwang , Masahiko Satoh
Released: December 21, 2017
Abstract Full Text PDF[1M]
Original Article
Effect of metallothionein on ethanol-induced hepatotoxicity in mice Vol.4, No.6, p.269-273
Maki Tokumoto , Kiyoshi Shibuya , Jin-Yong Lee , Chiharu Tohyama , Masahiko Satoh
Released: December 15, 2017
Abstract Full Text PDF[1M]
Original Article
Suppressive effect of Sasa veitchii extract on obesity induced by a high-fat diet through modulation of adipose differentiation in mice Vol.4, No.6, p.261-268
Hiroki Yoshioka , Mihoko Mori , Masae Yoshikawa , Hirohisa Fujii , Akito Nagatsu , Tsunemasa Nonogaki
Released: December 13, 2017
Abstract Full Text PDF[1M]
Original Article
Toxicity of repeated 28-day oral administration of acenaphthylene in rats Vol.4, No.6, p.247-259
Shihori Tanabe , Katsumi Kobayashi , Mariko Matsumoto , Hideki Serizawa , Toshime Igarashi , Takashi Yamada , Akihiko Hirose
Released: November 07, 2017
Abstract Full Text PDF[219K]
Letter
In vitro genotoxicity test package of antibiotics for human use submitted to the Japanese regulatory agency during 2004–2015 Vol.4, No.5, p.241-245
Shin-ichi Sekizawa , Yukiko Hoshino , Aiko Takasu
Released: October 18, 2017
Abstract Full Text PDF[306K]
Original Article
CYP3A4 induction mechanism of polycyclic aromatic hydrocarbons differs from that of rifampicin in PXR binding element Vol.4, No.5, p.229-239
Yusuke Aratsu , Reo Odagiri , Rie Shoji , Kouki Watanabe , Takeshi Kumagai , Sawako Shindo , Takamitsu Sasaki , Kiyoshi Nagata
Released: October 05, 2017
Abstract Full Text PDF[909K]
Original Article
A 4-week oral gavage toxicity study of L-citrulline in rats Vol.4, No.5, p.219-227
Masahiko Morita , Tsuyoshi Yamaguchi , Koji Morishita , Ayako Kamimura
Released: September 27, 2017
Abstract Full Text PDF[680K]
Original Article
Toxicity in repeated 28-day oral administration of N-phenyl-1-naphthylamine in rats Vol.4, No.5, p.207-218
Shihori Tanabe , Masahito Ohara , Masaya Ito , Atsushi Noda , Katsumi Kobayashi , Mariko Matsumoto , Akihiko Hirose
Released: September 13, 2017
Abstract Full Text PDF[211K]
Letter
Organophosphorus insecticide dichlorvos inhibits fatty acid amide hydrolase in the male reproductive organs of rats Vol.4, No.5, p.201-205
Naoko Oya , Yuki Ito , Michihiro Kamijima
Released: August 30, 2017
Abstract Full Text PDF[1M]
Toxicomics Report
Expression levels of 39 Cyp mRNAs in the mouse brain and neuroblastoma cell lines, C-1300N18 and NB2a – strong expression of Cyp1b1 Vol.4, No.5, p.195-200
Satoshi Yamaori , Rongrong Jiang , Chikako Maeda , Risa Ogawa , Hiroyuki Okazaki , Hironori Aramaki , Kazuhito Watanabe
Released: August 24, 2017
Abstract Full Text PDF[184K]
Letter
A new insight into proliferative action of bisphenol A at low-dose Vol.4, No.4, p.191-193
Masami Ishido , Rumiko Usu
Released: July 22, 2017
Abstract Full Text PDF[219K]
Letter
HSP70-Ran-RCC1 transport system during cadmium-induced apoptosis in porcine kidney LLC-PK1 cells Vol.4, No.4, p.187-189
Masami Ishido , Rumiko Usu
Released: July 22, 2017
Abstract Full Text PDF[482K]
Original Article
Disposition of perfluorododecanoic acid in male rats after oral administration Vol.4, No.4, p.179-186
Kohei Kawabata , Suzuka Tamaki , Eri Kokubo , Yukari Kobayashi , Tomoya Shinohara , Ayako Sakai , Hiroshi Kawai , Atsushi Mitsumoto , Yoichi Kawashima , Naomi Kudo
Released: July 20, 2017
Abstract Full Text PDF[394K]
Letter
Cytometric analysis on cytotoxicity of 4,4′-methylenediphenyl diisocyanate, a chemical allergen, in rat thymocytes Vol.4, No.4, p.173-178
Keisuke Oyama , Norikazu Miyoshi , Yasuo Oyama
Released: July 08, 2017
Abstract Full Text PDF[1M]
Letter
Original Article
Original Article
Original Article
No carcinogenicity of poly-trans-[(2-carboxyethyl) germasesquioxane] (Ge-132): 26-week feeding study using rasH2 mice Vol.4, No.3, p.137-150
Yuko Doi , Norio Imai , Mayuko Suguro , Takamasa Numano , Fumio Furukawa
Released: June 28, 2017
Abstract Full Text PDF[883K]
Letter
Original Article
Utility of murine dendritic cell line DC2.4 for in vitro assay of skin-sensitization potential Vol.4, No.3, p.121-126
Erina Shiraishi , Akiko Ido , Youhei Hiromori , Kento Tanaka , Tomoki Kimura , Hisamitsu Nagase , Tsuyoshi Nakanishi
Released: June 09, 2017
Abstract Full Text PDF[766K]
Letter
Permeability of skin to silver nanoparticles after epidermal skin barrier disruption in rats Vol.4, No.3, p.109-119
Makiko Kuwagata , Fumiaki Kumagai , Yoshiaki Saito , Kazuma Higashisaka , Yasuo Yoshioka , Yasuo Tsutsumi
Released: June 09, 2017
Abstract Full Text PDF[2M]
Letter
A study for finding new phototoxicity descriptors related to potential energy Vol.4, No.3, p.105-107
Yu Haranosono , Shingo Nemoto , Masaaki Kurata , Hideyuki Sakaki
Released: June 02, 2017
Abstract Full Text PDF[359K]
Letter
Phytocannabinoids, Δ9-tetrahydrocannabinol and cannabidiol, as human calpain-1 (CAPN1) activators Vol.4, No.2, p.101-103
Shuso Takeda , Kazuhito Watanabe , Hironori Aramaki
Released: May 13, 2017
Abstract Full Text PDF[248K]
Original Article
Repeated-dose ocular instillation toxicity study: a survey of its study design on the basis of common technical documents in Japan Vol.4, No.2, p.95-99
Masaaki Kurata , Yoshinori Yamagiwa , Yu Haranosono , Hideyuki Sakaki
Released: May 13, 2017
Abstract Full Text PDF[1M]
Original Article
Quantitative morphometric analysis of vimentin filaments in Sertoli cells of rats after in utero DBP exposure Vol.4, No.2, p.85-93
Eisuke Kume , Yuya Okayama , Mituru Sugiyama , Hiroyuki Takahashi , Tomoko Muto , Michael F. Wempe , Hiroshi Ikegami , Shin Wakui
Released: May 13, 2017
Abstract Full Text PDF[15M]
Toxicomics Report
Urinary proteome profile of renal papillary necrosis in experimental model rats Vol.4, No.2, p.77-83
Daisuke Sasaki , Masashi Hiramoto , Masatoshi Yuri , Kenjiro Tsubota , Hikaru Mitori , Akira Moriguchi , Akira Unami , Gi-Wook Hwang , Akira Naganuma
Released: April 14, 2017
Abstract Full Text PDF[410K]
Original Article
Safety assessment of a soluble dietary fiber, isomaltodextrin, enzymatically produced from starch Vol.4, No.2, p.57-75
Tsuyoshi Sadakiyo , Shin-ichiro Inoue , Yuki Ishida , Hikaru Watanabe , Hitoshi Mitsuzumi , Shimpei Ushio
Released: March 25, 2017
Abstract Full Text PDF[344K]
Original Article
Oral acute and chronic toxicity studies of β, β-dimethylacrylalkannin in mice and rats Vol.4, No.2, p.45-56
Piao-Piao Zhang , Xiao-Dan Yan , Xiao-Yu Fan , Ya-Hao Ling , Chao Li , Lin Lin , Dan Qin , Tian-Tian Liu , Ye Li , Hui Li , Qianqian Zhang , Wen-Bo Mu , Ai-Ping Wang , Hong-Tao Jin , Jin-Feng Wei
Released: March 17, 2017
Abstract Full Text PDF[4M]
Letter
Small interfering RNA-mediated knockdown of the transcription factor TCF3 enhances sensitivity to methylmercury in mouse neural stem cells Vol.4, No.2, p.41-43
Tsutomu Takahashi , Yanjiao Wang , Takashi Toyama , Min-Seok Kim , Shusuke Kuge , Gi-Wook Hwang , Akira Naganuma
Released: March 07, 2017
Abstract Full Text PDF[874K]
Toxicomics Report
Identification of transcription factors activated by methylmercury in mouse brain Vol.4, No.1, p.37-39
Min-Soek Kim , Tsutomu Takahashi , Jin-Yong Lee , Nobuhiko Miura , Masato Asanuma , Gi-Wook Hwang , Akira Naganuma
Released: February 24, 2017
Abstract Full Text PDF[329K]
Toxicomics Report
Proteomic analysis of valproic acid-induced embryotoxicity in cultured post-implantation rat embryos Vol.4, No.1, p.31-35
Makoto Usami , Mina Takamatsu , Shugo Kazama , Katsuyoshi Mitsunaga , Atsuko Miyajima , Tomohiko Irie , Osamu Doi , Tatsuya Takizawa , Teruko Nagi , Momoko Sunouchi
Released: February 24, 2017
Abstract Full Text PDF[1M]
Original Article
Application of a portable gas chromatograph for quantitative measurement of canine oral malodor Vol.4, No.1, p.23-29
Naoki Iwashita , Kazutoshi Sugita , Mitsuyuki Shirai , Sayaka Murata , Shiho Yanagisawa , Sumio Goto , Yukihiko Takagi , Fumitoshi Asai
Released: February 24, 2017
Abstract Full Text PDF[521K]
Original Article
Normal ovarian aging, but modified T-cell differentiation, in female mice following neonatal exposure to bisphenol A Vol.4, No.1, p.15-21
Ryo Ohta , Hideo Ohmukai , Tsukasa Negura , Yoshiyuki Tazura , Omoko Shindo
Released: February 17, 2017
Abstract Full Text PDF[1M]
Letter
Effects of oral administration of gelatin capsules on plasma insulin and glucagon levels in dogs Vol.4, No.1, p.9-14
Hideaki Yokoyama , Taku Masuyama , Tomio Ishida , Yusuke Suzuki , Toshiyuki Shoda , Hideyuki Kuno , Shoichiro Sugai
Released: February 08, 2017
Abstract Full Text PDF[377K]
Original Article
Simultaneous depletion of WRNIP1 and RAD52 restores resistance to oxidative stress Vol.4, No.1, p.1-7
Akari Yoshimura , Haruna Yabe , Miho Akatani , Masayuki Seki , Takemi Enomoto
Released: January 27, 2017
Abstract Full Text PDF[1M]

2016 - Vol. 3

Original Article
Streptozotocin-induced diabetic state triggers glucose-dependent insulinotropic polypeptide (GIP) expression in the rat liver Vol.3, No.6, p.291-296
Yuka Kohda , Chiaki Minamigawa , Mikako Matsuo , Hitoshi Matsumura
Released: December 24, 2016
Abstract Full Text PDF[694K]
Original Article
Sensitivity of MT-III null mice upon chronic exposure to cadmium Vol.3, No.6, p.285-289
Jin-Yong Lee , Maki Tokumoto , Yasuyuki Fujiwara , Gi-Wook Hwang , Moo-Yeol Lee , Masahiko Satoh
Released: December 21, 2016
Abstract Full Text PDF[892K]
Letter
Cadmium-induced protein ubiquitination in UBA80 knockdown HK-2 cells Vol.3, No.6, p.281-284
Jin-Yong Lee , Maki Tokumoto , Gi-Wook Hwang , Masahiko Satoh
Released: November 26, 2016
Abstract Full Text PDF[634K]
Letter
DNA microarray analysis of fetal liver of C57BL/6J mice exposed to cadmium during gestation Vol.3, No.6, p.257-280
Hisaka Kurita , Hisamitsu Nagase , Maki Tokumoto , Jin-Yong Lee , Masahiko Satoh
Released: November 26, 2016
Abstract Full Text PDF[232K]
Original Article
Validation of retrospective evaluation method for false genotoxic chemicals with strong cytotoxicity: re-evaluation using in vitro micronucleus test Vol.3, No.6, p.251-256
Yurika Fujita , Yuichi Ito , Osamu Morita , Hiroshi Honda
Released: November 25, 2016
Abstract Full Text PDF[294K]
Letter
Safety assessment of probiotic bacteria, Bacillus coagulans strain SANK70258, in rats Vol.3, No.6, p.243-250
Yui Akagawa , Yasuyuki Ohnishi , Masatoshi Takaya , Yuko Watanabe
Released: October 19, 2016
Abstract Full Text PDF[283K]
Letter
Combined effect of circadian dysfunction and cadmium on immune suppression Vol.3, No.5, p.237-242
Katsumi Ohtani , Atsushige Ashimori , Yukie Yanagiba , Hiroki Yoshioka , Tatsuya Hasegawa , Gi-Wook Hwang , Masayuki Ikeda , Nobuhiko Miura
Released: October 04, 2016
Abstract Full Text PDF[344K]
Letter
Hepatoprotective effect of kampo formula “Juzen-taiho-to” on bromobenzene-induced toxicity in mice Vol.3, No.5, p.233-236
Hiroki Yoshioka , Shiori Fukaya , Nobuhiko Miura , Akito Nagatsu , Tsunemasa Nonogaki
Released: September 10, 2016
Abstract Full Text PDF[278K]
Minireview
Ocular instillation toxicity study: current status and points to consider on study design and evaluation Vol.3, No.5, p.217-232
Masaaki Kurata , Ikuyo Atsumi , Yoshinori Yamagiwa , Hideyuki Sakaki
Released: August 18, 2016
Abstract Full Text PDF[285K]
Original Article
In vitro and in vivo toxicological assessments of Antrodia cinnamomea health food product (Leader Antrodia cinnamomea Capsule) Vol.3, No.5, p.205-216
Yu-Hsing Lin , K.J. Senthil Kumar , M. Gokila Vani , Jiunn-Wang Liao , Chin-Chung Lin , Jong-Tar Kuo , Sheng-Yang Wang
Released: August 02, 2016
Abstract Full Text PDF[234K]
Original Article
Acute toxicity of phorate oxon by oral gavage in the Sprague-Dawley rat Vol.3, No.5, p.195-204
Thomas H. Snider , Kevin G. McGarry , Michael C. Babin , David A. Jett , Gennady E. Platoff Jr. , David T. Yeung
Released: July 22, 2016
Abstract Full Text PDF[4M]
Original Article
Neurobehavioral toxicity related to the exposure of weaning mice to low-level mercury vapor and methylmercury and influence of aging Vol.3, No.4, p.185-193
Minoru Yoshida , Jin-Yong Lee , Hana Shimizu-Furusawa , Masahiko Satoh , Chiho Watanabe
Released: June 17, 2016
Abstract Full Text PDF[1M]
Original Article
Estimation of occupational exposure to drugs during tablet crushing Vol.3, No.4, p.177-183
Shizuko Maeda , Eiko Takahashi , Yoshitaka Tayama , Shigeyuki Kitamura , Toyohisa Tsukamoto , Katsushi Miyake , Kazumi Sugihara
Released: June 15, 2016
Abstract Full Text PDF[873K]
Original Article
The in vivo Pig-a gene mutation assay is applied to study the genotoxicity of procarbazine hydrochloride in Sprague-Dawley rats Vol.3, No.4, p.167-175
Jiang Pu , Yuanyuan Deng , Xiaoyan Tan , Gaofeng Chen , Cong Zhu , Naisong Qi , Hairuo Wen , Jun Guo , Xin Wang , Yuwen Qiu , Jinqiang Liang , Xinlu Fu , Yanping Hu , Jie Song , Xingchao Geng , Chao Wang , Lin Zhang , Zhiying Huang , Bo Li , Xue Wang
Released: May 31, 2016
Abstract Full Text PDF[2M]
Original Article
A high-throughput Bhas 42 cell transformation assay for the determination of the carcinogenicity of three herbal extracts Vol.3, No.4, p.157-166
Jiang Pu , Ying Wang , Naisong Qi , Wenwan Du , Xiaoyan Tan , Gaofeng Chen , Hairuo Wen , Xin Wang , Yanping Hu , Jie Song , Yuwen Qiu , Jinqiang Liang , Xinlu Fu , Zhiying Huang , Xue Wang
Released: May 31, 2016
Abstract Full Text PDF[2M]
Original Article
Original Article
Peroxisome proliferator activated receptor-mediated genotoxicity of perfluoroalkyl acids using human lymphoblastoid cells Vol.3, No.4, p.143-150
Maki Nakamura , Tomomi Takahashi , Takuya Izumi , Masanori Miura , Satomi Kawaguchi , Ayumi Yamamoto , Shuji Tsuda , Takanori Nakamura , Shuhei Tanaka , Naoto Shimizu , Yu F. Sasaki
Released: May 20, 2016
Abstract Full Text PDF[1M]
Original Article
GCN5-deficiency remarkably enhances the sensitivity of B cells in response to 4-nitroquinoline 1-oxide Vol.3, No.3, p.137-142
Hidehiko Kikuchi , Futoshi Kuribayashi , Hitomi Mimuro , Shinobu Imajoh-Ohmi
Released: May 17, 2016
Abstract Full Text PDF[451K]
Letter
Acute hepatotoxicity induced by quetiapine fumarate in larval zebrafish Vol.3, No.3, p.127-135
Jinfeng Liang , Wangdong Jin , Haibin Wei , Hongwen Li , Fei Jia , Jing Qian , Hongcui Liu , Yanfeng Huang , Chunqi Li , Li Zhou , Thomas Efferth
Released: May 11, 2016
Abstract Full Text PDF[2M]
Letter
Methyl cinnamate increases cell vulnerability to oxidative stress induced by hydrogen peroxide in rat thymocytes Vol.3, No.3, p.121-125
Hiromitsu Tsuzuki , Shota Inoue , Daiki Kobayashi , Gantulga Uuganbaatar , Kaori Kanemaru , Kumio Yokoigawa , Yasuo Oyama
Released: May 11, 2016
Abstract Full Text PDF[1M]
Letter
Possible involvement of FosB in (–)-xanthatin-mediated anti-proliferative effects in human cancer MDA-MB-231 cells Vol.3, No.3, p.115-119
Shuso Takeda , Shunsuke Okajima , Momoko Noguchi , Hiroko Miyoshi , Kuniyoshi Koyachi , Kenji Matsumoto , Mitsuru Shindo , Hironori Aramaki
Released: May 11, 2016
Abstract Full Text PDF[287K]
Letter
Cytotoxicity of zinc, copper and rhodium complexes with 1,10-phenanthroline or 2,9-dimethyl-1,10-phenanthroline in cultured vascular endothelial cells Vol.3, No.3, p.109-113
Takato Hara , Hiroka Matsuzaki , Takehiro Nakamura , Eiko Yoshida , Takanori Ohkubo , Hiroki Maruyama , Chika Yamamoto , Shinichi Saito , Toshiyuki Kaji
Released: May 11, 2016
Abstract Full Text PDF[3M]
Original Article
Major histocompatibility complex expression in a rotenone model of Parkinson’s disease in rats Vol.3, No.3, p.101-108
Masami Ishido , Eiko Shimaya
Released: April 20, 2016
Abstract Full Text PDF[2M]
Letter
Requirements for human iPS cell-derived hepatocytes as an alternative to primary human hepatocytes for assessing absorption, distribution, metabolism, excretion and toxicity of pharmaceuticals Vol.3, No.3, p.89-99
Tetsuro Araki , Norihiko Iwazaki , Naoki Ishiguro , Atsushi Sakamoto , Keisuke Nagata , Masato Ohbuchi , Hiroyuki Moriguchi , Makiko Motoi , Raku Shinkyo , Toshiki Homma , Sakae Sakamoto , Yumiko Iwase , Ryota Ise , Yasuharu Nakanishi , Masahiro Uto , Tomoaki Inoue
Released: April 05, 2016
Abstract Full Text PDF[1M]
Original Article
Comparative study of the zebrafish embryonic toxicity test and mouse embryonic stem cell test to screen developmental toxicity of human pharmaceutical drugs Vol.3, No.2, p.79-87
Atsuto Inoue , Yuhei Nishimura , Norihito Matsumoto , Noriko Umemoto , Yasuhito Shimada , Toru Maruyama , Kana Kayasuga , Motohiko Morihara , Jun Katagi , Tsutomu Shiroya , Yasushi Hirota , Soonih Kim , Toshio Tanaka
Released: March 26, 2016
Abstract Full Text PDF[2M]
Toxicomics Report
Overexpression of palmitoyl transferase HIP14 confers resistance to methylmercury in SH-SY5Y human neuroblastoma cells Vol.3, No.2, p.75-77
Yousuke Ogiwara , Nobuhiko Miura , Shusuke Kuge , Akira Naganuma , Gi-Wook Hwang
Released: March 26, 2016
Abstract Full Text PDF[196K]
Original Article
Prenatal exposure to rutile-type alumina-coated titanium dioxide nanoparticles impairs mouse spermatogenesis Vol.3, No.2, p.67-74
Miyoko Kubo-Irie , Yusuke Shinkai , Shotaro Matsuzawa , Hiroki Uchida , Kenichiro Suzuki , Rikio Niki , Shigeru Oshio , Ken Takeda
Released: March 17, 2016
Abstract Full Text PDF[4M]
Toxicomics Report
Transcription factor activation in rat primary astrocytes exposed to methylmercury Vol.3, No.2, p.63-65
Takuya Takemoto , Yasuhiro Ishihara , Mayumi Tsuji , Toshihiro Kawamoto , Takeshi Yamazaki
Released: March 04, 2016
Abstract Full Text PDF[169K]
Letter
HU-210, a synthetic analog of Δ9-THC, is not a modifier of estrogen signaling in MCF-7 human breast cancer cells Vol.3, No.2, p.55-61
Hiroyuki Okazaki , Shuso Takeda , Hiroyuki Ishii , Saki Matsuo , Erika Furuta , Kazuhito Watanabe , Hironori Aramaki
Released: March 03, 2016
Abstract Full Text PDF[389K]
Letter
Differing responses of human stem cell-derived cardiomyocytes to arrhythmogenic drugs, determined using impedance measurements Vol.3, No.2, p.47-53
Arisa Higa , Hirotaka Hoshi , Motoki Takagi
Released: February 26, 2016
Abstract Full Text PDF[2M]
Original Article
Toxicogenomic prediction with graph-based structured regularization on transcription factor network Vol.3, No.2, p.39-46
Keisuke Nagata , Yoshinobu Kawahara , Takashi Washio , Akira Unami
Released: February 26, 2016
Abstract Full Text PDF[888K]
Letter
Fipronil, an insecticide, acts as an anti-estrogen via the concomitant down-regulation of ERα and PES1 Vol.3, No.1, p.33-37
Hiroyuki Okazaki , Eriko Kohro-Ikeda , Shuso Takeda , Hiroyuki Ishii , Erika Furuta , Saki Matsuo , Masaya Matsumoto , Masufumi Takiguchi , Hironori Aramaki
Released: February 23, 2016
Abstract Full Text PDF[295K]
Letter
Original Article
A study on the influence of acotiamide hydrochloride hydrate on sex hormones, using a uterotrophic bioassay in rat Vol.3, No.1, p.19-25
Hiroyuki Kuroda , Takashi Yamaguchi , Toshiko Kinomoto , Shuji Ogawa , Hitoshi Naraoka , Kazuhiko Takamatsu , Yuji Oishi
Released: January 26, 2016
Abstract Full Text PDF[1M]
Original Article
Hepatitis C virus core can induce lipid droplet formation in a yeast model system Vol.3, No.1, p.13-18
Shingo Iwasa , Naoko Satoh , Hayato Irokawa , Junichi Kikuchi , Jun Okawa , Masataka Nomoto , Gi-Wook Hwang , Akira Naganuma , Shusuke Kuge
Released: January 13, 2016
Abstract Full Text PDF[902K]
Letter
Single dose oral toxicity study of Picrorhiza kurroa rhizome extract in Wistar rats Vol.3, No.1, p.9-12
Acharya Bal Krishna , Hemanth Kumar Manikyam , Vinay K Sharma , Niti Sharma
Released: January 13, 2016
Abstract Full Text PDF[226K]
Letter
Physiological conditions in iPRECIO® -implanted rats Vol.3, No.1, p.1-8
Masaru Tsuboi , Yoshihide Ueda , Yasufumi Ota , Hiroshi Takehara , Takuya Aoshima , Fukutaro Mizuhashi
Released: January 09, 2016
Abstract Full Text PDF[471K]

2015 - Vol. 2

Toxicomics Report
The enhancement effect of HIST1H4C knockdown on cadmium toxicity in human proximal tubular cells Vol.2, No.6, p.259-262
Jin-Yong Lee , Maki Tokumoto , Masahiko Satoh
Released: December 22, 2015
Abstract Full Text PDF[274K]
Original Article
Developmental changes in associative learning behavior in male rats Vol.2, No.6, p.249-258
Rieko Hojo , Yukie Yanagiba , Megumi Suda , Masao Tsuchiya
Released: December 22, 2015
Abstract Full Text PDF[380K]
Toxicomics Report
Knockdown of Acyl-CoA thioesterase 9 gene expression by siRNA confers resistance to arsenite in HEK293 cells Vol.2, No.6, p.245-247
Tsutomu Takahashi , Min-Seok Kim , Gi-Wook Hwang , Shusuke Kuge , Akira Naganuma
Released: December 21, 2015
Abstract Full Text PDF[295K]
Letter
Methylmercury induces expression of interleukin-1β and interleukin-19 in mice brains Vol.2, No.6, p.239-243
Tsutomu Takahashi , Miyuki Iwai-Shimada , Yukina Syakushi , Min-Seok Kim , Gi-Wook Hwang , Nobuhiko Miura , Akira Naganuma
Released: December 21, 2015
Abstract Full Text PDF[471K]
Letter
(–)-Xanthatin-mediated marked up-regulation of RhoB, a sensor for damaged DNA Vol.2, No.6, p.233-238
Shuso Takeda , Shunsuke Okajima , Hiroko Miyoshi , Kuniyoshi Koyachi , Kenji Matsumoto , Mitsuru Shindo , Hironori Aramaki
Released: December 12, 2015
Abstract Full Text PDF[396K]
Letter
Citrulline enhances methylmercury toxicity in HEK293 and C17.2 cells Vol.2, No.6, p.229-231
Takashi Toyama , Gi-Wook Hwang , Akira Naganuma
Released: December 11, 2015
Abstract Full Text PDF[530K]
Toxicomics Report
Metabolomic analysis of low molecular weight substances released into medium from HEK293 cells treated with methylmercury Vol.2, No.5, p.227-228
Takashi Toyama , Gi-Wook Hwang , Akira Naganuma
Released: December 09, 2015
Abstract Full Text PDF[158K]
Original Article
Methylmercury induces release of a cytotoxic factor from HEK293 cells into medium Vol.2, No.5, p.223-226
Takashi Toyama , Souichi Murakami , Shusuke Kuge , Gi-Wook Hwang , Akira Naganuma
Released: December 02, 2015
Abstract Full Text PDF[988K]
Letter
Cytotoxic actions of N-(2,4,6-trichlorophenyl)maleimide (IT-354), an antifouling agent, in rat thymic lymphocytes Vol.2, No.5, p.217-222
Eri Fukunaga , Shohei Saito , Yuya Kurumi , Yurie Ohiwa , Eri Kurozumi , Yasuo Oyama
Released: November 26, 2015
Abstract Full Text PDF[1M]
Original Article
Zn2+-dependent increase in cells with phosphatidylserine-exposed membranes after treatment with submicromolar concentrations of 2-n-octyl-4-isothiazolin-3-one in rat thymocytes Vol.2, No.5, p.209-216
Eri Fukunaga , Sari Honda , Yuji Hashimoto , Yasuaki Tamura , Shiro Ishida , Yasuo Oyama
Released: November 16, 2015
Abstract Full Text PDF[1M]
Original Article
Bioconcentration of perfluorinated compounds in wild medaka is related to octanol/water partition coefficient Vol.2, No.5, p.201-208
Katsumi Iwabuchi , Norimasa Senzaki , Shuji Tsuda , Haruna Watanabe , Ikumi Tamura , Hitomi Takanobu , Norihisa Tatarazako
Released: October 27, 2015
Abstract Full Text PDF[673K]
Original Article
A repeated dose 28-day oral toxicity study of β-bromostyrene in rats Vol.2, No.4, p.191-200
Atsushi Ono , Katsumi Kobayashi , Hideki Serizawa , Tomoko Kawamura , Hina Kato , Mariko Matsumoto , Mika Takahashi , Mutsuko Hirata-Koizumi , Yuko Matsushima , Akihiko Hirose
Released: September 29, 2015
Abstract Full Text PDF[202K]
Original Article
Repeated dose and reproductive/developmental toxicity of long-chain perfluoroalkyl carboxylic acids in rats: perfluorohexadecanoic acid and perfluorotetradecanoic acid Vol.2, No.4, p.177-190
Mutsuko Hirata-Koizumi , Sakiko Fujii , Kato Hina , Mariko Matsumoto , Mika Takahashi , Atsushi Ono , Akihiko Hirose
Released: September 28, 2015
Abstract Full Text PDF[369K]
Letter
Health survey of workers in a 2,4,6-trinitrotoluene explosives factory in Fuxin, China Vol.2, No.4, p.171-175
Yasuhiro Shinkai , Song Li , Tomohiro Kikuchi , Nobuhiro Shimojo , Yoshito Kumagai
Released: September 15, 2015
Abstract Full Text PDF[172K]
Original Article
Toxicogenomic prediction with group sparse regularization based on transcription factor network information Vol.2, No.4, p.161-170
Keisuke Nagata , Yoshinobu Kawahara , Takashi Washio , Akira Unami
Released: September 15, 2015
Abstract Full Text PDF[1M]
Letter
Effects of rofecoxib on lipid oxidation in plasma and aortas of rats Vol.2, No.4, p.155-159
Atsushi Miyajima , Yasuha Amano , Takeyoshi Kamamoto , Masahiro Okamoto , Takashi Hirota
Released: September 07, 2015
Abstract Full Text PDF[243K]
Letter
In vitro comet assay in cultured human corneal epithelial cells Vol.2, No.4, p.147-153
Hideyuki Sakaki , Masaki Kakehi , Kazuyo Sadamoto , Shingo Nemoto , Masaaki Kurata
Released: September 04, 2015
Abstract Full Text PDF[1M]
Original Article
Effects of cisplatin on testicular enzymes and Sertoli cell function in rats Vol.2, No.4, p.137-145
Zhifei Liu , Yingbiao Sun , Li Su , Yifan Sun , Shibo Kong , Xuhong Chang , Fang Guo , Wei Li , Junjie Guo , Jin Li
Released: August 25, 2015
Abstract Full Text PDF[1M]
Original Article
Effects of dietary fish oil on cytochrome P450 3A expression in the liver of SHR/NDmcr-cp (cp/cp) rats, an animal model for metabolic syndrome Vol.2, No.3, p.127-135
Tohru Yamazaki , Takashi Ohki , Hiroki Taguchi , Asami Yamamoto , Mari Okazaki , Takeshi Sakamoto , Atsushi Mitsumoto , Yoichi Kawashima , Naomi Kudo
Released: August 05, 2015
Abstract Full Text PDF[347K]
Original Article
The concern for uterine carcinogenesis in safety assessments for a new pharmaceutical Vol.2, No.3, p.117-126
Hiroyuki Kuroda , Takashi Yamaguchi , Toshiko Kinomoto , Shuji Ogawa , Atsushi Shiga , Hitoshi Naraoka , Kazuhiko Takamatsu , Yuji Oishi
Released: July 30, 2015
Abstract Full Text PDF[2M]
Letter
Evaluation of laser irradiance on photodynamic therapy using talaporfin sodium-induced glioblastoma T98G cell death Vol.2, No.3, p.111-116
Yuichi Miki , Jiro Akimoto , Aya Sato , Yasuyuki Fujiwara
Released: June 26, 2015
Abstract Full Text PDF[2M]
Letter
Positive and negative ions by air purifier have no effects on reproductive function or postnatal growth and development in rats Vol.2, No.3, p.101-110
Dai Yamamoto , Yumi Wako , Shino Kumabe , Kiyoshi Wako , Yukari Sato , Mayumi Fujishiro , Yoshimasa Yasuda , Ikuo Matsuura , Yasuyuki Ohnishi
Released: June 23, 2015
Abstract Full Text PDF[181K]
Original Article
Metabolism of trimethylselenonium ion in selenium accumulator, Allium sativum Vol.2, No.3, p.95-99
Yasumitsu Ogra , Yurie Ogihara , Yasumi Anan
Released: June 16, 2015
Abstract Full Text PDF[379K]
Toxicomics Report
DNA microarray analysis of genes in highly metastatic 4T1E/M3 murine breast cancer cells following exposure to cannabidiolic acid Vol.2, No.2, p.89-94
Shuso Takeda , Hiroyuki Okazaki , Eriko Kohro-Ikeda , Kazutaka Yoshida , Miki Tokuyasu , Yukimi Takemoto , Ramu Mizunoe , Sawa Tanaka , Tomoko Okada , Hironori Aramaki
Released: June 01, 2015
Abstract Full Text PDF[524K]
Original Article
Measurement of oral bacterial counts in dogs by dielectrophoretic impedance Vol.2, No.2, p.83-87
Soraaki Takahashi , Motoi Kuratani , Maho Tanaka , Tetsuro Ito , Nobuyuki Kanemaki , Mitsuyuki Shirai , Ryota Nomura , Kazuhiko Nakano , Fumitoshi Asai
Released: May 27, 2015
Abstract Full Text PDF[221K]
Letter
Motor activities of newborns prenatally exposed to low-dose bisphenol A in diverse mouse strains Vol.2, No.2, p.79-82
Nao Kagawa , Munekazu Komada , Tetsuji Nagao
Released: May 27, 2015
Abstract Full Text PDF[238K]
Original Article
Effect of prenatal methylmercury exposure on neurobehavioral development in male mice: comparison between methylmercury in fish and methylmercury chloride added to diets Vol.2, No.2, p.67-78
Miyuki Iwai-Shimada , Michiaki Yamashita , Naoyuki Kurokawa , Kunihiko Nakai , Mitsuharu Ishida , Akira Naganuma , Hiroshi Satoh
Released: April 03, 2015
Abstract Full Text PDF[481K]
Letter
Comparative cytotoxicity of triphenylstibane and fluorine-substituted triarylpnictogens in cultured vascular endothelial cells Vol.2, No.2, p.61-66
Masaki Murakami , Tomoya Fujie , Mio Matsumura , Eiko Yoshida , Chika Yamamoto , Yasuyuki Fujiwara , Shuji Yasuike , Toshiyuki Kaji
Released: March 28, 2015
Abstract Full Text PDF[1M]
Original Article
Metabolic fate of excessive glucose in fibroblast cells in a diabetic setting Vol.2, No.2, p.55-60
Yuka Kohda , Kazuma Iwatate , Takao Tanaka , Hitoshi Matsumura
Released: February 20, 2015
Abstract Full Text PDF[327K]
Letter
Comparison of cytotoxicity among pectenotoxin-2 and other oxidized pectenotoxins in a rat myoblast cell line (L6) and a human rhabdomyosarcoma cell line (RD) Vol.2, No.1, p.49-54
Ryoji Matsushima , Saori Kikutsugi , Ryuichi Watanabe , Hajime Uchida , Takeshi Yasumoto , Hiroshi Nagai , Masaki Kaneniwa , Toshiyuki Suzuki
Released: February 03, 2015
Abstract Full Text PDF[1M]
Original Article
Utility of human hepatocyte spheroids for evaluation of hepatotoxicity Vol.2, No.1, p.41-48
Takuo Ogihara , Hisakazu Iwai , Yukiko Inoue , Jun Katagi , Norihito Matsumoto , Makiko Motoi-Ohtsuji , Motoharu Kakiki , Shinya Kaneda , Takuya Nagao , Kumiko Kusumoto , Emiko Ozeki , Tomoko Jomura , Sho Tanaka , Tadayoshi Ueda , Kunihiro Ohta , Takako Ohkura , Hiroshi Arakawa , Daichi Nagai
Released: January 21, 2015
Abstract Full Text PDF[489K]
Letter
Effects of prenatal exposure to low doses of diethylstilbestrol on motor activity in newborn mice Vol.2, No.1, p.37-39
Kaho Ozaki , Nao Kagawa , Munekazu Komada , Tetsuji Nagao
Released: January 16, 2015
Abstract Full Text PDF[200K]
Original Article
Impact of different blood sampling techniques on plasma biomarkers for skeletal myopathy in conscious rats Vol.2, No.1, p.25-36
Kyoko Miwa , Satoshi Tamai , Yasuhiro Kinpara , Satomi Komatsu , Mayumi Goto , Takuma Iguchi , Takami Suzuki , Wataru Takasaki , Kazuhiko Mori
Released: January 16, 2015
Abstract Full Text PDF[955K]
Letter
Silica nanoparticle-induced toxicity in mouse lung and liver imaged by electron microscopy Vol.2, No.1, p.19-23
Katsuhiro Isoda , Masuo Kondoh , Yasuo Yoshioka , Yasuo Tsutsumi , Takayoshi Imazawa , Tetsuji Nishimura , Isao Ishida , Kiyohito Yagi
Released: January 16, 2015
Abstract Full Text PDF[3M]
Original Article
Effects of sub-chronic exposure to deltamethrin on shuttle-box avoidance and contents of amino acid neurotransmitters in hippocampus of mice Vol.2, No.1, p.9-17
Cao Pei , Ma Ning , Gao Peng , Feng Yong-quan , Wang Xiao-dan , Xu Hai-bin
Released: January 13, 2015
Abstract Full Text PDF[1M]
Original Article
Effect of nanoparticles injected into larvae on spermatogenesis in the pupal testis of the sweet potato hornworm, Agrius convolvuli (L.) Vol.2, No.1, p.1-8
Miyoko Kubo-Irie , Masami Shimoda , Azumi Sato , Kyhota Shida , Terumi Yamaguchi , Hideo Mohri , Ken Takeda , Masaru Irie
Released: January 13, 2015
Abstract Full Text PDF[3M]

2014 - Vol. 1

Letter
Estimation of endoplasmic reticulum stress-inducing ability of nobiletin, a citrus polymethoxyflavonoid, in SK-N-SH human neuroblastoma cells Vol.1, No.4, p.169-172
Ayaka Ikeda , Shingo Miyata , Akihito Yokosuka , Yoshihiro Mimaki , Yasushi Ohizumi , Masakuni Degawa , Kiyomitsu Nemoto
Released: December 25, 2014
Abstract Full Text PDF[363K]
Toxicomics Report
The involvement of GPRC5B in cadmium toxicity in HK-2 cells Vol.1, No.4, p.165-167
Jin-Yong Lee , Maki Tokumoto , Yasuyuki Fujiwara , Moo-Yeol Lee , Masahiko Satoh
Released: December 25, 2014
Abstract Full Text PDF[754K]
Toxicomics Report
CDC23 knockdown reinforces methylmercury sensitivity in HEK293 cells Vol.1, No.4, p.161-164
Ke Du , Tsutomu Takahashi , Miyuki Iwai-Shimada , Nobuhiko Miura , Akira Naganuma , Gi-Wook Hwang
Released: December 24, 2014
Abstract Full Text PDF[1M]
Original Article
Safety evaluation of mutagenecity, acute and subacute toxicity study of Chlorella vulgaris CK-22 in rats Vol.1, No.4, p.151-159
Sayaka Himuro , Sugi Ueno , Naoto Noguchi , Takuya Uchikawa , Koji Watanabe
Released: December 22, 2014
Abstract Full Text PDF[333K]
Original Article
Apoptotic activities of the extract from Moringa oleifera leaves on human HCT116 colon cancer cells Vol.1, No.4, p.143-149
Jintana Tragulpakseerojn , Ryuzaburo Yuki , Takuya Honda , Mariko Morii , Auayporn Apirakaramwong , Noritaka Yamaguchi , Perayot Pamonsinlapatham , Naoto Yamaguchi
Released: December 16, 2014
Abstract Full Text PDF[664K]
Letter
Effects of a repeated low dose of LiCl injection under conditioned taste/flavor aversion using xylene Vol.1, No.4, p.135-142
Rieko Hojo , Mitsutoshi Takaya , Yukie Yanagiba , Akinori Yasuda , Masao Tsuchiya , Yasutaka Ogawa
Released: December 08, 2014
Abstract Full Text PDF[276K]
Toxicomics Report
Effects of cadmium on the gene expression of SLC39A1 coding for ZIP1 protein Vol.1, No.4, p.131-133
Jin-Yong Lee , Maki Tokumoto , Yasuyuki Fujiwara , Moo-Yeol Lee , Masahiko Satoh
Released: December 04, 2014
Abstract Full Text PDF[413K]
Original Article
The paradoxical effect of 1,4-naphthoquinone on the process of cell death induced by hydrogen peroxide in rat thymocytes Vol.1, No.4, p.123-129
Hana Ohtani , Eri Fukunaga , Yasuo Oyama , Shiro Ishida , Norio Akaike
Released: November 21, 2014
Abstract Full Text PDF[937K]
Original Article
Diallyl disulfide administration increases the number of B-lymphocytes in the rat spleen Vol.1, No.4, p.115-121
Yoko Hashizume , Ken Shirato , Kaoru Tachiyashiki , Kazuhiko Imaizumi
Released: November 19, 2014
Abstract Full Text PDF[395K]
Toxicomics Report
Identification of growth-dependent genes involved in paraquat toxicity in Saccharomyces cerevisiae Vol.1, No.3, p.113-114
Tsutomu Takahashi , JunXuan Zhu , Naoya Sonoda , Shusuke Kuge , Gi-Wook Hwang , Akira Naganuma
Released: November 10, 2014
Abstract Full Text PDF[379K]
Toxicomics Report
Overexpression of RPN8, SKP1, MIA40 or MES1 increases resistance to cadmium in Saccharomyces cerevisiae Vol.1, No.3, p.109-111
Tsutomu Takahashi , JunXuan Zhu , Shusuke Kuge , Gi-Wook Hwang , Akira Naganuma
Released: November 10, 2014
Abstract Full Text PDF[301K]
Original Article
Sex-dependent difference in the hepatic and pulmonary toxicological effects in mice administrated 7-chlorinated benz[a]anthracene Vol.1, No.3, p.101-108
Hiroyuki Sakakibara , Takashi Ohura , Yuta Kamiya , Noriko Yamanaka , Nobuaki Shimada , Kayoko Shimoi , Keerthi S. Guruge
Released: November 10, 2014
Abstract Full Text PDF[288K]
Original Article
A screening method for growth-dependent genes involved in the cytotoxicity of chemicals in Saccharomyces cerevisiae Vol.1, No.3, p.95-99
JunXuan Zhu , Tsutomu Takahashi , Shusuke Kuge , Gi-Wook Hwang , Akira Naganuma
Released: November 06, 2014
Abstract Full Text PDF[387K]
Original Article
Residual metals in carbon nanotubes suppress the proliferation of neural stem cells Vol.1, No.3, p.87-94
Yukari Shigemoto-Mogami , Koki Fujimori , Yoshiaki Ikarashi , Akihiko Hirose , Yuko Sekino , Kaoru Sato
Released: November 06, 2014
Abstract Full Text PDF[236K]
Letter
Hazardous effects of titanium dioxide nanoparticles on testicular function in mice Vol.1, No.3, p.81-85
Nobuhiko Miura , Katsumi Ohtani , Tatsuya Hasegawa , Rieko Hojo , Yukie Yanagiba , Tetsuya Suzuki , Megumi Suda , Rui-Sheng Wang
Released: October 28, 2014
Abstract Full Text PDF[218K]
Original Article
Effects of organic and inorganic mercury(II) on gene expression via DNA conformational changes Vol.1, No.2, p.73-79
Koji Ueda , Rena Makino , Takao Tobe , Yoshinori Okamoto , Nakao Kojima
Released: October 23, 2014
Abstract Full Text PDF[593K]
Original Article
A 4-week oral toxicity study of L-alanine in rats with a recovery period of 2 weeks Vol.1, No.2, p.63-72
Mami Aoki , Masahiro Mochizuki , Toshiya Okamura , Kazuhisa Hatayama , Atsushi Nakamura , Koji Morishita
Released: October 23, 2014
Abstract Full Text PDF[206K]
Original Article
A 13-week feeding toxicity study of L-threonine in rats with a recovery period of 5 weeks Vol.1, No.2, p.49-62
Mami Aoki , Shigeru Ishida , Hideki Fukuzumi , Koji Morishita
Released: October 23, 2014
Abstract Full Text PDF[104K]
Original Article
Safety evaluation of morphological changes in corneal endothelial cells induced by K-115 in cynomolgus monkeys Vol.1, No.2, p.39-47
Eiji Wato , Kozo Omichi , Shigeki Yoneyama , Mamoru Tanaka , Masataka Kagawa , Yukinori Amano
Released: October 15, 2014
Abstract Full Text PDF[416K]
Original Article
28-Day dietary toxicity study of L-phenylalanine in rats Vol.1, No.2, p.29-38
Yusuke Shibui , Tadashi Miwa , Terutaka Kodama , Akinori Gonsho
Released: September 27, 2014
Abstract Full Text PDF[100K]
Original Article
Nonclinical safety assessment for the sensitizing potential of K-115 Vol.1, No.1, p.19-27
Kozo Omichi , Eiji Wato , Yoshiki Kaneko , Shigeki Yoneyama , Akitaka Matsuda , Mikio Sasaki , Adrian Bull , David Coleman , Masataka Kagawa , Yukinori Amano
Released: September 04, 2014
Abstract Full Text PDF[109K]
Original Article
Cytotoxic activity and abdominal writhes promoted by snake venom from Philodryas nattereri Steindachner, 1870 Vol.1, No.1, p.15-18
Marinetes Dantas de Aquino Nery , Hermano Damasceno de Aquino , Rayane de Tasso Moreira Ribeiro , Erik de Aquino Nery , Thiala Soares Josino da Silva , Rodrigo Tavares Dantas , Ramon Róseo Paula Pessoa Bezerra de Menezes , Marcus Felipe Bezerra da Costa , Alice Maria Costa Martins , Natacha Teresa Queiroz Alves , Helena Serra Azul Monteiro
Released: September 04, 2014
Abstract Full Text PDF[115K]
Original Article
Edematogenic and myotoxic activities induced by snake venom of Philodryas nattereri from the Northeast of Brazil Vol.1, No.1, p.7-13
Marinetes Dantas de Aquino Nery , Hermano Damasceno de Aquino , Rayane de Tasso Moreira Ribeiro , Erik de Aquino Nery , Dalgimar Beserra de Menezes , Rafael Matos Ximenes , Arislete Dantas de Aquino , Lia Belchior Mendes Bezerra , Natacha Teresa Queiroz Alves , Helena Serra Azul Monteiro
Released: September 04, 2014
Abstract Full Text PDF[1M]
Letter
Investigation of organ-specific assessment factors related to sub-acute and sub-chronic toxicity studies Vol.1, No.1, p.1-6
Jun-ichi Takeshita , Atsuo Kishimoto , Masashi Gamo
Released: August 06, 2014
Abstract Full Text PDF[95K]